{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T22:36:44Z","timestamp":1788561404644,"version":"build-2803163510"},"reference-count":59,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,6,20]],"date-time":"2024-06-20T00:00:00Z","timestamp":1718841600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Periodontal Research"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To assess the impact of non\u2010surgical periodontitis treatment over conventional dermatological treatment on the severity and extent of psoriasis in patients affected by comorbid psoriasis and periodontitis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Seventy\u2010four patients affected by both psoriasis and Stages I\u2013IV periodontitis were randomized to receive either Steps 1\u20132 (non\u2010surgical) of periodontal therapy (test group;\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200937) or no treatment (control group;\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200937). The two groups were balanced in terms of psoriasis medications, with the majority of the included patients undergoing biologics (74.0%) as monotherapy, while minor proportions were under systemic medications (13.7%) or none\/topical\/phototherapy (12.3%). The psoriasis area severity index (PASI) was regarded as the primary outcome. The Body Surface Area (BSA) and the Dermatology Life Quality Index (DLQI) were additionally considered as dermatological outcomes. Probing pocket depth, recession depth, clinical attachment level, periodontal inflamed surface area, and full\u2010mouth plaque and bleeding scores were also measured. [Correction added on July 5, 2024, after first online publication: The preceding sentence has been revised].\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Periodontal therapy in the test group led to statistically significant lower PASI scores at 10\u2009weeks (mean\u2009=\u20093.15; standard deviation [SD]\u2009=\u20093.78) compared to the control group (mean\u2009=\u20097.11; SD\u2009=\u20096.09) (mean difference [MD]\u2009=\u2009\u20104.0; 95% confidence interval [CI]: \u22126.3, \u22121.6;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.001). The test group also showed improvements in BSA (MD\u2009=\u2009\u22124.3) and periodontal parameters compared to the control group. DLQI only showed a non\u2010statistically significant tendency (MD\u2009=\u2009\u22122.0).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Steps 1\u20132 of periodontal therapy showed an additional effect over conventional dermatological treatment in reducing the severity and extent of psoriasis (\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/clinicaltrials.gov\">Clinicaltrials.gov<\/jats:ext-link>\n                      : NCT05311501).\n                    <\/jats:p>\n                  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