{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T18:15:09Z","timestamp":1790792109962,"version":"4.1.0"},"reference-count":59,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,6,6]],"date-time":"2023-06-06T00:00:00Z","timestamp":1686009600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Periodontal Research"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>The purpose of this meta\u2010analysis was to look at the differences in oxidative stress (OS) biomarkers between type 2 diabetes mellitus with chronic periodontitis (DMCP) and chronic periodontitis (CP) patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>Oxidative stress has been shown to be a key pathogenic component in DMCP. However, it is unclear whether oxidative stress levels differ in periodontitis patients with or without diabetes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>A systematic search was conducted on PubMed, Cochrane, and Embase databases. Studies of DMCP participants were used as the experimental group and CP participants were used as the control group. Results are expressed as mean effects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of a total of 1989 articles, 19 met the inclusion criteria. We found the levels of catalase (CAT) levels were reduced in the DMCP group compared with the CP group. However, there was no significant difference in the levels of superoxide dismutase (SOD), total antioxidant capacity (TAOC) malondialdehyde (MDA), and glutathione (GSH) between the two groups. And high heterogeneity was observed in some of the studies evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Despite the limitations of this study, our results support the theory that there is an association between T2DM and the levels of OS\u2010related biomarkers, especially CAT, in CP subjects, suggesting that OS plays an important role in the pathogenesis and development of DMCP.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jre.13136","type":"journal-article","created":{"date-parts":[[2023,6,7]],"date-time":"2023-06-07T15:17:52Z","timestamp":1686151072000},"page":"780-790","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Oxidative stress\u2010related biomarkers in chronic periodontitis patients with or without type 2 diabetes: A systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"58","author":[{"given":"Sisi","family":"Chen","sequence":"first","affiliation":[{"name":"College of Stomatology Chongqing Medical University  Chongqing China"},{"name":"Chongqing Key Laboratory of Oral Diseases and Biomedical Sciences  Chongqing China"},{"name":"Chongqing Municipal Key Laboratory of Oral Biomedical Engineering of Higher Education  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang","family":"Gao","sequence":"additional","affiliation":[{"name":"College of Stomatology Chongqing Medical University  Chongqing China"},{"name":"Chongqing Key Laboratory of Oral Diseases and Biomedical Sciences  Chongqing China"},{"name":"Chongqing Municipal Key Laboratory of Oral Biomedical Engineering of Higher Education  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0224-6640","authenticated-orcid":false,"given":"Jinlin","family":"Song","sequence":"additional","affiliation":[{"name":"College of Stomatology Chongqing Medical University  Chongqing China"},{"name":"Chongqing Key Laboratory of Oral Diseases and Biomedical Sciences  Chongqing China"},{"name":"Chongqing Municipal Key Laboratory of Oral Biomedical Engineering of Higher Education  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,6,6]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034516629112"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12162"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1902\/annals.2001.6.1.99"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0528.2002.300304.x"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.16.1.329"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1902\/annals.1998.3.1.51"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(91)90279-7"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.26402\/jpp.2019.6.01"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/JPER.20-0406"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2018.12.143"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.7860\/JCDR\/2016\/17350.7542"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2007.07.009"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/931083"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13112"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.ED000142"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1000100"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1000097"},{"key":"e_1_2_9_19_1","first-page":"1","article-title":"Celiac disease","volume":"104","author":"Rostom A","year":"2004","journal-title":"Evid Rep Technol Assess (Summ)"},{"key":"e_1_2_9_20_1","volume-title":"Statistical Power Analysis for the Behavioral Sciences","author":"Cohen J","year":"1988"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/0197-2456(86)90046-2"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.4103\/0972-124x.138686"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2013.130066"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.5958\/0974-360X.2021.00183.9"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2009.090159"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.4103\/1947-2714.106208"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.4103\/ijnpnd.ijnpnd_66_21"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.4103\/ejd.ejd_244_17"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.4103\/0976-237x.114867"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.22159\/ajpcr.2018.v11i8.25554"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.4103\/jispcd.JISPCD_42_20"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.5051\/jpis.2013.43.2.87"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2013.05.003"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.5005\/jp-journals-10024-2497"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.4103\/0976-237x.118342"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.4103\/jisp.jisp_184_17"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.13005\/bpj\/816"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.15171\/joddd.2018.039"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2011.01764.x"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051x.1993.tb00384.x"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2006.01029.x"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1902\/annals.1999.4.1.1"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.48.1.1"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2004.00509.x"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2006.00923.x"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.22038\/IJBMS.2019.13989"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1111\/jre.12722"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1741-4520.2005.00070.x"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.3892\/ijmm.2016.2549"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/137.3.657"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1007\/s001250050638"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.2006.03276.x"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/917631"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD004714.pub3"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.numecd.2005.05.003"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0009-9120(00)00199-5"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2009.090454"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.20.7.1183"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2006.00892.x"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2006.02.004"}],"container-title":["Journal of Periodontal Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jre.13136","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,17]],"date-time":"2023-08-17T12:03:12Z","timestamp":1692273792000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jre.13136"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6,6]]},"references-count":59,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2023,8]]}},"alternative-id":["10.1111\/jre.13136"],"URL":"https:\/\/doi.org\/10.1111\/jre.13136","archive":["Portico"],"relation":{},"ISSN":["0022-3484","1600-0765"],"issn-type":[{"value":"0022-3484","type":"print"},{"value":"1600-0765","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,6,6]]},"assertion":[{"value":"2023-02-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-04-27","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-06-06","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}