{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T01:43:36Z","timestamp":1776649416603,"version":"3.51.2"},"reference-count":48,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,3,19]],"date-time":"2024-03-19T00:00:00Z","timestamp":1710806400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81870773"],"award-info":[{"award-number":["81870773"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82071116"],"award-info":[{"award-number":["82071116"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Periodontal Research"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Periodontitis is characterized by local inflammatory conditions in the periodontium, its severe form has been associated with elevated systemic inflammatory markers. However, the long\u2010term effects of periodontal inflammation control on systemic inflammatory markers are unclear.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>This study aimed to investigate the long\u2010term effects of periodontal therapy on the levels of peripheral venous blood inflammatory markers in patients with generalized aggressive periodontitis (GAgP), all of whom were now diagnosed as Stage III or IV Grade C periodontitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients with GAgP were consecutively recruited from April 2013 to August 2014 (T0). Active periodontal treatment (APT) was provided, and follow\u2010ups were conducted over a 3\u2010 to 5\u2010year period (T1). Clinical parameters were assessed and fasting venous blood was collected at T0 and T1. Complete blood cell counts were obtained, and biochemical analyses were performed to evaluate the levels of serum components. The correlations between probing depth (PD) and hematological parameters were analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 49 patients with GAgP completed APT and follow\u2010ups. Probing depth (PD) reduced from 5.10\u2009\u00b1\u20091.07\u2009mm at T0 to 3.15\u2009\u00b1\u20090.65\u2009mm at T1. For every 1\u2010mm reduction in PD after treatment, the neutrophil count, neutrophil\u2010lymphocyte ratio, and total protein concentration were reduced by 0.33\u2009\u00d7\u200910<jats:sup>9<\/jats:sup>\/L, 0.26, and 1.18\u2009g\/L, respectively. In contrast, the albumin\/globulin ratio increased by 0.10.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study indicated that periodontal therapy may have beneficial effects on peripheral venous blood inflammatory markers in patients with GAgP during long\u2010term observation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jre.13251","type":"journal-article","created":{"date-parts":[[2024,3,19]],"date-time":"2024-03-19T08:44:07Z","timestamp":1710837847000},"page":"689-697","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["The long\u2010term effect of periodontitis treatment on changes in blood inflammatory markers in patients with generalized aggressive periodontitis"],"prefix":"10.1111","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-8384-4088","authenticated-orcid":false,"given":"Xiancheng","family":"Zeng","sequence":"first","affiliation":[{"name":"Department of 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