{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T11:33:44Z","timestamp":1774956824917,"version":"3.50.1"},"reference-count":29,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,10,22]],"date-time":"2024-10-22T00:00:00Z","timestamp":1729555200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Periodontal Research"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To assess the correlation between micro\u2010computed tomography (micro\u2010CT) and linear morphometric measurements in terms of mandibular bone levels in a modified experimental periodontitis model in rodents to study the mechanisms of association between periodontal destruction and neuroinflammation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The proposed in\u00a0vivo experimental periodontitis model involves the administration of oral rinses with <jats:italic>Porphyromonas gingivalis<\/jats:italic> and <jats:italic>Fusobacterium nucleatum,<\/jats:italic> four times per week during 4, 8 or 12\u2009weeks, in 24 male Wistar Hannover rats (180\u2009g, 5\u2009weeks old). After euthanasia, hemi\u2010mandibles were collected. One hemi\u2010mandible was analysed using morphometry, while the other was assessed with micro\u2010CT. Linear measurements were taken at the buccal aspect and furcation level for both techniques, and volumetric measurements were also obtained with micro\u2010CT. Passing\u2013Bablok regression analysis was used to compare the results of both techniques, with morphometric measurements serving as the reference. Moreover, Lin's Concordance correlation coefficient was calculated to assess the level of agreement. Periodontal clinical variables with neuroinflammatory parameters from the frontal cortex were used to evaluate the association between the resulting condition and neuroinflammation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty\u2010one out of the initial 24 rats were analysed. The micro\u2010CT linear measurements demonstrated high concordance values with the linear morphometric measurements at the buccal surfaces of the roots in molars (<jats:italic>r<\/jats:italic>\u2009=\u20090.714) but not at the furcation area (<jats:italic>r<\/jats:italic>\u2009=\u20090.052). At 12\u2009weeks, there was a significant impact on neuroinflammation with significant decreases in iNOS levels and p\u2010mTOR levels at 4 and 8\u2009weeks.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The proposed in\u00a0vivo experimental periodontitis model demonstrated a high degree of correlation between morphometric and micro\u2010CT measurements in buccal areas but not at the furcation level. Concomitantly, there was a significant temporary modulation of the neuroinflammatory response.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jre.13354","type":"journal-article","created":{"date-parts":[[2024,10,22]],"date-time":"2024-10-22T17:44:13Z","timestamp":1729619053000},"page":"361-372","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Comparison of Micro\u2010<scp>CT<\/scp> and Morphometric Outcomes in a Modified Experimental Rat Model of Periodontitis"],"prefix":"10.1111","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4872-8522","authenticated-orcid":false,"given":"Jaime","family":"Bueno","sequence":"first","affiliation":[{"name":"ETEP (Etiology and Therapy of Periodontal and Peri\u2010Implant Diseases) Research Group University Complutense (UCM)  Madrid 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Peri\u2010Implant Diseases) Research Group University Complutense (UCM)  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6975-3452","authenticated-orcid":false,"given":"Javier","family":"Robledo\u2010Monta\u00f1a","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, Faculty of Medicine UCM Hospital 12 de Octubre Research Institute (Imas12), Neurochemistry Research Institute, IUIN  Madrid Spain"},{"name":"Biomedical Network Research Center of Mental Health (CIBERSAM) Institute of Health Carlos III  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5199-8067","authenticated-orcid":false,"given":"Juan D.","family":"Gamonal","sequence":"additional","affiliation":[{"name":"ETEP (Etiology and Therapy of Periodontal and Peri\u2010Implant Diseases) Research Group University Complutense (UCM)  Madrid 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