{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T19:44:58Z","timestamp":1791575098278,"version":"4.3.4"},"reference-count":46,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,7,4]],"date-time":"2024-07-04T00:00:00Z","timestamp":1720051200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81991500"],"award-info":[{"award-number":["81991500"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81991503"],"award-info":[{"award-number":["81991503"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Periodontal Research"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To evaluate whether the ribosome\u2010crosslinked collagen membrane (RCCM) is non\u2010inferior to the natural collagen membrane (NCM) used in regeneration surgery in terms of clinical attachment level (CAL) gain at 6\u2009months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Eighty patients diagnosed as generalized periodontitis presenting with isolated infrabony defect (\u22654\u2009mm deep) were enrolled and randomized to receive regenerative surgery, either with NCM or RCCM, both combined with deproteinized bovine bone mineral (DBBM). CAL, pocket probing depth (PPD), and gingival recession (GR) were recorded at baseline, 3, and 6\u2009months postoperatively. Periapical radiographs were taken at baseline, immediately, and 6\u2009months after surgery. Early wound healing index (EHI) and patients' responses were recorded at 2\u2009weeks postoperatively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At 6\u2009months post\u2010surgery, the mean CAL gain was 3.1\u2009\u00b1\u20091.5\u2009mm in the NCM group and 2.9\u2009\u00b1\u20091.5\u2009mm in the RCCM group, while the mean PPD was 4.3\u2009\u00b1\u20091.1\u2009mm in the NCM group and 4.2\u2009\u00b1\u20091.0\u2009mm in the RCCM group. Both groups demonstrated a statistically significant improvement from the baseline (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.01). RCCM was non\u2010inferior to NCM concerning the primary outcome (CAL gain at 6\u2009months). The GR at 6\u2009months postoperatively was 1.3\u2009\u00b1\u20091.2 and 1.2\u2009\u00b1\u20091.1\u2009mm, which showed no difference compared with baseline. At 6\u2009months follow\u2010up, the radiographic linear bone fill (RLBF) was 6.5\u2009\u00b1\u20092.8 and 5.5\u2009\u00b1\u20092.6\u2009mm (<jats:italic>p<\/jats:italic>\u2009&gt;\u2009.05), while the bone fill percentage (BF%) was 102.3\u2009\u00b1\u200953.5% and 92.3\u2009\u00b1\u200940.1% (<jats:italic>p<\/jats:italic>\u2009&gt;\u2009.05), in the NCM and RCCM groups, respectively. There was no significant difference in EHI and postoperative responses between two groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>RCCM + DBBM resulted in no\u2010inferior clinical and radiographic outcomes to NCM\u2009+\u2009DBBM for the treatment of isolated infrabony defect in 6\u2009months.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jre.13321","type":"journal-article","created":{"date-parts":[[2024,7,4]],"date-time":"2024-07-04T09:39:50Z","timestamp":1720085990000},"page":"154-165","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Native vs. ribosome\u2010crosslinked collagen membranes for periodontal regeneration: A randomized clinical trial"],"prefix":"10.1111","volume":"60","author":[{"given":"Yiwei","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Periodontology, Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine  Shanghai 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