{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T21:01:33Z","timestamp":1792789293064,"version":"4.5.0"},"reference-count":62,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,10,28]],"date-time":"2024-10-28T00:00:00Z","timestamp":1730073600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,10,28]],"date-time":"2024-10-28T00:00:00Z","timestamp":1730073600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Periodontal Research"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>This systematic review investigates the effectiveness of implant therapy in patients with and without a history of periodontitis in terms of implant loss, peri\u2010implant marginal bone loss (MBL), and occurrence of peri\u2010implant diseases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The protocol of the present meta\u2010analysis was registered on PROSPERO (CRD42021264980). An electronic search was conducted up to April 2024. All prospective cohort studies reporting implant loss, MBL, and occurrence of peri\u2010implant diseases in both patients with a history of periodontitis (HP) and patients with no history of periodontitis (NHP) after at least 36\u2010month follow\u2010up were included. The risk of bias was evaluated using the Newcastle\u2010Ottawa Scale and the quality of the evidence was also assessed. A meta\u2010analysis was performed on the selected outcomes at the available follow\u2010up time points. Subgroup analyses were conducted based on follow\u2010up time, rate of progression and severity of periodontitis, and implant surface characteristics. Publication bias was evaluated using the Funnel plot and Egger's test.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      From 13\u2009761 initial records, 14 studies (17 articles) were finally included. Eight studies had a low risk of bias level, and six had a medium risk of bias level. Meta\u2010analysis showed that HP patients had a significantly greater risk for implant loss (HR: 1.75; 95% CI: 1.28\u20132.40;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.0005;\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u20090%), MBL (MD: 0.41\u2009mm; 95% CI 0.19, 0.63;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.0002;\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u200954%), and peri\u2010implantitis (3.24; 95% CI: 1.58\u20136.64;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001;\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u200957%) compared to NHP, whereas no significant intergroup difference for peri\u2010implant mucositis was found. Subgroup analyses revealed a particularly greater risk for implant loss for HP patients over a \u2265\u200910\u2010year follow\u2010up (HR: 2.02; 95% CI: 1.06\u20133.85;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.03;\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u20090%) and for patients with a history of grade C (formerly aggressive) periodontitis (HR: 6.16; 95% CI: 2.53\u201315.01;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001;\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u20090%). A greater risk for implant loss for stages III\u2013IV (severe) periodontitis, and implants with rough surfaces was also found.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Within the limits of heterogeneous case definitions and methods of assessment, a history of periodontitis has been proved to significantly increase the risk for implant loss, particularly at long follow\u2010up (\u2265\u200910\u2009years) and in case of rapidly progressive forms (grade C), and for MBL and peri\u2010implantitis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jre.13351","type":"journal-article","created":{"date-parts":[[2024,10,28]],"date-time":"2024-10-28T12:38:16Z","timestamp":1730119096000},"page":"524-543","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Effectiveness of Implant Therapy in Patients With and Without a History of Periodontitis: A Systematic Review With Meta\u2010Analysis of Prospective Cohort Studies"],"prefix":"10.1111","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4605-2087","authenticated-orcid":false,"given":"Marco","family":"Annunziata","sequence":"first","affiliation":[{"name":"Multidisciplinary Department of Medical\u2010Surgical and Dental Specialties University of Campania \u201cLuigi Vanvitelli\u201d  Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9393-730X","authenticated-orcid":false,"given":"Gennaro","family":"Cecoro","sequence":"additional","affiliation":[{"name":"Multidisciplinary Department of Medical\u2010Surgical and Dental Specialties University of Campania \u201cLuigi Vanvitelli\u201d  Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0177-1301","authenticated-orcid":false,"given":"Agostino","family":"Guida","sequence":"additional","affiliation":[{"name":"U.O.C. Odontostomatologia A.O.R.N. \u201cA. Cardarelli\u201d  Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4267-6992","authenticated-orcid":false,"given":"Gaetano","family":"Isola","sequence":"additional","affiliation":[{"name":"Department of General Surgery and Surgical\u2010Medical Specialties, School of Dentistry University of Catania, AOU \u201cPoliclinico\u2010San Marco\u201d  Catania Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8726-4145","authenticated-orcid":false,"given":"Paolo","family":"Pesce","sequence":"additional","affiliation":[{"name":"Department of Surgical Sciences and Integrated Diagnostics (DISC) Genova University  Genoa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3602-2773","authenticated-orcid":false,"given":"Roberto","family":"Sorrentino","sequence":"additional","affiliation":[{"name":"Department of Neurosciences, Reproductive and Odontostomatological Sciences, Division of Prosthodontics, Scientific Unit of Digital Dentistry University \u201cFederico II\u201d of Naples  Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7144-0984","authenticated-orcid":false,"given":"Massimo","family":"del Fabbro","sequence":"additional","affiliation":[{"name":"Department of Biomedical, Surgical and Dental Sciences University of Milan  Milan Italy"},{"name":"Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1345-8518","authenticated-orcid":false,"given":"Luigi","family":"Guida","sequence":"additional","affiliation":[{"name":"Multidisciplinary Department of Medical\u2010Surgical and Dental Specialties University of Campania \u201cLuigi Vanvitelli\u201d  Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,10,28]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/jre.13337"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2012.02557.x"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijom.2014.10.023"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12334"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12903-022-02493-8"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13823"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdent.2017.04.011"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/JPER.17-0719"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/jre.12562"},{"issue":"84","key":"e_1_2_11_11_1","first-page":"145","article-title":"Breaking the Wave of Peri\u2010Implantitis","volume":"2020","author":"Fu J.\u2010H.","year":"2000","journal-title":"Periodontology"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12954"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12096"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdent.2024.105065"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.12319"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.5037\/jomr.2016.7303"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.11607\/jomi.3544"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/ID.0000000000000156"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2006.01347.x"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13481"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/cid.13330"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n71"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2018.07.015"},{"key":"e_1_2_11_24_1","volume-title":"The Newcastle\u2010Ottawa Scale (NOS) for Assessing the Quality of Nonrandomised Studies in Meta\u2010Analyses","author":"Wells G.","year":"2014"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2020.37341"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1186\/1745-6215-8-16"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.1186"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/cid.12761"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2009.01750.x"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.12642"},{"key":"e_1_2_11_31_1","first-page":"45","article-title":"Outcome of Dental Implants in Partially Edentulous Patients With and Without a History of Periodontitis: A 5\u2010Year Interim Analysis of a Cohort Study","volume":"1","author":"Gatti C.","year":"2008","journal-title":"European Journal of Oral Implantology"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0501.000.00934.x"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2011.01745.x"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2007.070201"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2005.76.4.534"},{"key":"e_1_2_11_36_1","first-page":"331","article-title":"Implants in Regenerated Bone in Patients Treated for Generalized Aggressive Periodontitis: A Prospective Longitudinal Study","volume":"25","author":"Mengel R.","year":"2005","journal-title":"International Journal of Periodontics and Restorative Dentistry"},{"key":"e_1_2_11_37_1","first-page":"231","article-title":"A Telescopic Crown Concept for the Restoration of Partially Edentulous Patients With Aggressive Generalized Periodontitis: A 3\u2010Year Prospective Longitudinal Study","volume":"27","author":"Mengel R.","year":"2007","journal-title":"International Journal of Periodontics and Restorative Dentistry"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.12227"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13716"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2009.01886.x"},{"key":"e_1_2_11_41_1","first-page":"211","article-title":"Longitudinal Assessment of Peri\u2010Implant Diseases in Patients With and Without History of Periodontitis: A 20\u2010Year Follow\u2010Up Study","volume":"16","author":"Roccuzzo A.","year":"2023","journal-title":"International Journal of Oral Implantology"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2011.02309.x"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.12941"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2012.110603"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1002\/JPER.17-0739"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1999.70.11.1322"},{"key":"e_1_2_11_47_1","volume-title":"Proceedings of the World Workshop in Clinical Periodontics","author":"American Academy of Periodontology","year":"1989"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.1902\/annals.1997.2.1.343"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0757.1998.tb00124.x"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0501.2000.011S1146.x"},{"key":"e_1_2_11_51_1","first-page":"365","volume-title":"Proceedings of the First European Workshop on Periodontology, Thurgau, Switzerland, 1\u20104 February 1993","author":"Albrektsson T.","year":"1994"},{"key":"e_1_2_11_52_1","first-page":"536","article-title":"Oral Implant Surfaces: Part 1\u2014Review Focusing on Topographic and Chemical Properties of Different Surfaces and In\u00a0Vivo Responses to Them","volume":"17","author":"Albrektsson T.","year":"2004","journal-title":"International Journal of Prosthodontics"},{"key":"e_1_2_11_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdent.2014.09.013"},{"issue":"81","key":"e_1_2_11_54_1","first-page":"209","article-title":"Patient Compliance as a Risk Factor for the Outcome of Implant Treatment","volume":"2019","author":"Cortellini S.","year":"2000","journal-title":"Periodontology"},{"key":"e_1_2_11_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jebdp.2015.10.003"},{"key":"e_1_2_11_56_1","doi-asserted-by":"publisher","DOI":"10.1002\/JPER.17-0721"},{"key":"e_1_2_11_57_1","doi-asserted-by":"publisher","DOI":"10.1902\/annals.1999.4.1.1"},{"key":"e_1_2_11_58_1","doi-asserted-by":"publisher","DOI":"10.1002\/JPER.21-0012"},{"key":"e_1_2_11_59_1","doi-asserted-by":"publisher","DOI":"10.11607\/jomi.7714"},{"key":"e_1_2_11_60_1","doi-asserted-by":"publisher","DOI":"10.1002\/JPER.23-0048"},{"key":"e_1_2_11_61_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13790"},{"key":"e_1_2_11_62_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm12175547"},{"key":"e_1_2_11_63_1","doi-asserted-by":"publisher","DOI":"10.1037\/0033-2909.86.3.638"}],"container-title":["Journal of Periodontal Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jre.13351","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jre.13351","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jre.13351","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,8]],"date-time":"2026-02-08T09:59:06Z","timestamp":1770544746000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jre.13351"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,28]]},"references-count":62,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,6]]}},"alternative-id":["10.1111\/jre.13351"],"URL":"https:\/\/doi.org\/10.1111\/jre.13351","archive":["Portico"],"relation":{},"ISSN":["0022-3484","1600-0765"],"issn-type":[{"value":"0022-3484","type":"print"},{"value":"1600-0765","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,28]]},"assertion":[{"value":"2024-06-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-09-16","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-10-28","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}