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Subsequently, a mouth gel containing 1% FeTcPc was topically administered to the gingival tissue of mice with periodontitis\u2010induced ligatures. Bone loss and the gene expression of <jats:italic>Tnf\u03b1<\/jats:italic>, <jats:italic>p65<\/jats:italic> (NF\u2010\u03baB), and receptor\u2010activating nuclear factor kappa B ligand (<jats:italic>Rankl<\/jats:italic>) were quantified in gingival tissue. Finally, the systemic toxicity of FeTcPc was estimated in <jats:italic>Galleria mellonella<\/jats:italic> larvae.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In an activated RAW 264.7 macrophage culture, 100\u2009\u03bcM FeTcPc reduced TNF\u2010\u03b1 release and NF\u2010\u03baB activation. Regarding experimental periodontitis, topical application of mouth gel containing 1% FeTcPc blocked alveolar bone loss. Additionally, 1% FeTcPc reduced the expression of <jats:italic>Tnf\u03b1<\/jats:italic>, <jats:italic>p65<\/jats:italic> (NF\u2010\u03baB), and <jats:italic>Rankl<\/jats:italic> in gingival tissue. Finally, administration FeTcPc at doses ranging from 1 to 1000\u2009mg\/kg did not cause acute systemic toxicity in <jats:italic>G. mellonella<\/jats:italic>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Overall, we demonstrated the potential of mouth gel containing FeTcPc as a therapeutic strategy for managing osteolytic inflammatory disorders, such as periodontitis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jre.13341","type":"journal-article","created":{"date-parts":[[2024,10,7]],"date-time":"2024-10-07T11:43:48Z","timestamp":1728301428000},"page":"373-379","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Phthalocyanine derivative attenuates <scp>TNF<\/scp>\u2010\u03b1 production in macrophage culture and prevents alveolar bone loss in experimental 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