{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T19:38:33Z","timestamp":1781293113656,"version":"3.54.1"},"reference-count":45,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,2,14]],"date-time":"2024-02-14T00:00:00Z","timestamp":1707868800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Periodontal Research"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>This study aimed to evaluate the regenerative capacities of octacalcium phosphate collagen composite (OCP\/Col) in one\u2010wall intrabony defects in dogs. The background data discuss the present state of the field: No study has assessed the efficacy of OCP\/Col for periodontal regeneration therapy despite the fact that OCP\/Col has proved to be efficient for bone regeneration.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In six beagle dogs, the mandibular left third premolars were extracted 12\u2009weeks before the experimental surgery. Standardized bone defects (5\u2009mm in height and 4\u2009mm in width) were simulated on the distal surface of the second premolars and mesially on the fourth premolars. The defect was filled with either OCP\/Col (experimental group) or left empty (control group). Histological and histomorphometric characteristics were compared 8\u2009weeks after surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>No infectious or ankylotic complications were detected at any of the tested sites. The experimental group exhibited a significantly greater volume, height, and area of newly formed bone than the control group. The former also showed a greater height of the newly formed cementum than the latter, although the results were not statistically significant. The newly formed periodontal ligaments were inserted into newly formed bone and cementum in the experimental group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>OCP\/Col demonstrated high efficacy for bone and periodontal tissue regeneration that can be successfully applied for one\u2010wall intrabony defects.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jre.13245","type":"journal-article","created":{"date-parts":[[2024,2,15]],"date-time":"2024-02-15T04:58:50Z","timestamp":1707973130000},"page":"521-529","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Octacalcium phosphate collagen composite for periodontal regeneration in a canine one\u2010wall intrabony defect"],"prefix":"10.1111","volume":"59","author":[{"given":"Daichi","family":"Yamaki","sequence":"first","affiliation":[{"name":"Department of Periodontology, Graduate School of Medical and Dental Science Tokyo Medical and Dental 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