{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T16:51:31Z","timestamp":1789750291009,"version":"4.0.1"},"reference-count":50,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,4,2]],"date-time":"2024-04-02T00:00:00Z","timestamp":1712016000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Periodontal Research"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Objective<\/jats:title><jats:p>The biological effects of atmospheric plasma (cold plasma) show its applicability for controlling the etiological factors that involve tissue repair. Thus, the study evaluated the effect of atmospheric plasma therapy in the control of tissue inflammation and bone remodeling in experimental periodontitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Fifty\u2010six rats were subjected to ligation in the cervical region of the first maxillary molars (8\u2009weeks). The animals were divided into two groups (<jats:italic>n<\/jats:italic>\u2009=\u200928): periodontitis without treatment group (P group), and periodontitis with atmospheric plasma treatment group (P\u2009+\u2009AP group). Tissue samples were collected at 2 and 4\u2009weeks after treatment to analyze the inflammation and bone remodeling by biochemical, histomorphometric, and immunohistochemical analyses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Inflammatory infiltration in the gingival and periodontal ligament was lower in the P\u2009+\u2009AP group than in the P group (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.05). The MPO and NAG levels were higher in the P\u2009+\u2009AP group compared to P group (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.05). At 4\u2009weeks, the TNF\u2010\u03b1 level was lower and the IL\u201010 level was higher in the P\u2009+\u2009AP group compared to P group (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.05). In the P\u2009+\u2009AP group, the IL\u20101\u03b2 level increased in the second week and decreased in the fourth week (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.05), the number of blood vessels was high in the gingival and periodontal ligament in the second and fourth week (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.05); and the number of fibroblasts in the gingival tissue was low in the fourth week, and higher in the periodontal tissue in both period (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.05). Regarding bone remodeling, the RANK and RANKL levels decreased in the P\u2009+\u2009AP group (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.05). The OPG level did not differ between the P and P\u2009+\u2009AP groups (<jats:italic>p<\/jats:italic>\u2009&gt;\u2009.05), but decreased from the second to the fourth experimental week in P\u2009+\u2009AP group (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The treatment of experimental periodontitis with atmospheric plasma for 4\u2009weeks modulated the inflammatory response to favor the repair process and decreased the bone resorption biomarkers, indicating a better control of bone remodeling in periodontal disease.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jre.13248","type":"journal-article","created":{"date-parts":[[2024,4,3]],"date-time":"2024-04-03T03:48:50Z","timestamp":1712116130000},"page":"738-748","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Analysis of inflammation and bone remodeling of atmospheric plasma therapy in experimental periodontitis"],"prefix":"10.1111","volume":"59","author":[{"given":"Ildamara Canoa","family":"de Oliveira","sequence":"first","affiliation":[{"name":"Graduate Program in Biomedical Sciences University Center of Herm\u00ednio Ometto Foundation \u2013 FHO  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariana","family":"Zanco","sequence":"additional","affiliation":[{"name":"Graduate Program in Biomedical Sciences University Center of Herm\u00ednio Ometto Foundation \u2013 FHO  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliana","family":"Lopes","sequence":"additional","affiliation":[{"name":"Graduate Program in Biomedical Sciences University Center of Herm\u00ednio Ometto Foundation \u2013 FHO  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milena Paloma","family":"Sambo","sequence":"additional","affiliation":[{"name":"Graduate Program in Biomedical 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