{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T22:36:44Z","timestamp":1788561404964,"version":"build-2803163510"},"reference-count":53,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,8,12]],"date-time":"2023-08-12T00:00:00Z","timestamp":1691798400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Periodontal Research"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Androgenic alopecia (AGA) is men's most common form of hair loss. It is affected by changes in the expression and activity of 5\u03b1R and the metabolism of testosterone and DHT. There is an association between AGA and systemic inflammatory diseases. We hypothesized that there is an association between AGA and periodontal disease, as inflamed gingiva and periodontal fibroblasts have been shown to express more 5\u03b1R. Thus, this study aimed to evaluate the relationship between periodontal disease and AGA and the potential effect of aging on this association.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Out of a cohort of 1088 individuals, 385 white males aged 25\u201365 with similar socioeconomic levels and without systemic disease were included. Periodontitis was defined using NHANES data. AGA was evaluated using the Norwood\u2013Hamilton scale. The relationship between AGA, periodontal disease severity, and age was assessed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There was a correlation between age and baldness (<jats:italic>r<\/jats:italic>\u2009=\u2009.421, <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001). There was a significant correlation between AGA and periodontal disease in younger patients aged 25\u201334 and 35\u201344. (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.042 and <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.036, respectively). There was no significant correlation between AGA and periodontal disease in the 45\u201354 and 55\u201365 age groups (<jats:italic>p<\/jats:italic>\u2009&gt;\u2009.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>There may be a relationship between periodontal disease and AGA in the 25\u201344 age range, suggesting that this association starts at an early age in adulthood.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jre.13175","type":"journal-article","created":{"date-parts":[[2023,8,12]],"date-time":"2023-08-12T08:00:06Z","timestamp":1691827206000},"page":"1105-1111","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Association between androgenetic alopecia and periodontitis"],"prefix":"10.1111","volume":"58","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7333-0524","authenticated-orcid":false,"given":"Yerda \u00d6zkan","family":"Karasu","sequence":"first","affiliation":[{"name":"The 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