{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T05:37:25Z","timestamp":1790919445160,"version":"4.1.0"},"reference-count":47,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,4,26]],"date-time":"2024-04-26T00:00:00Z","timestamp":1714089600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Periodontal Research"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>This study evaluated the efficacy of quadrantwise subgingival instrumentation (Q\u2010SI) versus one\u2010stage full\u2010mouth subgingival instrumentation (FM\u2010SI) on probing depth and periodontal pathogen reduction over a 6\u2010month follow\u2010up period, as well as whether baseline periodontal pathogens influenced the impact of periodontal treatment protocols on outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients with periodontitis were randomized to receive Q\u2010SI (<jats:italic>n<\/jats:italic>\u2009=\u200943) or FM\u2010SI (<jats:italic>n<\/jats:italic>\u2009=\u200945). Patients were instructed and motivated to maintain optimal oral hygiene during the treatment sessions. Clinical (probing pocket depth [PPD], clinical attachment loss [CAL], and bleeding on probing [BOP]) and periodontal pathogens were assessed at baseline and after 30, 90, and 180\u2009days. Total bacterial load and periodontal pathogens were analysed via real\u2010time PCR.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At the 6\u2010month follow\u2010up, the median PPD decreased from 4.8\u2009mm (interquartile range [IQR]: 4.3\u20135.2) to 2.6\u2009mm (IQR: 2.3\u20132.9) in FM\u2010SI patients and from 4.7\u2009mm (IQR: 4.1\u20135.2) to 3.2\u2009mm (IQR: 2.4\u20133.5) in Q\u2010SI patients (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001). At 6\u2009months, FM\u2010SI was more effective at reducing the median proportions of <jats:italic>Porphyromonas gingivalis<\/jats:italic> (<jats:italic>Pg<\/jats:italic>), <jats:italic>Aggregatibacter actinocomyctemcomitans<\/jats:italic>, and <jats:italic>Tannerella forsythia<\/jats:italic> (<jats:italic>Tf<\/jats:italic>) (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001 for each value). Multilevel linear regression analysis demonstrated that high baseline PPD (<jats:italic>p<\/jats:italic>\u2009=\u2009.029), <jats:italic>Pg<\/jats:italic> (<jats:italic>p<\/jats:italic>\u2009=\u2009.014), and <jats:italic>Tf<\/jats:italic> (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001) levels and the FM\u2010SI protocol (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001) were statistically significant predictors of PPD reduction at 6\u2009months. Furthermore, PPD reduction was significantly greater in the FM\u2010SI group when lower baseline <jats:italic>Pg<\/jats:italic> levels were detected.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The FM\u2010SI was more effective than the Q\u2010SI in reducing the mean PPD and number of periodontal pathogens in periodontitis patients over a 6\u2010month follow\u2010up period. Higher baseline PPD and <jats:italic>Pg<\/jats:italic> levels had a negative impact on PPD reduction at 6\u2009months after FM\u2010SI.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jre.13279","type":"journal-article","created":{"date-parts":[[2024,4,26]],"date-time":"2024-04-26T08:49:55Z","timestamp":1714121395000},"page":"647-656","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":53,"title":["Effect of quadrantwise versus full\u2010mouth subgingival instrumentation on clinical and microbiological parameters in periodontitis patients: A randomized clinical trial"],"prefix":"10.1111","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4267-6992","authenticated-orcid":false,"given":"Gaetano","family":"Isola","sequence":"first","affiliation":[{"name":"Department of General Surgery and Surgical\u2010Medical Specialties, Unit of Periodontology, School of Dentistry University of Catania  Catania 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