{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T12:06:22Z","timestamp":1771243582213,"version":"3.50.1"},"reference-count":49,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,10,28]],"date-time":"2024-10-28T00:00:00Z","timestamp":1730073600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2024,10,28]],"date-time":"2024-10-28T00:00:00Z","timestamp":1730073600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Periodontal Research"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>This preclinical study aimed to evaluate the periodontal tissue regenerative capacities of poly (lactic acid\/caprolactone) (PLCL) bilayer membrane in one\u2010wall intrabony defects in dogs. No study has assessed the efficacy of PLCL bilayer membrane for periodontal regeneration therapy despite the fact that PLCL bilayer membrane has proved efficient for bone regeneration.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      In five beagle dogs, the bilateral mandibular second and fourth premolars were extracted 8\u2009weeks before the experimental surgery. Standardized bone defects (5\u2009mm in height and 6\u2009mm in width) were surgically created on the mesial and distal roots of the bilateral third premolars in the mandible. The test groups were set up as follows: (i) carbonate apatite (CO\n                      <jats:sub>3<\/jats:sub>\n                      Ap)\u2009+\u2009PLCL, (ii) CO\n                      <jats:sub>3<\/jats:sub>\n                      Ap, (iii) xenograft (DBBM)\u2009+\u2009collagen membrane (CM), and (iv) DBBM. The control group was left empty. Radiological, histologic and histomorphometric characteristics were compared 8\u2009weeks after surgery.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>No infectious complications were detected at any of the tested sites. The test groups exhibited a greater height and volume of the newly formed bone than the control group. They also showed a greater height of the newly formed cementum than the control group. However, the results were not statistically significant. The newly formed periodontal ligaments were inserted into newly formed bone and cementum in the test groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      The combined use of PLCL bilayer membrane and CO\n                      <jats:sub>3<\/jats:sub>\n                      Ap demonstrated comparable performance for periodontal tissue regeneration in one\u2010wall intrabony defects compared to conventional therapies.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jre.13355","type":"journal-article","created":{"date-parts":[[2024,10,28]],"date-time":"2024-10-28T07:39:52Z","timestamp":1730101192000},"page":"504-514","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Preclinical Evaluation of a Poly (Lactic Acid\/Caprolactone) Bilayer Membrane and a Carbonate Apatite for Periodontal Regeneration: A Canine One\u2010Wall Intrabony Defect Model"],"prefix":"10.1111","volume":"60","author":[{"given":"Daichi","family":"Yamaki","sequence":"first","affiliation":[{"name":"Department of Periodontology, Graduate School of Medical and Dental Science Institute of Science Tokyo 1\u20105\u201045, Yushima, Bunkyo\u2010Ku  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1066-7541","authenticated-orcid":false,"given":"Shunsuke","family":"Fukuba","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Graduate School of Medical and Dental Science Institute of Science Tokyo 1\u20105\u201045, Yushima, Bunkyo\u2010Ku  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Munehiro","family":"Okada","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Graduate School of Medical and Dental Science Institute of Science Tokyo 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