{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T10:51:10Z","timestamp":1788000670376,"version":"build-2784847793"},"reference-count":52,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,5,20]],"date-time":"2024-05-20T00:00:00Z","timestamp":1716163200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Periodontal Research"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:label\/>\n                    <jats:p>\n                      The aim of this systematic review (SR) was to assess whether tooth mobility (TM) increases the risk of tooth extraction\/loss. The protocol was registered in PROSPERO database (CRD42023485425). The focused PECO questions were as follows: (1) \u201cIn patients with periodontitis, undergoing periodontal treatment, are teeth affected by mobility at higher risk of being extracted\/lost compared to non\u2010mobile teeth, with a minimum follow\u2010up of 10\u2009years?\u201d and (2) \u201cIn these patients, does varying degrees of tooth mobility increase the risk of tooth extraction\/loss, with a minimum follow\u2010up of 10\u2009years?\u201d. Results were reported according to PRISMA statement. Electronic and manual searches were conducted to identify longitudinal studies. The different assessments of tooth mobility were pooled into three groups: TM0: Undetectable tooth mobility, TM1: Horizontal\/Mesio\u2010distal mobility \u22641\u2009mm, TM2: Horizontal\/Mesio\u2010distal mobility &gt;1\u2009mm or vertical tooth mobility. Tooth loss was the primary outcome. Various meta\u2010analyses were conducted, including subgroup analyses considering different follow\u2010up lengths and the timing of TM assessment, along with sensitivity analyses. A trial sequential analysis was also performed. Eleven studies were included (1883 patients). The mean follow\u2010up range was 10\u201325\u2009years. The weighted total of included teeth, based on the sample size, was 18\u2009918, with a total of 1604 (8.47%) extracted\/lost teeth. The overall rate of tooth extraction\/loss increased with increasing mobility: TM0 was associated with a 5.85% rate (866\/14822), TM1 with the 11.8% (384\/3255), TM2 with the 40.3% (339\/841). Mobile teeth (TM1\/TM2) were at an increased risk for tooth extraction\/loss, compared to TM0 (HR: 2.85; [95% CI 1.88\u20134.32];\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.00001). TM1 had a higher risk than TM0 (HR: 1.96; [95% CI 1.09\u20133.53];\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.00001). TM2 had a higher risk than TM1 (HR: 2.85; [95% CI 2.19\u20133.70];\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.00001) and TM0 (HR: 7.12; [95% CI 3.27\u201315.51];\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.00001). The results of the tests for subgroup differences were not significant. Sensitivity meta\u2010analyses yielded consistent results with other meta\u2010analyses. Within the limits of the quality of the studies included in the meta\u2010analyses, mobile teeth were at higher risk of being extracted\/lost in the long\u2010term and higher degrees of TM significantly influenced clinicians\u2018 decision to extract a tooth. However, most teeth can be retained in the long\u2010term and thus TM should not be considered a reason for extraction or a risk factor for tooth loss, regardless of the degree of TM.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jre.13286","type":"journal-article","created":{"date-parts":[[2024,5,20]],"date-time":"2024-05-20T04:23:26Z","timestamp":1716179006000},"page":"1047-1061","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Influence of mobility on the long\u2010term risk of tooth extraction\/loss in periodontitis patients. A systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6995-6276","authenticated-orcid":false,"given":"Matteo","family":"Peditto","sequence":"first","affiliation":[{"name":"Department of Biomedical and Dental Sciences, Morphological and Functional Images University of Messina  Messina Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9928-4100","authenticated-orcid":false,"given":"Cosimo","family":"Rupe","sequence":"additional","affiliation":[{"name":"Research Unit in Periodontology and Periodontal Medicine\u2013Department of Clinical and Experimental Medicine University of Florence  Firenze Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giorgia","family":"Gambino","sequence":"additional","affiliation":[{"name":"Department of Biomedical and Dental Sciences, Morphological and Functional Images University of Messina  Messina Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Di Martino","sequence":"additional","affiliation":[{"name":"Research Unit in Periodontology and Periodontal Medicine\u2013Department of Clinical and Experimental Medicine University of Florence  Firenze Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0524-7980","authenticated-orcid":false,"given":"Luigi","family":"Barbato","sequence":"additional","affiliation":[{"name":"Research Unit in Periodontology and Periodontal Medicine\u2013Department of Clinical and Experimental Medicine University of Florence  Firenze Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3781-1715","authenticated-orcid":false,"given":"Francesco","family":"Cairo","sequence":"additional","affiliation":[{"name":"Research Unit in Periodontology and Periodontal Medicine\u2013Department of Clinical and Experimental Medicine University of Florence  Firenze Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0941-1645","authenticated-orcid":false,"given":"Giacomo","family":"Oteri","sequence":"additional","affiliation":[{"name":"Department of Biomedical and Dental Sciences, Morphological and Functional Images University of Messina  Messina Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3391-6536","authenticated-orcid":false,"given":"Raffaele","family":"Cavalcanti","sequence":"additional","affiliation":[{"name":"Private Practice Bari  Bari Italy"},{"name":"Department of General Surgery and Surgical\u2010Medical Specialties University of Catania  Catania 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