{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T17:32:29Z","timestamp":1788888749732,"version":"build-2803163510"},"reference-count":45,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,5,4]],"date-time":"2023-05-04T00:00:00Z","timestamp":1683158400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004829","name":"Department of Science and Technology of Sichuan Province","doi-asserted-by":"publisher","award":["2020YFS0202 and 2023NSFSC0575"],"award-info":[{"award-number":["2020YFS0202 and 2023NSFSC0575"]}],"id":[{"id":"10.13039\/501100004829","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Periodontal Research"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Objective<\/jats:title>\n                    <jats:p>Periodontitis is a chronic inflammatory disease involving soft and hard tissue destruction in the periodontal region. Cannabidiol (CBD) is a natural compound isolated from cannabis, which has the effect of inhibiting inflammation. However, the role of CBD in periodontitis remains unclear. The aim of this study was to investigate the anti\u2010inflammatory effects and osteoprotective actions of CBD in periodontitis and its molecular mechanisms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>After establishing the rat periodontitis model by ligatures, the specimens were processed for morphometric analysis by Micro\u2010CT. The gingival tissues were collected, and the levels of TNF\u2010\u03b1, IL\u20101\u03b2, and TLR4 were measured by enzyme\u2010linked immunosorbent assay. LPS was used to induce the inflammatory response of human periodontal ligament cells (hPDLCs) in vitro. QPCR and western blot were carried out to detect the expression of related inflammatory cytokines and signaling pathways.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Cannabidiol significantly inhibits bone loss in experimental rat periodontitis models. CBD downregulated the pro\u2010inflammatory mediator TNF\u2010\u03b1, related to the decrease of TLR4 protein expression. Overexpression of TNF\u2010\u03b1 and TLR4 caused by LPS in hPDLCs. CBD inactivated the TLR4\/NF\u2010\u03baB signaling pathway by inhibiting TLR\u20104 expression and p65 NF\u2010\u03baB phosphorylation. CBD can be considered as a therapeutic agent for periodontitis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our study demonstrated that CBD attenuates ligature\u2010induced periodontitis in rats and LPS\u2010induced inflammation in hPDLCs by inhibiting TLR4\/NF\u2010\u03baB pathway activation. It indicates that topical CBD application is effective in treating periodontitis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jre.13118","type":"journal-article","created":{"date-parts":[[2023,5,5]],"date-time":"2023-05-05T00:11:11Z","timestamp":1683245471000},"page":"697-707","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Cannabidiol attenuates periodontal inflammation through inhibiting\n                    <scp>TLR4<\/scp>\n                    \/\n                    <scp>NF\u2010\u03baB<\/scp>\n                    pathway"],"prefix":"10.1111","volume":"58","author":[{"given":"Hao","family":"Chen","sequence":"first","affiliation":[{"name":"State Key Laboratory of Oral Diseases, West China Hospital of Stomatology Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaqi","family":"Liu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral Diseases, West China Hospital of Stomatology Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sijing","family":"Yu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral Diseases, West China Hospital of Stomatology Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng","family":"Li","sequence":"additional","affiliation":[{"name":"Yunnan Hempson Bio\u2010Tech Co., Ltd.  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