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Multivariable logistic regression was used to examine the association of sex hormones (exposure) with history of tooth loss (outcome), stratified by sex.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among post\u2010menopausal women, higher free testosterone (per 1SD) was associated with a greater prevalence of tooth loss [OR 1.49 (95% CI, 1.08\u20132.05)], whereas higher sex hormone binding globulin (SHBG) was associated with a lower prevalence of tooth loss [OR 0.74 (0.58\u20130.94)], after adjustment for cardiometabolic risk factors and reproductive factors. In men, higher free testosterone and lower SHBG were associated with a lower prevalent probability of tooth loss in unadjusted analysis, but these associations lost significance after covariate adjustment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>A higher androgenic sex hormone profile in post\u2010menopausal women (i.e., increased free testosterone, lower SHBG) was associated with an increased prevalence of tooth loss, after adjusting cardiometabolic risk factors. No such association was found in men. These findings suggest that sex hormones may influence or serve as a marker for periodontal health.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jre.13312","type":"journal-article","created":{"date-parts":[[2024,6,19]],"date-time":"2024-06-19T11:24:06Z","timestamp":1718796246000},"page":"166-176","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Association of endogenous sex hormone levels with tooth loss due to periodontitis in men and post\u2010menopausal women: The\u00a0multi\u2010ethnic study of atherosclerosis"],"prefix":"10.1111","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0601-3449","authenticated-orcid":false,"given":"Maria","family":"Doughan","sequence":"first","affiliation":[{"name":"School of Dentistry University of Maryland  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omar","family":"Chehab","sequence":"additional","affiliation":[{"name":"Division of Cardiology Johns Hopkins University School of Medicine  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bassel","family":"Doughan","sequence":"additional","affiliation":[{"name":"Faculty of Dental Surgery C\u00f4te d'Azur University  Nice France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joao A. 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