{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:14:11Z","timestamp":1787015651369,"version":"build-2736575974"},"reference-count":44,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,9,25]],"date-time":"2024-09-25T00:00:00Z","timestamp":1727222400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Periodontal Research"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>This study aimed to assess the variability and treatment effect heterogeneity in response to non\u2010surgical periodontal therapy (NSPT).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Data from randomized controlled trials included in two recent systematic reviews on the effect of NSPT on mean clinical attachment loss (CAL), mean probing pocket depth (PPD), percentage of sites with bleeding on probing (%BOP), PPD \u22643\u2009mm (%PD \u22643\u2009mm), and C\u2010reactive protein levels (CRP) at 3\u201312\u2010month follow\u2010up among adults with systemic diseases or conditions were used. In these trials, the control arms received no treatment, hygiene advice, or supragingival scaling. The Bayesian meta\u2010regression models were utilized to assess the variability ratios between NSPT and control groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Data from 36 trials on mean PPD, 32 trials on mean CAL, eight trials on %PD \u22643\u2009mm, 31 trials on %BOP and 19 trials on CRP were used. Variability in mean CAL and CRP was approximately 10% higher in the NSPT arms than in the control arms, hinting that there may be room for treatment effect heterogeneity. Instead, variability in mean PPD, %BOP, and %PD \u22643\u2009mm was lower in the NSPT arms than in the control arms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Potential treatment effect heterogeneity in response to NSPT was observed for CRP and mean CAL. However, substantial measurement error in CAL and natural variation in CRP may contribute to these findings. Conversely, treatment effect heterogeneity appears less pronounced for mean PPD, %BOP, and %PD\u2009\u22643\u2009mm, potentially due to greater treatment effects in patients with more severe periodontitis and reduced measurement error in these parameters.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jre.13347","type":"journal-article","created":{"date-parts":[[2024,9,25]],"date-time":"2024-09-25T06:51:16Z","timestamp":1727247076000},"page":"315-325","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Do all individuals benefit equally from non\u2010surgical periodontal therapy? Secondary analyses of systematic review data"],"prefix":"10.1111","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9258-9355","authenticated-orcid":false,"given":"Eero","family":"Raittio","sequence":"first","affiliation":[{"name":"Department of Dentistry and Oral Health Aarhus University  Aarhus Denmark"},{"name":"Institute of Dentistry University of Eastern Finland  Kuopio Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8053-4517","authenticated-orcid":false,"given":"Fabio R. M.","family":"Leite","sequence":"additional","affiliation":[{"name":"National Dental Research Institute Singapore National Dental Centre Singapore  Singapore City Singapore"},{"name":"Oral Health Academic Clinical Programme Duke\u2010NUS Medical School  Singapore City Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2503-260X","authenticated-orcid":false,"given":"Vanessa","family":"Machado","sequence":"additional","affiliation":[{"name":"Egas Moniz Center for Interdisciplinary Research Egas Moniz School of Health and Science  Caparica Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1019-8263","authenticated-orcid":false,"given":"Jo\u00e3o","family":"Botelho","sequence":"additional","affiliation":[{"name":"Egas Moniz Center for Interdisciplinary Research Egas Moniz School of Health and Science  Caparica Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4288-6300","authenticated-orcid":false,"given":"Gustavo G.","family":"Nascimento","sequence":"additional","affiliation":[{"name":"National Dental Research Institute Singapore National Dental Centre Singapore  Singapore City Singapore"},{"name":"Oral Health Academic Clinical Programme Duke\u2010NUS Medical School  Singapore City Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,9,25]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-023-05392-6"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13709"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13245"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2017.12.001"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13290"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-022-04469-y"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.6739"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1986.tb01487.x"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/eos.12670"},{"issue":"1","key":"e_1_2_9_11_1","first-page":"S50","article-title":"Biologically informed stratification of periodontal disease holds the key to achieving precision oral health","volume":"91","author":"Divaris K","year":"2020","journal-title":"J Periodontol"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/JPER.18-0006"},{"key":"e_1_2_9_13_1","first-page":"2184","article-title":"Using group data to treat individuals: understanding heterogeneous treatment effects in the age of precision medicine and patient\u2010centred evidence","volume":"45","author":"Dahabreh IJ","year":"2016","journal-title":"Int J Epidemiol"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research.13490.1"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2019.1530"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1037\/cps0000079"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0241497"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/jrsm.1423"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.janxdis.2022.102611"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1992.63.2.118"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/JPER.23-0285"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13109"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1983.tb01266.x"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13207"},{"key":"e_1_2_9_25_1","first-page":"CD012568","article-title":"Adjunctive systemic antimicrobials for the non\u2010surgical treatment of periodontitis","volume":"11","author":"Khattri S","year":"2020","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.4103\/ccd.ccd_514_21"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13037"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1177\/00220345241237448"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/cdoe.12942"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13384"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.1996.tb00500.x"},{"issue":"39","key":"e_1_2_9_32_1","first-page":"30","article-title":"Clinical parameters: biological validity and clinical utility","volume":"2005","author":"Mombelli A","year":"2000","journal-title":"Periodontol"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1987.tb01548.x"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/idj.12218"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.1997.tb00565.x"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13288"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/JPER.22-0231"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinternmed.2012.3712"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0060759"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1080\/10503307.2023.2215396"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1111\/rssa.12614"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/d41586-018-07535-2"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1186\/1745-6215-8-31"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.2519\/jospt.2023.11853"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1111\/cdoe.12856"}],"container-title":["Journal of Periodontal Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jre.13347","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,5]],"date-time":"2025-06-05T10:34:20Z","timestamp":1749119660000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jre.13347"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,25]]},"references-count":44,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,4]]}},"alternative-id":["10.1111\/jre.13347"],"URL":"https:\/\/doi.org\/10.1111\/jre.13347","archive":["Portico"],"relation":{},"ISSN":["0022-3484","1600-0765"],"issn-type":[{"value":"0022-3484","type":"print"},{"value":"1600-0765","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9,25]]},"assertion":[{"value":"2024-06-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-08-27","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-09-25","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}