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Then, these patients are candidates for adjunctive therapy associated with NPT. This study evaluates the effect of photobiomodulation (PBMT) at different wavelengths on periodontal repair in non\u2010hyperglycemic\/hyperglycemic animals.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Sixty\u2010four rats were submitted to induction of periodontitis by ligatures. Hyperglycemia was induced in half of these animals, whereas the other half remained non\u2010hyperglycemic. The animals were subdivided into 4 groups according to the PBMT protocol applied at the time of ligature removal (<jats:italic>n<\/jats:italic>\u2009=\u20098): CTR: Without PBMT; IRL: PBMT with infrared laser (808\u2009nm); RL: PBMT with red laser (660\u2009nm); and RL\u2010IRL: PBMT with red (660\u2009nm) and infrared laser (808\u2009nm). After a period of 7\u2009days, the animals were euthanized. The parameters assessed by microtomography were the bone volume relative to total tissue volume (BV\/TV%), distance from the cemento\u2010enamel junction to the top of the bone crest (CEJ\u2010CB), trabecular thickness, space between trabeculae, and number of trabeculae. Additionally, the percentage of inflammatory cells, blood vessels, and connective tissue matrix were assessed by histomorphometric analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>PBMT reduced bone loss and increased trabecular density in hyperglycemic animals (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.05), with RL being more effective in reducing linear bone loss (CEJ\u2010CB), whereas RL\u2010IRL was more effective in maintaining BV\/TV%. PBMT reduced blood vessels and increased the connective tissue component in hyperglycemic animals (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.05). RL\u2010IRL reduced inflammatory cells regardless of the systemic condition of the animal (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>PBMT (RL, RL\u2010IRL) improves the repair of periodontal tissues in hyperglycemic animals.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jre.13332","type":"journal-article","created":{"date-parts":[[2024,8,12]],"date-time":"2024-08-12T05:23:56Z","timestamp":1723440236000},"page":"246-254","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Effect of photobiomodulation with different wavelengths on periodontal repair in non\u2010hyperglycemic and hyperglycemic\u00a0rats"],"prefix":"10.1111","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1494-5016","authenticated-orcid":false,"given":"Vithor Xavier Resende","family":"de Oliveira","sequence":"first","affiliation":[{"name":"Department of 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