{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T15:08:49Z","timestamp":1787756929626,"version":"build-2784847793"},"reference-count":56,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,12,15]],"date-time":"2023-12-15T00:00:00Z","timestamp":1702598400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Periodontal Research"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Objective<\/jats:title><jats:p>Observational studies have suggested a potential association between non\u2010alcoholic fatty liver disease (NAFLD) and chronic periodontitis (CP). However, these studies are prone to confounding factors. The aim of this study was to assess the causal relationship between NAFLD and CP using a two\u2010sample bidirectional Mendelian randomization (MR) analysis method.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Datasets of CP and NAFLD were retrieved from the European database, and instrumental variables (IVs) related to exposure were selected for the MR analysis. Sensitivity tests, including heterogeneity and horizontal pleiotropy tests, were conducted to ensure the consistency of the selected IVs, following which the analysis results were visualized.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Genetic variants associated with CP and NAFLD were identified as IVs, and the MR assessment was performed using the summary data (CP: 3046 cases and 195\u2009395 controls; NAFLD: 894 cases and 217\u2009898 controls). CP increased the risk of NAFLD (inverse variance weighted [IVW], <jats:italic>b<\/jats:italic>\u2009=\u20090.132\u2009&gt;\u20090, <jats:italic>p<\/jats:italic>\u2009=\u2009.006\u2009&lt;\u2009.05), whereas the reverse was not observed (IVW, <jats:italic>b<\/jats:italic>\u2009=\u2009\u22120.024\u2009&lt;\u20090, <jats:italic>p<\/jats:italic>\u2009=\u2009.081\u2009&gt;\u2009.05). The sensitivity analysis indicated no heterogeneity or horizontal pleiotropy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The MR analysis suggested that CP could increase the risk of NAFLD among European populations.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jre.13218","type":"journal-article","created":{"date-parts":[[2023,12,16]],"date-time":"2023-12-16T04:25:59Z","timestamp":1702700759000},"page":"346-354","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["A Mendelian randomization study between chronic periodontitis and non\u2010alcoholic fatty liver disease"],"prefix":"10.1111","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-4168-1500","authenticated-orcid":false,"given":"Li","family":"Tan","sequence":"first","affiliation":[{"name":"State Key Laboratory of Oral &amp; Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School &amp; Hospital of Stomatology Wuhan University  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunbo","family":"He","sequence":"additional","affiliation":[{"name":"National Clinical Research Center for Geriatric Disorders Xiangya Hospital  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianyi","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Zhongnan Hospital of Wuhan University, Wuhan University  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianhua","family":"Gao","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral &amp; Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School &amp; Hospital of Stomatology Wuhan University  Wuhan 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