{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T07:39:38Z","timestamp":1782977978373,"version":"3.54.5"},"reference-count":50,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,1,12]],"date-time":"2025-01-12T00:00:00Z","timestamp":1736640000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Periodontal Research"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>This study aimed to evaluate and compare the results of combination therapy involving bone grafting and two different resorbable collagen membranes in 1\u2010, 2\u2010 and 3\u2010wall infrabony defects.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A total of 174 patients with infrabony defects (\u2265\u20097\u2009mm periodontal probing depth) were randomized to receive deproteinized bovine bone mineral (DBBM) with either a native porcine non\u2010crosslinked collagen membrane (N\u2010CM, control,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200987) or a novel porcine crosslinked collagen membrane (C\u2010CM, test,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200987). Clinical parameters, including periodontal probing depth (PPD), clinical attachment level (CAL), and gingival recession (GR), were recorded at baseline, 12\u2009weeks, and 24\u2009weeks. Radiographic evaluations measured linear bone gain (LBG) and percentage of bone fill (%BF) at baseline and 24\u2009weeks. Generalized Estimating Equations (GEE) were used to identify predictors of clinical outcomes. The primary outcome was the total effectiveness rate based on a composite outcome score integrating clinical and radiographic parameters at 24\u2009weeks.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      One hundred seventy three patients completed the study. At 24\u2009weeks, mean improvements in PPD were 4.17\u2009\u00b1\u20091.48\u2009mm and 4.16\u2009\u00b1\u20090.97\u2009mm for the control and test groups, respectively, while CAL gains were 3.69\u2009\u00b1\u20091.32\u2009mm and 3.60\u2009\u00b1\u20091.81\u2009mm. Radiographic linear bone gain was 3.12\u2009\u00b1\u20092.19\u2009mm in the control group and 3.00\u2009\u00b1\u20091.92\u2009mm in the test group. Subgroup analysis showed trends favoring the test group for PPD (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.046) and CAL (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.042) improvements in 1\u2010wall defects. The total effectiveness rate was 96.55% in the control group and 95.35% in the test group, with a difference of \u22121.2% (95% CI: \u22125.88% to 3.47%). Among those with effective results, the test group had a higher proportion achieving significantly effective outcomes compared to the control group (96.5% vs. 86.2%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.032). Regression analysis identified treatment group, defect morphology, and baseline defect depth as significant predictors of PPD and CAL outcomes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The novel porcine crosslinked collagen membrane demonstrated non\u2010inferiority to the native non\u2010crosslinked membrane in periodontal regeneration. Regression analysis highlighted defect morphology and baseline defect depth as key predictors of outcomes, while subgroup analysis suggested potential advantages of the C\u2010CM in challenging defect morphologies, such as 1\u2010wall defects. These findings provide valuable insights into clinical decision\u2010making. However, the findings are limited by the short\u2010term nature of the study (24\u2009weeks), and further long\u2010term investigations are needed to confirm these preliminary results and assess their clinical relevance.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration<\/jats:title>\n                    <jats:p>ClinicalTrials.gov identifier: NCT04851847<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jre.13382","type":"journal-article","created":{"date-parts":[[2025,1,12]],"date-time":"2025-01-12T08:33:36Z","timestamp":1736670816000},"page":"1086-1100","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Crosslinked Versus Non\u2010Crosslinked Resorbable Collagen Membranes for Periodontal Regeneration: A Multicenter, Randomized, Double\u2010Blind, Non\u2010Inferiority Clinical Trial"],"prefix":"10.1111","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9675-1420","authenticated-orcid":false,"given":"Yiwei","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Periodontology, Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine  Shanghai China"},{"name":"College of Stomatology, Shanghai Jiao Tong University; National Center for Stomatology; National Clinical Research Center for Oral Diseases; Shanghai Key Laboratory of Stomatology Shanghai Research Institute of Stomatology  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fuhua","family":"Yan","sequence":"additional","affiliation":[{"name":"Nanjing Stomatological Hospital, Affiliated Hospital of Medical School, Institute of Stomatology Nanjing University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lili","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Periodontology, The Second Affiliated Hospital, College of Medicine Zhejiang University  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Periodontics, West China Hospital of Stomatology Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mo","family":"Liu","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation Sun Yat\u2010Sen Memorial Hospital  Guangzhou China"},{"name":"Department of Periodontology Sun Yat\u2010Sen Memorial Hospital of sun Yat\u2010Sen University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3821-5480","authenticated-orcid":false,"given":"Shaohua","family":"Ge","sequence":"additional","affiliation":[{"name":"Department of Periodontology, School and Hospital of Stomatology Shandong University  Jinan Shandong China"},{"name":"Shandong Key Laboratory of Oral Tissue Regeneration, Shandong Engineering Research Center of Dental Materials and Oral Tissue Regeneration Shandong Provincial Clinical Research Center for Oral Diseases  Jinan Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3829-1256","authenticated-orcid":false,"given":"Chia\u2010Yu","family":"Chen","sequence":"additional","affiliation":[{"name":"Division of Periodontology, Department of Oral Medicine, Infection and Immunity Harvard School of Dental Medicine  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David M.","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Periodontology, Department of Oral Medicine, Infection and Immunity Harvard School of Dental Medicine  Boston Massachusetts 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