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This inflammation has a negative impact on the osteogenic differentiation capacity of periodontal tissue\u2010derived cells. Non\u2010coding RNAs (ncRNAs) are a class of RNA molecules that do not encode proteins but can regulate various physiological processes. In this review, we summarized the critical signaling pathways that ncRNAs modulate in osteogenic differentiation of periodontal tissue\u2010derived cells, such as the Wnt, BMP\/Smad, NF\u2010\u03baB, and PI3\u2010K\/Akt\/mTOR pathways. This comprehensive exploration of ncRNA\u2010mediated modulation offers fresh and promising insights for prospective approaches in the management of periodontitis and the advancement of periodontal regeneration therapies.<\/jats:p>","DOI":"10.1111\/jre.13199","type":"journal-article","created":{"date-parts":[[2023,11,14]],"date-time":"2023-11-14T11:20:21Z","timestamp":1699960821000},"page":"18-31","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["The signaling pathways involved in non\u2010coding <scp>RNA<\/scp> regulation during osteogenic differentiation of periodontal tissue\u2010derived cells in the field of periodontitis"],"prefix":"10.1111","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-6141-1337","authenticated-orcid":false,"given":"Yinci","family":"Zhu","sequence":"first","affiliation":[{"name":"School of Stomatology Zunyi Medical University  Zunyi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoyan","family":"Guan","sequence":"additional","affiliation":[{"name":"Department of Orthodontics Affiliated Stomatological Hospital of Zunyi Medical University  Zunyi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaorui","family":"Geng","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology. 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