{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T15:59:44Z","timestamp":1792598384564,"version":"4.5.0"},"reference-count":52,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,1,13]],"date-time":"2025-01-13T00:00:00Z","timestamp":1736726400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,13]],"date-time":"2025-01-13T00:00:00Z","timestamp":1736726400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Periodontal Research"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>This prospective cohort study aimed to evaluate the incidence and risk\/protective factors of peri\u2010implantitis over time.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A university\u2010representative cohort was evaluated at baseline and after a mean follow\u2010up time of 3.9\u2009years. The main outcome was the incidence of peri\u2010implantitis, defined as bone loss &gt;\u20091\u2009mm between the two examinations in implants showing bleeding on probing. Putative risk\/protective factors assessed at baseline were tested through multilevel (mixed\u2010effects) logistic regression analyses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 73 patients with 322 implants were included. During the follow\u2010up period, 14 implants (4.3%) were lost in 9 patients (12.3%). Incidence of peri\u2010implantitis was observed in 22.2% of patients and 9.4% of implants. In the final multilevel multiple logistic regression model, the following factors were associated with occurrence of peri\u2010implantitis: periodontitis severity (stage IV periodontitis: OR\u2009=\u200941.29; 95% CI: 4.10\u2013415.54), periodontal bone loss\/age ratio (&gt;\u20091: OR\u2009=\u20098.87; 95% CI: 1.47\u201353.73), smoking (current smokers: OR\u2009=\u20097.84; 95% CI: 1.83\u201333.50), sleep duration (&gt;\u20097\u2009h: OR\u2009=\u200919.97; 95% CI: 1.69\u2013236.39), implant location (incisor: OR\u2009=\u200960.60; 95% CI: 4.04\u2013908.33), restoration type (full\u2010arch fixed restorations: OR\u2009=\u200989.84; 95% CI: 3.66\u20132202.97), and restoration margin location (juxta\u2010marginal: OR\u2009=\u200914.17; 95% CI: 1.20\u2013166.76). Keratinized tissue width assessed at baseline was not associated with incidence of peri\u2010implantitis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Approximately one in five patients and one in 10 implants experienced incident peri\u2010implantitis over a nearly four\u2010year period. Periodontitis (Stage IV and Grade C), lifestyles (smoking and sleep duration), implant location, and prosthetic factors (restoration type and margin location) emerged as risk factors for peri\u2010implantitis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jre.13367","type":"journal-article","created":{"date-parts":[[2025,1,13]],"date-time":"2025-01-13T06:19:44Z","timestamp":1736749184000},"page":"1222-1236","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Incidence and Risk Factors of Peri\u2010Implantitis Over Time\u2014A Prospective Cohort Study"],"prefix":"10.1111","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5646-083X","authenticated-orcid":false,"given":"Mario","family":"Romandini","sequence":"first","affiliation":[{"name":"Section of Periodontology, Faculty of Odontology University Complutense  Madrid 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