{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T03:39:42Z","timestamp":1791085182910,"version":"4.1.0"},"reference-count":48,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,6,9]],"date-time":"2024-06-09T00:00:00Z","timestamp":1717891200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Periodontal Research"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To compare the outcomes of therapy using recombinant human fibroblast growth factor (rhFGF)\u20102 combined with autologous bone grafting (ABG) therapy with those of rhFGF\u20102 alone and ABG alone in the treatment of periodontal intraosseous defects.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Periodontal intraosseous defects were randomized to receive rhFGF\u20102 therapy + ABG, rhFGF\u20102 therapy alone, or ABG alone. Periodontal examination and periapical radiography were performed preoperatively and at 3, 6, and 12\u2009months postoperatively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      At the 12\u2009months follow\u2010up, all three groups showed significant improvement in the clinical attachment level (CAL): 5.6\u2009\u00b1\u20091.6, 5.8\u2009\u00b1\u20091.7, and 5.2\u2009\u00b1\u20091.6\u2009mm in the rhFGF\u20102\u2009+\u2009ABG, rhFGF\u20102 alone, and ABG alone groups, respectively, with no significant inter\u2010group differences (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.05). rhFGF\u20102 therapy (alone or in combination) resulted in greater bone defect filling (BDF) (2.3\u2009\u00b1\u20091.2\u2009mm and 2.6\u2009\u00b1\u20091.9\u2009mm, respectively) than ABG therapy alone (1.2\u2009\u00b1\u20091.2\u2009mm). Gingival recession was lesser in the ABG alone (1.2\u2009\u00b1\u20091.1\u2009mm) and rhFGF\u20102\u2009+\u2009ABG groups (1.4\u2009\u00b1\u20090.8\u2009mm) than in the rhFGF\u20102 alone group (2.2\u2009\u00b1\u20091.2\u2009mm).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The results of this study showed that at 12\u2009months postoperatively, all treatments resulted in statistically significant clinical improvements compared to the baseline. From these results, it can be concluded that rhFGF\u20102 promotes hard tissue regeneration in intraosseous defects.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jre.13310","type":"journal-article","created":{"date-parts":[[2024,6,9]],"date-time":"2024-06-09T21:58:23Z","timestamp":1717970303000},"page":"1162-1174","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Recombinant human fibroblast growth factor and autogenous bone for periodontal regeneration: Alone or in combination? A randomized clinical trial"],"prefix":"10.1111","volume":"59","author":[{"given":"Kosuke","family":"Kojima","sequence":"first","affiliation":[{"name":"Department of Implantology and Periodontology, Graduate School of Dentistry Kanagawa Dental University  Yokohama Kanagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3801-6353","authenticated-orcid":false,"given":"Yohei","family":"Kamata","sequence":"additional","affiliation":[{"name":"Department of Implantology and Periodontology, Graduate School of Dentistry Kanagawa Dental University  Yokohama Kanagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoko","family":"Shimizu","sequence":"additional","affiliation":[{"name":"Department of Implantology and Periodontology, Graduate School of Dentistry Kanagawa Dental University  Yokohama Kanagawa 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