{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T11:51:41Z","timestamp":1789041101809,"version":"build-2803163510"},"reference-count":71,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,9,29]],"date-time":"2024-09-29T00:00:00Z","timestamp":1727568000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,9,29]],"date-time":"2024-09-29T00:00:00Z","timestamp":1727568000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Periodontal Research"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The aim of the present systematic review of the literature and meta\u2010analysis was to evaluate the efficacy of different protocols of NSPT without any adjunctive therapy in subjects with type 2 diabetes, by considering clinical and patient\u2010centered outcomes. For the purposes of the study randomized controlled clinical trials with more than 3\u2010month follow\u2010up were searched in MEDLINE, EMBASE, and Cochrane Central. Then the articles were screened for inclusion and considered based on the protocols adopted, the outcome measure, follow\u2010up, and the level of glycemic control. A total of 23 articles about 22 studies were included. NSPT was more effective than just oral hygiene measures\/no treatment in reducing periodontal probing depth (PPD) and clinical attachment loss (CAL) at 3 months (0.47\u2009mm [0.29\u20130.65\u2009mm] and 0.50\u2009mm [0.24\u20130.76\u2009mm], respectively) and 6 months (0.56\u2009mm [0.28\u20130.84\u2009mm] and 0.45\u2009mm [0.13\u20130.77\u2009mm], respectively for PPD and CAL) follow\u2010up (very low and low level of evidence). The meta\u2010analysis found no evidence of a difference between full\u2010mouth disinfection versus quadrant protocol clinical outcomes (very low level of evidence). One study found no evidence of a difference in periodontal clinical response between good versus poor glycemic control. Based on the results of the present research NSPT protocols could be considered more efficacious than others in terms of clinical outcomes in subjects with type 2 diabetes. Moreover, NSPT resulted in efficacious improvement of periodontal parameters and HbA1c levels compared to no treatment or oral hygiene instructions alone.<\/jats:p>","DOI":"10.1111\/jre.13327","type":"journal-article","created":{"date-parts":[[2024,9,29]],"date-time":"2024-09-29T21:50:06Z","timestamp":1727646606000},"page":"417-437","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Efficacy of different protocols of non\u2010surgical periodontal therapy in patients with type 2 diabetes: A systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"60","author":[{"given":"Stefano","family":"Corbella","sequence":"first","affiliation":[{"name":"Department of Biomedical, Surgical and Dental Sciences Universit\u00e0 degli Studi di Milano  Milan Italy"},{"name":"IRCCS Ospedale Galeazzi Sant'Ambrogio  Milan 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