{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T15:59:44Z","timestamp":1792598384769,"version":"4.5.0"},"reference-count":54,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,9,26]],"date-time":"2024-09-26T00:00:00Z","timestamp":1727308800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2024,9,26]],"date-time":"2024-09-26T00:00:00Z","timestamp":1727308800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"publisher","award":["VR 2017\u201002084"],"award-info":[{"award-number":["VR 2017\u201002084"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004392","name":"Stiftelsen Patentmedelsfonden f\u00f6r Odontologisk Profylaxforskning","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004392","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010763","name":"Sveriges Ornitologiska F\u00f6rening","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010763","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Periodontal Research"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>Periodontitis and peri\u2010implantitis are chronic inflammatory diseases characterized by the destruction of supporting tissues. Despite some similarities, it is essential to understand the differences in how these diseases elicit unique host responses within the oral tissues, including the production of selected matrix metalloproteinases (MMPs) and inflammatory mediators involved in tissue remodelling. The aim of this study was to evaluate the levels of proteolytic enzymes MMP\u20101, MMP\u20102, MMP\u20103, as well as the inflammatory mediators osteopontin (OPN), pentraxin\u20103 (PTX3), and thymic stromal lymphopoietin (TSLP) in crevicular fluid samples collected from healthy, periodontitis\u2010affected, and peri\u2010implantitis sites.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Gingival crevicular fluid (GCF) and peri\u2010implant crevicular fluid (PICF) samples were collected from healthy and diseased teeth and implant sites of 163 patients. The MMP\u20101, MMP\u20102, MMP\u20103, OPN, PTX3, and TSLP levels were determined using commercially available immunoassays. A linear mixed model procedure was adopted for multilevel analyses, using biomarker levels as the outcome variable to compare two types of sites. The diagnostic accuracy of the biomarkers was evaluated by Youden's index to estimate the sensitivity, specificity and the area under curve (AUC).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The levels of MMP\u20101, MMP\u20102, MMP\u20103, OPN, and TSLP were higher at sites with periodontitis and peri\u2010implantitis compared to the levels at sites with healthy teeth and healthy implants. No significant differences were observed in the levels of the measured markers between the sites diagnosed with periodontitis and those diagnosed with peri\u2010implantitis. The highest diagnostic potential at implant sites was found for MMP\u20102 (AUC\u2009=\u20090.74) and TSLP (AUC\u2009=\u20090.72). The highest AUC (0.82) at tooth sites was found for OPN.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The findings indicate that the proteolytic enzyme MMP\u20102 and the cytokine TSLP might be potential biomarkers for both periodontitis and peri\u2010implantitis, whereas the proinflammatory cytokine OPN may serve as a biomarker for periodontitis. Further studies are required to confirm the utility of these biomarkers and explore their potential clinical applications.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jre.13338","type":"journal-article","created":{"date-parts":[[2024,9,26]],"date-time":"2024-09-26T23:03:52Z","timestamp":1727391832000},"page":"473-483","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Levels of matrix metalloproteinase\u20101 (\n                    <scp>MMP<\/scp>\n                    \u20101),\n                    <scp>MMP<\/scp>\n                    \u20102,\n                    <scp>MMP<\/scp>\n                    \u20103, osteopontin, pentraxin\u20103, and thymic stromal lymphopoietin in crevicular fluid samples from peri\u2010implantitis, periodontitis, and healthy sites"],"prefix":"10.1111","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5923-5777","authenticated-orcid":false,"given":"Leif","family":"Jansson","sequence":"first","affiliation":[{"name":"Folktandv\u00e5rden Stockholms l\u00e4n AB, Folktandv\u00e5rden Eastmaninstitutet Department of Periodontology  Stockholm Sweden"},{"name":"Department of Dental Medicine, Division of Periodontology Karolinska Institutet  Huddinge Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3655-3710","authenticated-orcid":false,"given":"Anna","family":"Lundmark","sequence":"additional","affiliation":[{"name":"Department of Dental Medicine, Division of Pediatric Dentistry Karolinska Institutet  Huddinge Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6729-3990","authenticated-orcid":false,"given":"Carolina","family":"Modin","sequence":"additional","affiliation":[{"name":"Folktandv\u00e5rden Stockholms l\u00e4n AB, Folktandv\u00e5rden Eastmaninstitutet Department of Periodontology  Stockholm Sweden"},{"name":"Department of Dental Medicine, Division of Periodontology Karolinska Institutet  Huddinge Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6481-858X","authenticated-orcid":false,"given":"Anders","family":"Gustafsson","sequence":"additional","affiliation":[{"name":"Department of Dental Medicine, Division of Periodontology Karolinska Institutet  Huddinge Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0129-8809","authenticated-orcid":false,"given":"T\u00fclay","family":"Yucel\u2010Lindberg","sequence":"additional","affiliation":[{"name":"Department of Dental Medicine, Division of Pediatric Dentistry Karolinska Institutet  Huddinge Sweden"},{"name":"Department of Microbiology, Faculty of Biochemistry, Biophysics and Biotechnology Jagiellonian University  Krakow Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,9,26]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034514552491"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(19)31146-8"},{"key":"e_1_2_10_4_1","unstructured":"Global oral health report.https:\/\/www.who.int\/team\/noncommunicable\u2010diseases\/global\u2010status\u2010report\u2010on\u2010oral\u2010health\u20102022"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri3785"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13807"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/821383"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1017\/erm.2013.8"},{"key":"e_1_2_10_9_1","first-page":"299","article-title":"Tissue destruction in periodontitis: bacteria or cytokines fault?","volume":"36","author":"Bascones A","year":"2005","journal-title":"Quintessence Int"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12490"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.1993.tb02113.x"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2013.1222"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2008.05.004"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI12980"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12954"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12334"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12335"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.0906-6713.2002.003422.x"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.13725"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23168929"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells9051076"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/jre.12957"},{"key":"e_1_2_10_23_1","first-page":"316","article-title":"Osteopontin stimulates matrix metalloproteinase expression through the nuclear factor\u2010kappaB signaling pathway in rat temporomandibular joint and condylar chondrocytes","volume":"9","author":"Ding F","year":"2017","journal-title":"Am J Transl Res"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-022-00735-y"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12079-009-0068-0"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1159\/000493219"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0757.2010.00348.x"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/jre.12483"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/JPER.17-0721"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.h5527"},{"key":"e_1_2_10_31_1","first-page":"229","article-title":"Problems and proposals for recording gingivitis and plaque","volume":"25","author":"Ainamo J","year":"1975","journal-title":"Int Dent J"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/JPER.17-0739"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23031806"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1080\/07853890600800103"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12101"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0501.2003.140204.x"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics9040214"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1999.tb07679.x"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/jopr.13270"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13643-021-01860-w"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/JPER.17-0475"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12229"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.2007.00968.x"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0023831"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni0702-605"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1111\/jre.12078"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0607305104"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2007.03.081"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-404717-4.00004-4"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1111\/jre.12915"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0152794"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12586"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2010.100526"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10266-011-0042-1"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034515608832"}],"container-title":["Journal of Periodontal Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jre.13338","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jre.13338","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jre.13338","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T11:15:16Z","timestamp":1771240516000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jre.13338"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,26]]},"references-count":54,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,5]]}},"alternative-id":["10.1111\/jre.13338"],"URL":"https:\/\/doi.org\/10.1111\/jre.13338","archive":["Portico"],"relation":{},"ISSN":["0022-3484","1600-0765"],"issn-type":[{"value":"0022-3484","type":"print"},{"value":"1600-0765","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9,26]]},"assertion":[{"value":"2023-11-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-08-05","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-09-26","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}