{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T20:05:00Z","timestamp":1789416300039,"version":"build-2803163510"},"reference-count":151,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,2,28]],"date-time":"2024-02-28T00:00:00Z","timestamp":1709078400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U22A20314"],"award-info":[{"award-number":["U22A20314"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31971282"],"award-info":[{"award-number":["31971282"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81771082"],"award-info":[{"award-number":["81771082"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82101014"],"award-info":[{"award-number":["82101014"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005230","name":"Natural Science Foundation of Chongqing","doi-asserted-by":"publisher","award":["cstc2021jcyj\u2010bsh0005"],"award-info":[{"award-number":["cstc2021jcyj\u2010bsh0005"]}],"id":[{"id":"10.13039\/501100005230","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2021M700628"],"award-info":[{"award-number":["2021M700628"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Periodontal Research"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Lipotoxicity refers to the accumulation of lipids in tissues other than adipose tissue (body fat). It is one of the major pathophysiological mechanisms responsible for the progression of diabetes complications such as non\u2010alcoholic fatty liver disease and diabetic nephropathy. Accumulating evidence indicates that lipotoxicity also contributes significantly to the toxic effects of diabetes on periodontitis. Therefore, we reviewed the current in\u00a0vivo, in\u00a0vitro, and clinical evidence of the detrimental effects of lipotoxicity on periodontitis, focusing on its molecular mechanisms, especially oxidative and endoplasmic reticulum stress, inflammation, ceramides, adipokines, and programmed cell death pathways. By elucidating potential therapeutic strategies targeting lipotoxicity and describing their associated mechanisms and clinical outcomes, including metformin, statins, liraglutide, adiponectin, and omega\u20103 PUFA, this review seeks to provide a more comprehensive and effective treatment framework against diabetes\u2010associated periodontitis. Furthermore, the challenges and future research directions are proposed, aiming to contribute to a more profound understanding of the impact of lipotoxicity on periodontitis.<\/jats:p>","DOI":"10.1111\/jre.13242","type":"journal-article","created":{"date-parts":[[2024,2,29]],"date-time":"2024-02-29T02:24:10Z","timestamp":1709173450000},"page":"431-445","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Lipotoxicity: The missing link between diabetes and periodontitis?"],"prefix":"10.1111","volume":"59","author":[{"given":"Yu","family":"Sun","sequence":"first","affiliation":[{"name":"College of Stomatology Chongqing Medical University  Chongqing China"},{"name":"Chongqing Key Laboratory of Oral Diseases and Biomedical Sciences  Chongqing China"},{"name":"Chongqing Municipal Key Laboratory of Oral Biomedical Engineering of Higher Education  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanyuan","family":"Yin","sequence":"additional","affiliation":[{"name":"College of Stomatology Chongqing Medical University  Chongqing China"},{"name":"Chongqing Key Laboratory of Oral Diseases and Biomedical Sciences  Chongqing China"},{"name":"Chongqing Municipal Key Laboratory of Oral Biomedical Engineering of Higher Education  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sihan","family":"Yang","sequence":"additional","affiliation":[{"name":"College of Stomatology Chongqing Medical University  Chongqing China"},{"name":"Chongqing Key Laboratory of Oral Diseases and Biomedical Sciences  Chongqing China"},{"name":"Chongqing Municipal Key Laboratory of Oral Biomedical Engineering of Higher Education  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongqing","family":"Ai","sequence":"additional","affiliation":[{"name":"College of Stomatology Chongqing Medical University  Chongqing China"},{"name":"Chongqing Key Laboratory of Oral Diseases and Biomedical Sciences  Chongqing China"},{"name":"Chongqing Municipal Key Laboratory of Oral Biomedical Engineering of Higher Education  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han","family":"Qin","sequence":"additional","affiliation":[{"name":"College of Stomatology Chongqing Medical University  Chongqing China"},{"name":"Chongqing Key Laboratory of Oral Diseases and Biomedical Sciences  Chongqing China"},{"name":"Chongqing Municipal Key Laboratory of Oral Biomedical Engineering of Higher Education  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuyun","family":"Xia","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, The Second Affiliated Hospital Chongqing Medical University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohui","family":"Xu","sequence":"additional","affiliation":[{"name":"College of Stomatology Chongqing Medical University  Chongqing China"},{"name":"Chongqing Key Laboratory of Oral Diseases and Biomedical Sciences  Chongqing China"},{"name":"Chongqing Municipal Key Laboratory of Oral Biomedical Engineering of Higher Education  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0224-6640","authenticated-orcid":false,"given":"Jinlin","family":"Song","sequence":"additional","affiliation":[{"name":"College of Stomatology Chongqing Medical University  Chongqing China"},{"name":"Chongqing Key Laboratory of Oral Diseases and Biomedical Sciences  Chongqing China"},{"name":"Chongqing Municipal Key Laboratory of Oral Biomedical Engineering of Higher Education  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,2,28]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00592-018-1120-4"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0757.2000.2230104.x"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1210\/er.2007-0023"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcjd.2020.10.018"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature05482"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2019.09.016"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23137349"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2010-0017"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu11071664"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/1440-1681.13372"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/JPER.21-0004"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12792"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/odi.14766"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2014.11.008"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.2337\/diab.45.3.273"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.2337\/db09-1401"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22105375"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1080\/10715762.2020.1866756"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sdentj.2018.09.003"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/JPER.22-0416"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0757.2006.00178.x"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/jre.12576"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2022.04.039"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12711"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/9421019"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.2005.00818.x"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/JPER.20-0406"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.R067595"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/biof.135"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm3270"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M113.489310"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.026062"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00163.2022"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2022.110241"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.21037\/atm-22-6"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/jre.12232"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/cdd.2016.74"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2015.150413"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12297"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1111\/odi.13003"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2015.11.015"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2018.03.014"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.117.310581"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1186\/1743-7075-10-6"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.1836"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1111\/odi.12596"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1111\/jre.12636"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1111\/odi.14105"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.2150"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034515609882"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22116069"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034511405384"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-291X(03)00449-2"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-09654-4"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2019.05.008"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.plipres.2005.11.002"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbalip.2019.06.015"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00223-015-0097-z"},{"issue":"24","key":"e_1_2_9_60_1","first-page":"12938","article-title":"Myriocin alleviates oleic\/palmitate induced chondrocyte degeneration via the suppression of ceramide","volume":"24","author":"Ma H","year":"2020","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"e_1_2_9_61_1","doi-asserted-by":"publisher","DOI":"10.1111\/jre.12951"},{"key":"e_1_2_9_62_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0030-1255034"},{"key":"e_1_2_9_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2010.08.001"},{"key":"e_1_2_9_64_1","doi-asserted-by":"publisher","DOI":"10.3858\/emm.2012.44.9.064"},{"key":"e_1_2_9_65_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2567.2008.02892.x"},{"key":"e_1_2_9_66_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/796565"},{"key":"e_1_2_9_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.orcp.2011.11.005"},{"key":"e_1_2_9_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2021.111358"},{"key":"e_1_2_9_69_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.2009.01222.x"},{"key":"e_1_2_9_70_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1097243"},{"key":"e_1_2_9_71_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-016-1871-7"},{"key":"e_1_2_9_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2021.119042"},{"key":"e_1_2_9_73_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2015.140434"},{"key":"e_1_2_9_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2021.120262"},{"key":"e_1_2_9_75_1","doi-asserted-by":"publisher","DOI":"10.1177\/00220345211059418"},{"key":"e_1_2_9_76_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2017.170042"},{"key":"e_1_2_9_77_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2796.2005.01570.x"},{"key":"e_1_2_9_78_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2009.12.022"},{"key":"e_1_2_9_79_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41580-020-0250-z"},{"key":"e_1_2_9_80_1","doi-asserted-by":"publisher","DOI":"10.1177\/154405910608500103"},{"key":"e_1_2_9_81_1","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.33.545"},{"key":"e_1_2_9_82_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034510362960"},{"key":"e_1_2_9_83_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M308102200"},{"key":"e_1_2_9_84_1","doi-asserted-by":"publisher","DOI":"10.1038\/cr.2016.100"},{"key":"e_1_2_9_85_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.663037"},{"key":"e_1_2_9_86_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2021.107456"},{"key":"e_1_2_9_87_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2014.140403"},{"key":"e_1_2_9_88_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13517"},{"key":"e_1_2_9_89_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2020.104763"},{"key":"e_1_2_9_90_1","doi-asserted-by":"publisher","DOI":"10.1111\/odi.14648"},{"key":"e_1_2_9_91_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcb.2015.10.014"},{"key":"e_1_2_9_92_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2017.09.021"},{"key":"e_1_2_9_93_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhazmat.2019.121390"},{"key":"e_1_2_9_94_1","doi-asserted-by":"publisher","DOI":"10.1111\/febs.16772"},{"key":"e_1_2_9_95_1","doi-asserted-by":"publisher","DOI":"10.1111\/liv.14428"},{"key":"e_1_2_9_96_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0271202"},{"key":"e_1_2_9_97_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbiomolbio.2020.04.001"},{"key":"e_1_2_9_98_1","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/9067610"},{"key":"e_1_2_9_99_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41420-020-00356-1"},{"key":"e_1_2_9_100_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2019.10.012"},{"key":"e_1_2_9_101_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2016.07.010"},{"key":"e_1_2_9_102_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-39721-1"},{"key":"e_1_2_9_103_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00109-021-02126-7"},{"key":"e_1_2_9_104_1","doi-asserted-by":"publisher","DOI":"10.2147\/DMSO.S300388"},{"key":"e_1_2_9_105_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2014.01.027"},{"key":"e_1_2_9_106_1","doi-asserted-by":"publisher","DOI":"10.1158\/1535-7163.MCT-17-0173"},{"key":"e_1_2_9_107_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.leukres.2015.06.002"},{"key":"e_1_2_9_108_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm2970"},{"key":"e_1_2_9_109_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41574-019-0242-2"},{"issue":"4","key":"e_1_2_9_110_1","doi-asserted-by":"crossref","first-page":"6S28","DOI":"10.1016\/S1262-3636(03)72785-2","article-title":"Reducing insulin resistance with metformin: the evidence today","volume":"29","author":"Giannarelli R","year":"2003","journal-title":"Diabetes Metab"},{"key":"e_1_2_9_111_1","doi-asserted-by":"publisher","DOI":"10.2337\/db13-0194"},{"key":"e_1_2_9_112_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0097868"},{"key":"e_1_2_9_113_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2021.01.033"},{"key":"e_1_2_9_114_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2019.111717"},{"key":"e_1_2_9_115_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.2c08146"},{"key":"e_1_2_9_116_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2017.170168"},{"key":"e_1_2_9_117_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2010.12.003"},{"key":"e_1_2_9_118_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19113488"},{"key":"e_1_2_9_119_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmet.2020.101102"},{"key":"e_1_2_9_120_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2018.03.001"},{"key":"e_1_2_9_121_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trsl.2020.07.008"},{"key":"e_1_2_9_122_1","doi-asserted-by":"publisher","DOI":"10.2337\/db09-0685"},{"key":"e_1_2_9_123_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2021.622737"},{"key":"e_1_2_9_124_1","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/8843310"},{"key":"e_1_2_9_125_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdent.2020.103310"},{"key":"e_1_2_9_126_1","doi-asserted-by":"publisher","DOI":"10.1111\/jre.12607"},{"key":"e_1_2_9_127_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2015.150278"},{"key":"e_1_2_9_128_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mam.2018.01.004"},{"key":"e_1_2_9_129_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mam.2018.03.001"},{"key":"e_1_2_9_130_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2019.104462"},{"key":"e_1_2_9_131_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu12092614"},{"key":"e_1_2_9_132_1","doi-asserted-by":"publisher","DOI":"10.1002\/JPER.19-0613"},{"key":"e_1_2_9_133_1","doi-asserted-by":"publisher","DOI":"10.1002\/JPER.19-0063"},{"key":"e_1_2_9_134_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2017.01.006"},{"key":"e_1_2_9_135_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00115.2010"},{"key":"e_1_2_9_136_1","doi-asserted-by":"publisher","DOI":"10.1038\/90984"},{"key":"e_1_2_9_137_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034518818449"},{"key":"e_1_2_9_138_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.15277"},{"key":"e_1_2_9_139_1","doi-asserted-by":"publisher","DOI":"10.1111\/jre.12969"},{"key":"e_1_2_9_140_1","doi-asserted-by":"publisher","DOI":"10.1177\/1074248417745357"},{"key":"e_1_2_9_141_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbalip.2020.158755"},{"key":"e_1_2_9_142_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-018-2354-9"},{"key":"e_1_2_9_143_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2017.05.022"},{"key":"e_1_2_9_144_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10753-016-0390-7"},{"key":"e_1_2_9_145_1","doi-asserted-by":"publisher","DOI":"10.1111\/odi.12474"},{"key":"e_1_2_9_146_1","doi-asserted-by":"publisher","DOI":"10.1111\/jre.12513"},{"key":"e_1_2_9_147_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2012.110721"},{"key":"e_1_2_9_148_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2013.12.009"},{"key":"e_1_2_9_149_1","doi-asserted-by":"publisher","DOI":"10.1111\/jre.12132"},{"key":"e_1_2_9_150_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2017.06.014"},{"key":"e_1_2_9_151_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22115876"},{"key":"e_1_2_9_152_1","doi-asserted-by":"publisher","DOI":"10.3389\/froh.2022.821326"}],"container-title":["Journal of Periodontal Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jre.13242","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,23]],"date-time":"2024-05-23T13:40:33Z","timestamp":1716471633000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jre.13242"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,28]]},"references-count":151,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,6]]}},"alternative-id":["10.1111\/jre.13242"],"URL":"https:\/\/doi.org\/10.1111\/jre.13242","archive":["Portico"],"relation":{},"ISSN":["0022-3484","1600-0765"],"issn-type":[{"value":"0022-3484","type":"print"},{"value":"1600-0765","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,2,28]]},"assertion":[{"value":"2023-05-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-01-14","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-02-28","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}