{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T13:17:39Z","timestamp":1787318259302,"version":"build-2736575974"},"reference-count":58,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,2,14]],"date-time":"2024-02-14T00:00:00Z","timestamp":1707868800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100005322","name":"Recep Tayyip Erdogan \u00dcniversitesi","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Periodontal Research"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Objective<\/jats:title>\n                    <jats:p>Periodontitis is an inflammatory disease that destroys periodontal tissues. Interleukin\u201020 (IL\u201020), on the other hand, is known as a potent angiogenic, chemotactic, and pro\u2010inflammatory cytokine associated with various chronic inflammatory disorders. IL\u201020 has a significant role in the regulation of osteoclastogenesis and osteoblastogenesis. This study aimed to evaluate the effect of IL\u201020 on periodontal destruction.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      In this study, a total of 60 participants were included, 30 of whom were systemically and periodontally healthy (control group), and 30 were systemically healthy but had periodontitis (periodontitis group). Gingival crevicular fluid (GCF) and serum samples were collected from the participants for biochemical analysis. Enzyme\u2010linked immunosorbent assay was used to determine the levels of IL\u201020, tumor necrosis factor (TNF)\u2010\u03b1, IL1\u03b2\/IL\u201010, RANKL\/osteoprotegerin (OPG), and matrix metalloproteinase\u20108 (MMP8). For statistical analysis, the independent\n                      <jats:italic>t<\/jats:italic>\n                      \u2010test, Pearson correlation coefficients, and the Chi\u2010square test were used.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>GCF IL\u201020, RANKL, RANKL\/OPG, serum IL\u201020, RANKL, RANKL\/OPG, MMP\u20108, TNF\u2010\u03b1, IL\u20101B, and IL\u20101\u03b2\/IL\u201010 values were found to be statistically significantly higher in the periodontitis group than in the control group. GCF OPG and serum IL\u201010 values were found to be statistically significantly higher in the control group than in the periodontitis group. No statistically significant difference was observed between the groups in serum OPG values. A statistically significantly positive correlation was observed between serum IL\u201020 value and serum RANKL, RANKL\/OPG, MMP\u20108, TNF\u2010\u03b1, IL\u20101\u03b2 values, and periodontal clinical parameters. The ROC curves showed: AUC\u2009=\u20090.788 for GCF IL\u201020, and AUC\u2009=\u20091.000 for serum IL\u201020.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>According to the results of the study, IL\u201020 was found to be associated with periodontitis. The role of IL\u201020 in periodontal pathogenesis is related to osteoclastogenesis and collagen degradation. It is conceivable that IL\u201020 may increase bone destruction by both affecting the RANKL\/OPG ratio and proinflammatory cytokines.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jre.13243","type":"journal-article","created":{"date-parts":[[2024,2,14]],"date-time":"2024-02-14T23:41:30Z","timestamp":1707954090000},"page":"480-490","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["The effect of interleukin\u201020 on periodontal tissue destruction in individuals with periodontitis"],"prefix":"10.1111","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2532-2896","authenticated-orcid":false,"given":"H.","family":"Yemenoglu","sequence":"first","affiliation":[{"name":"Department of Periodontology, Faculty of Dentistry Recep Tayyip Erdo\u011fan University  Rize 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