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The present scoping review provides current perspectives on surface modifications of dental implants, their impact on the osseointegration process, and the interaction between implant surface properties and epigenetics, also in peri\u2010implant diseases. Findings of this review demonstrate the impact of innovative surface treatments on the epigenetic mechanisms of cells, showing promising results in the early stages of osseointegration. Dental implant surfaces with properties of hydrophilicity, nanotexturization, multifunctional coatings, and incorporated drug\u2010release systems have demonstrated favorable outcomes for early bone adhesion, increased antibacterial features, and improved osseointegration. The interaction between modified surface morphologies, different chemical surface energies, and\/or release of molecules within the oral tissues has been shown to influence epigenetic mechanisms of the surrounding tissues caused by a physical\u2013chemical interaction. Epigenetic changes around dental implants in the state of health and disease are different. In conclusion, emerging approaches in surface modifications for dental implants functionalized with epigenetics have great potential with a significant impact on modulating bone healing during osseointegration.<\/jats:p>","DOI":"10.1111\/jre.13273","type":"journal-article","created":{"date-parts":[[2024,5,15]],"date-time":"2024-05-15T04:33:53Z","timestamp":1715747633000},"page":"1095-1114","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":49,"title":["Implant surface modifications and their impact on osseointegration and peri\u2010implant diseases through epigenetic changes: A scoping review"],"prefix":"10.1111","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0493-8891","authenticated-orcid":false,"given":"Marcel F.","family":"Kunrath","sequence":"first","affiliation":[{"name":"Department of Biomaterials, Institute of Clinical Sciences, Sahlgrenska Academy University of Gothenburg  G\u00f6teborg Sweden"},{"name":"Department of Dentistry, School of Health and Life Sciences Pontifical Catholic University of Rio Grande do Sul (PUCRS)  Porto Alegre Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Garaicoa\u2010Pazmino","sequence":"additional","affiliation":[{"name":"Department of Periodontics University of Iowa College of Dentistry  Iowa City Iowa USA"},{"name":"Research Center, School of Dentistry Espiritu Santo University  Samborond\u00f3n Ecuador"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula Milena","family":"Giraldo\u2010Osorno","sequence":"additional","affiliation":[{"name":"Department of Biomaterials, Institute of Clinical Sciences, Sahlgrenska Academy University of Gothenburg  G\u00f6teborg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aya","family":"Haj Mustafa","sequence":"additional","affiliation":[{"name":"Institute of Odontology, Sahlgrenska Academy University of Gothenburg  G\u00f6teborg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christer","family":"Dahlin","sequence":"additional","affiliation":[{"name":"Department of Biomaterials, Institute of Clinical Sciences, Sahlgrenska Academy University of Gothenburg  G\u00f6teborg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lena","family":"Larsson","sequence":"additional","affiliation":[{"name":"Department of Oral Biochemistry, Institute of Odontology, Sahlgrenska Academy University of Gothenburg  G\u00f6teborg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farah","family":"Asa'ad","sequence":"additional","affiliation":[{"name":"Department of Biomaterials, Institute of Clinical Sciences, Sahlgrenska Academy University of Gothenburg  G\u00f6teborg Sweden"},{"name":"Department of Oral Biochemistry, Institute of Odontology, Sahlgrenska Academy University of Gothenburg  G\u00f6teborg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,5,15]]},"reference":[{"issue":"1","key":"e_1_2_13_2_1","first-page":"15","article-title":"The role of implant surface modifications, shape and material on the success of osseointegrated dental implants. 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