{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T15:11:04Z","timestamp":1782141064692,"version":"3.54.5"},"reference-count":68,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,12,20]],"date-time":"2023-12-20T00:00:00Z","timestamp":1703030400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100009110","name":"Natural Science Foundation of Xinjiang Uygur Autonomous Region","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009110","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Periodontal Research"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Investigating the changes in the oxidative stress levels and helper T lymphocyte (Th) subsets in patients with periodontitis and IgA nephropathy (IgAN) to determine their relationship.<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>IgAN has a high prevalence, poor prognosis, and no effective cure. Accumulating evidence has implicated a close relationship between periodontitis and chronic kidney diseases, in which both IgAN and chronic periodontitis show chronic inflammation and abnormal metabolism. However, few studies have been conducted on the relationship between the two diseases from this perspective.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We divided 86 IgAN patients into patients with healthy periodontium (IgAN\u2010H, <jats:italic>n<\/jats:italic>\u2009=\u200934) and patients with periodontitis IgAN (IgAN\u2010P, <jats:italic>n<\/jats:italic>\u2009=\u200952); moreover, we divided 72 systemically healthy participants into patients with periodontitis (H\u2010P, <jats:italic>n<\/jats:italic>\u2009=\u200935) and participants with healthy periodontium (H\u2010H, <jats:italic>n<\/jats:italic>\u2009=\u200937). The proportions of Th subsets in peripheral blood were estimated using flow cytometry. Cytokine levels in plasma were assessed using cytokine assay kits. Enzyme\u2010linked immunosorbent assay was used to evaluate the plasma levels of oxidative stress.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Our results from analyzing the Th cell subsets indicated that Th2 cell counts in the IgAN\u2010P group were significantly lower than those in the IgAN\u2010H group, while Th17 cell counts were increased (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). Moreover, the Th1\/Th2 ratio and interleukin\u20106 levels in the IgAN\u2010P group were significantly higher than those in the H\u2010H group (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01). Compared with that in the H\u2010H group, in the remaining three groups, plasma total oxidation state (TOS) levels were increased (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01), while plasma total antioxidant state (TAS) levels were decreased (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). Furthermore, estimated glomerular filtration rate was negatively correlated with the probing depth and gingival bleeding index. IgAN was a risk factor for periodontitis, while TAS was a protective factor for periodontitis. The oxidative stress index (OSI) might be valuable for distinguishing periodontitis patients from healthy controls (area under the receiver operator characteristic curve\u2009=\u20090.951).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>IgAN is an independent risk factor of periodontitis, and the Th17 cell\u2010mediated inflammatory response might be associated with the occurrence of periodontitis in patients with IgAN. Patients with coexisting IgAN and periodontitis exhibit increased oxidative stress, in which TOS and OSI are potential biomarkers for diagnosing periodontitis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jre.13216","type":"journal-article","created":{"date-parts":[[2023,12,20]],"date-time":"2023-12-20T12:37:05Z","timestamp":1703075825000},"page":"325-335","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Alterations in oxidative stress biomarkers and helper T\u2010cell subgroups in patients with periodontitis and <scp>IgA<\/scp> nephropathy"],"prefix":"10.1111","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3338-1973","authenticated-orcid":false,"given":"Jinfeng","family":"Li","sequence":"first","affiliation":[{"name":"Department of Stomatology the People's Hospital of Xinjiang Uygur Autonomous Region  Xinjiang China"},{"name":"Department of Periodontology, Faculty of Dental Science Kyushu University  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China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qianqiu","family":"Ou","sequence":"additional","affiliation":[{"name":"Department of Stomatology, School of Medicine Shihezi University  Xinjiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaotao","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Stomatology the People's Hospital of Xinjiang Uygur Autonomous Region  Xinjiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,12,20]]},"reference":[{"key":"e_1_2_9_2_1","article-title":"Editorial: periodontal disease \u2013 a public health problem","volume":"3","author":"Dumitrescu AL","year":"2015","journal-title":"Front Public Health"},{"issue":"7","key":"e_1_2_9_3_1","first-page":"403","article-title":"Disability\u2010adjusted life\u2010years (DALYs) for 315 diseases and injuries and healthy life expectancy (HALE) in Iran and its neighboring 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