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This randomized trial assessed the effect of clindamycin (CLN) augmented injectable platelet\u2010rich fibrin (I\u2010PRF) with modified minimally invasive surgical technique (M\u2010MIST) versus I\u2010PRF alone with M\u2010MIST on the clinical and radiographic parameters in the management of periodontal intra\u2010bony defects in patients with stage\u2010III grade B periodontitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This is a 9\u2010month parallel\u2010grouped, two arm, double\u2010blinded, randomized controlled trial (RCT) that included 28 patients (<jats:italic>n<\/jats:italic>\u2009=\u200928) with stage\u2010III grade B periodontitis, who were allocated randomly to test\u2010 (CLN\/I\u2010PRF\u2009+\u2009M\u2010MIST, 50\u2009\u03bcL of CLN per 1\u2009mL of I\u2010PRF; <jats:italic>n<\/jats:italic>\u2009=\u200914) or control\u2010group (I\u2010PRF\u2009+\u2009M\u2010MIST; <jats:italic>n<\/jats:italic>\u2009=\u200914). Clinical attachment level (CAL; primary outcome), probing depth (PD), gingival margin level (GML), plaque index (PI), and gingival index (GI) were recorded at baseline, 3, 6, and 9\u2009months, whereas radiographic parameters radiographic linear defect depth (RLDD), and radiographic defect area (RDA) were recorded at baseline, 6, and 9\u2009months. The CLN release kinetics from the I\u2010PRF were further characterized.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Compared to baseline, both groups independently demonstrated significant improvements in CAL, PD, GML, GI, PI, RLDD and BDA at 3, 6 and 9\u2009months (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.05). A significant reduction in CAL measurements was noticeable in the CLN\/I\u2010PRF\u2009+\u2009M\u2010MIST and I\u2010PRF\u2009+\u2009M\u2010MIST group independently over time (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.05). CLN\/I\u2010PRF\u2009+\u2009M\u2010MIST showed significantly lower CAL than PRF\u2009+\u2009M\u2010MIST group at baseline, after three as well as 9\u2009months (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.05). Intergroup comparisons at 9\u2009months demonstrated that CAL\u2010gain was non\u2010significant between groups (<jats:italic>p<\/jats:italic>\u2009&gt;\u2009.05), GI significantly lower in CLN\/I\u2010PRF\u2009+\u2009M\u2010MIST, whereas PD\u2010reduction significantly higher I\u2010PRF\u2009+\u2009M\u2010MIST group (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.05). CLN was steadily released for the I\u2010PRF for up to 48\u2009h, with a peak concentration at 24\u2009h, which then gradually declined till the seventh day.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>I\u2010PRF with M\u2010MIST provided significant clinical and radiographic improvement up to 9\u2009months postoperatively in stage\u2010III grade B periodontitis. CLN, at the applied concentration and release duration, does not appear to further positively impact these observed I\u2010PRF effects.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jre.13344","type":"journal-article","created":{"date-parts":[[2024,9,3]],"date-time":"2024-09-03T07:50:51Z","timestamp":1725349851000},"page":"326-339","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Modified minimally invasive surgical technique with clindamycin\u2010augmented or non\u2010augmented platelet\u2010rich fibrin in periodontal regeneration: A randomized clinical trial"],"prefix":"10.1111","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-1433-2523","authenticated-orcid":false,"given":"Sarah","family":"Yusri","sequence":"first","affiliation":[{"name":"Oral Medicine and Periodontology Department, Faculty of Dentistry Cairo\u00a0University  Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1818-0321","authenticated-orcid":false,"given":"Weam","family":"Elbattawy","sequence":"additional","affiliation":[{"name":"Oral Medicine and Periodontology Department, Faculty of Dentistry Cairo\u00a0University  Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-3250-8436","authenticated-orcid":false,"given":"Salma","family":"Zaaya","sequence":"additional","affiliation":[{"name":"Oral Medicine and Periodontology Department, Faculty of Dentistry Cairo\u00a0University  Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maha","family":"Mokhtar","sequence":"additional","affiliation":[{"name":"Proteomics and Metabolomics Research Program, Basic Research Department Children's Cancer Hospital  Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asmaa","family":"Ramzy","sequence":"additional","affiliation":[{"name":"Proteomics and Metabolomics Research Program, Basic Research Department Children's Cancer Hospital  Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6261-3609","authenticated-orcid":false,"given":"Karim M.","family":"Fawzy El\u2010Sayed","sequence":"additional","affiliation":[{"name":"Oral Medicine and Periodontology Department, Faculty of Dentistry Cairo\u00a0University  Cairo Egypt"},{"name":"Clinic for Conservative Dentistry and Periodontology, School of Dental Medicine Christian Albrechts University  Kiel Germany"},{"name":"Stem Cells and Tissue Engineering Unit, Faculty of Dentistry Cairo University  Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,9,3]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13230"},{"issue":"2","key":"e_1_2_13_3_1","first-page":"251","article-title":"Nonsurgical periodontal treatment","volume":"9","author":"Aimetti M","year":"2014","journal-title":"Int J Esthet Dent"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0757.2006.00157.x"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12156"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13290"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13721"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2007.01144.x"},{"issue":"3","key":"e_1_2_13_9_1","first-page":"257","article-title":"Minimally invasive surgical technique and enamel matrix derivative in intrabony defects: 2. 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