{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T23:39:59Z","timestamp":1792021199364,"version":"4.4.0"},"reference-count":40,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,5,6]],"date-time":"2024-05-06T00:00:00Z","timestamp":1714953600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000072","name":"National Institute of Dental and Craniofacial Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000072","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Periodontal Research"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To explore the influence of gender on periodontal treatment outcomes in a dataset of eight RCTs conducted in Brazil, United States, and Germany.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Clinical parameters were compared between men and women with stages III\/IV grades B\/C generalized periodontitis at baseline and 1\u2010year post\u2010therapy, including scaling and root planing with or without antibiotics.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Data from 1042 patients were analyzed. Men presented a tendency towards higher probing depth (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.07, effect size\u2009=\u20090.11) and clinical attachment level (CAL) than women at baseline (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.01, effect size\u2009=\u20090.16). Males also presented statistically significantly lower CAL gain at sites with CAL of 4\u20136\u2009mm at 1\u2010year post\u2010therapy (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.001, effect size\u2009=\u20090.20). Among patients with Grade B periodontitis who took antibiotics, a higher frequency of women achieved the endpoint for treatment (i.e., \u22644 sites PD \u22655\u2009mm) at 1\u2009year than men (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.05, effect size\u2009=\u20090.12).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Men enrolled in RCTs showed a slightly inferior clinical response to periodontal therapy in a limited number of sub\u2010analyses when compared to women. These small differences did not appear to be clinically relevant. Although gender did not dictate the clinical response to periodontal treatment in this population, our findings suggest that future research should continue to explore this topic.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jre.13272","type":"journal-article","created":{"date-parts":[[2024,5,6]],"date-time":"2024-05-06T07:58:03Z","timestamp":1714982283000},"page":"1175-1183","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Influence of gender on periodontal outcomes: A retrospective analysis of eight randomized clinical trials"],"prefix":"10.1111","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2041-9426","authenticated-orcid":false,"given":"Nidia","family":"Castro dos Santos","sequence":"first","affiliation":[{"name":"Department of Periodontology, Dental Research Division Guarulhos University  Guarulhos S\u00e3o Paulo Brazil"},{"name":"The Forsyth Institute  Cambridge Massachusetts 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