{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T13:42:04Z","timestamp":1787060524711,"version":"build-2736575974"},"reference-count":57,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,5,14]],"date-time":"2024-05-14T00:00:00Z","timestamp":1715644800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Periodontal Research"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>This study aimed to investigate the effects of Umbelliferone (UMB) on the inflammation underlying alveolar bone resorption in mouse periodontitis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Male Swiss mice subjected to a ligature of molars were grouped as non\u2010treated (NT), received UMB (15, 45, or 135\u2009mg\/kg) or saline daily for 7\u2009days, respectively, and were compared with na\u00efve mice as control. Gingival tissues were evaluated by myeloperoxidase (MPO) activity and interleukin\u20101\u03b2 level by ELISA. The bone resorption was directly assessed on the region between the cement\u2013enamel junction and the alveolar bone crest. Microscopically, histomorphometry of the furcation region, immunofluorescence for nuclear factor\u2010kappa B (NF\u2010\u0138B), and immunohistochemistry for tartrate\u2010resistant acid phosphatase (TRAP), and cathepsin K (CTSK) were performed. Systemically, body mass variation and leukogram were analyzed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Periodontitis significantly increased MPO activity, interleukin\u20101\u03b2 level, and NF\u2010\u0138B+ immunofluorescence, and induced severe alveolar bone and furcation resorptions, besides increased TRAP+ and CTSK+ cells compared with na\u00efve. UMB significantly prevented the inflammation by reducing MPO activity, interleukin\u20101\u03b2 level, and NF\u2010\u0138B+ intensity, besides reduction of resorption of alveolar bone and furcation area, and TRAP+ and CTSK+ cells compared with the NT group. Periodontitis or UMB treatment did not affect the animals systemically.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>UMB improved periodontitis by reducing inflammation and bone markers.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jre.13277","type":"journal-article","created":{"date-parts":[[2024,5,14]],"date-time":"2024-05-14T08:18:25Z","timestamp":1715674705000},"page":"982-992","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Umbelliferone reduces inflammation and ligature\u2010induced osteoclastic alveolar bone resorption in mice"],"prefix":"10.1111","volume":"59","author":[{"given":"Samia Jessica Silva","family":"Tavares","sequence":"first","affiliation":[{"name":"Faculty of Pharmacy, Dentistry and Nursing Course of Dentistry, Federal University of Cear\u00e1  Fortaleza 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Roriz","family":"Fonteles","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy, Dentistry and Nursing Course of Dentistry, Federal University of Cear\u00e1  Fortaleza Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deysi Viviana Tenazoa","family":"Wong","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Department of Physiology and Pharmacology Federal University of Cear\u00e1  Fortaleza Brazil"},{"name":"Center for Drug Research and Development Federal University of Cear\u00e1  Fortaleza Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto C\u00e9sar Pereira","family":"Lima\u2010J\u00fanior","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Department of Physiology and Pharmacology Federal University of Cear\u00e1  Fortaleza Brazil"},{"name":"Center for Drug Research and Development Federal University of Cear\u00e1  Fortaleza 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