{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T00:21:27Z","timestamp":1790295687412,"version":"4.1.0"},"reference-count":54,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,5,6]],"date-time":"2024-05-06T00:00:00Z","timestamp":1714953600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Periodontal Research"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>The aim of this study was to evaluate the utility of using MRI\u2010derived tooth count, an indirect and nonspecific indicator of oral\/periodontal health, and brain age gap (BAG), an MRI\u2010based measure of premature brain aging, in predicting cognition in a population of otherwise healthy adults.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective study utilized data from 329 participants from the University of South Carolina's Aging Brain Cohort Repository. Participants underwent neuropsychological testing including the Montreal Cognitive Assessment (MoCA), completed an oral\/periodontal health questionnaire, and submitted to high\u2010resolution structural MRI imaging. The study compared variability on cognitive scores (MoCA) accounted for by MRI\u2010derived BAG, MRI\u2010derived total tooth count, and self\u2010reported oral\/periodontal health.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      We report a significant positive correlation between the total number of teeth and MoCA total scores after controlling for age, sex, and race, indicating a robust relationship between tooth count and cognition,\n                      <jats:italic>r<\/jats:italic>\n                      (208)\u2009=\u2009.233,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.001. In a subsample of participants identified as being at risk for MCI (MoCA\u2009&lt;=\u200925,\n                      <jats:italic>N<\/jats:italic>\n                      \u2009=\u200936) inclusion of MRI\u2010based tooth count resulted in an\n                      <jats:italic>R<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      change of .192 (\n                      <jats:italic>H<\/jats:italic>\n                      <jats:sub>0<\/jats:sub>\n                      \u2009=\u20090.138\u2009\u2192\u2009\n                      <jats:italic>H<\/jats:italic>\n                      <jats:sub>1<\/jats:sub>\n                      \u2009=\u20090.330),\n                      <jats:italic>F<\/jats:italic>\n                      (1,31)\u2009=\u20098.86,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.006. Notably, inclusion of BAG, a valid and reliable measure of overall brain health, did not significantly improve prediction of MoCA scores in similar linear regression models.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our data support the idea that inclusion of MRI\u2010based total tooth count may enhance the ability to predict clinically meaningful differences in cognitive abilities in healthy adults. This study contributes to the growing body of evidence linking oral\/periodontal health with cognitive function.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jre.13280","type":"journal-article","created":{"date-parts":[[2024,5,6]],"date-time":"2024-05-06T08:08:01Z","timestamp":1714982881000},"page":"1184-1194","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Exploring the link between tooth loss, cognitive function, and\u00a0brain wellness in the context of healthy aging"],"prefix":"10.1111","volume":"59","author":[{"given":"Roger D.","family":"Newman\u2010Norlund","sequence":"first","affiliation":[{"name":"Department of Psychology, College of Arts and Sciences University of South Carolina  Columbia South Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Santosh","family":"Kudaravalli","sequence":"additional","affiliation":[{"name":"Department of Psychology, College of Arts and Sciences University of South Carolina  Columbia South Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anwar T.","family":"Merchant","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, Arnold School of Public Health University of South Carolina  Columbia South Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julius","family":"Fridriksson","sequence":"additional","affiliation":[{"name":"Department of Communication Sciences and Disorders, College of Arts and Sciences University of South Carolina  Columbia South Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chris","family":"Rorden","sequence":"additional","affiliation":[{"name":"Department of Psychology, College of Arts and Sciences University of South Carolina  Columbia South Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,5,6]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ssmph.2022.101052"},{"key":"e_1_2_9_3_1","volume-title":"Dementia: A Public Health Priority","author":"World Health Organization","year":"2012"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41514-024-00136-6"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1590\/1980-57642020dn14-020001"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13195-020-00706-2"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0267190508080045"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.3928\/0098-9134-19910101-06"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/jamia\/ocaa174"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1080\/13607863.2018.1544212"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2021.697234"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1080\/01688639008400980"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1080\/13607863.2014.915923"},{"key":"e_1_2_9_14_1","first-page":"125","article-title":"Clinical features and multidisciplinary approaches to dementia care","volume":"4","author":"Grand JH","year":"2011","journal-title":"J Multidiscip Healthc"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/psyg.12484"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1177\/1715163517690745"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.108.531343"},{"issue":"2","key":"e_1_2_9_18_1","first-page":"119","article-title":"Mild cognitive impairment: a concept useful for early detection and intervention of dementia","volume":"25","author":"Chen W","year":"2013","journal-title":"Shanghai Arch Psychiatry"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgs.18029"},{"issue":"7","key":"e_1_2_9_20_1","article-title":"Mini\u2010mental state examination (MMSE) for the early detection of dementia in people with mild cognitive impairment (MCI)","volume":"7","author":"Arevalo\u2010Rodriguez I","year":"2021","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1109\/JBHI.2022.3185798"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2023.1256389"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-018-9016-3"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-230733"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2019.00789"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.3390\/jpm12111850"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41398-020-01004-z"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.4103\/1947-2714.159325"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.14283\/jpad.2023.82"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.13683"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1159\/000535776"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.2005.53221.x"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000208020"},{"issue":"7","key":"e_1_2_9_34_1","article-title":"Montreal cognitive assessment for the detection of dementia","volume":"7","author":"Davis DH","year":"2021","journal-title":"Cochrane Database Syst Rev"},{"issue":"1","key":"e_1_2_9_35_1","first-page":"S5","article-title":"National Study of adult Oral health 2017\u201018: study design and methods","volume":"65","author":"Chrisopoulos S","year":"2020","journal-title":"Aust Dent J"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2022.103175"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-14904-5"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2011.09.015"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13851"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgs.17978"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-021-04318-4"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.14219\/jada.archive.2007.0046"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/afaa025"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.18632\/aging.202843"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.archger.2016.12.006"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2023.101986"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2022.3919"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1038\/sdata.2016.44"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13779"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13155"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12603-022-1783-y"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12955-014-0165-5"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1111\/joor.12984"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1259\/dmfr.20120321"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2011.02.022"}],"container-title":["Journal of Periodontal Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jre.13280","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T09:48:06Z","timestamp":1766396886000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jre.13280"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,6]]},"references-count":54,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2024,12]]}},"alternative-id":["10.1111\/jre.13280"],"URL":"https:\/\/doi.org\/10.1111\/jre.13280","archive":["Portico"],"relation":{},"ISSN":["0022-3484","1600-0765"],"issn-type":[{"value":"0022-3484","type":"print"},{"value":"1600-0765","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,5,6]]},"assertion":[{"value":"2024-02-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-04-11","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-05-06","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}