{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,15]],"date-time":"2023-11-15T00:10:01Z","timestamp":1700007001220},"reference-count":57,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,9,18]],"date-time":"2023-09-18T00:00:00Z","timestamp":1694995200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Periodontal Research"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Objective<\/jats:title><jats:p>The purpose of this study was to determine if chronic periodontitis (CP) may induce hyperinsulinemia and may have the effect of on pancreatic \u03b2\u2010cell proliferation in a rat model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Twelve male Sprague\u2013Dawley rats were divided into two groups: the CP group and the control group (Con group). The following contents were evaluated: pathological changes in periodontal soft and hard tissues; serum lipopolysaccharide (LPS) level, serum fasting insulin (FINS) level, fasting blood glucose (FBG) level, and homeostasis model assessment (HOMA) \u03b2 (HOMA\u2010\u03b2) index; histopathological examination of islets; immunohistochemistry of insulin and p\u2010Smad2 expression in islets; immunofluorescence of changes in the relative number of \u03b2\u2010cells and the number of Ki67\u2010positive \u03b2\u2010cells. Western blotting was used to analyze p\u2010Smad2\/Smad2 levels. Results were analyzed by two independent samples <jats:italic>t<\/jats:italic> tests.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Increased serum LPS level, FINS level, and HOMA\u2010\u03b2 index were observed in the rats of the CP group; FBG level did not change significantly; histological assessments showed an enlarged islet area, increased insulin content, relatively increased \u03b2\u2010cells, increased Ki67\u2010positive \u03b2\u2010cells, and decreased p\u2010Smad2 expression in islets in the rats of the CP group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our study results link CP\u2010induced hyperinsulinemia with changes in islets, such as islet hyperplasia and compensatory \u03b2\u2010cell proliferation, by using a CP rat 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