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Taxonomic and functional annotations were performed, followed by analyses of microbial diversity, differential abundance, interspecies networks, predictive modeling, and functional pathway enrichment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Significant differences in both alpha and beta diversity were observed between PH and periodontitis. Several periodontal pathogens were more abundant in disease states, with\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>Capnocytophaga granulosa<\/jats:italic>\n                      <\/jats:styled-content>\n                      and\n                      <jats:italic>Capnocytophaga<\/jats:italic>\n                      sp.\n                      <jats:italic>CM59<\/jats:italic>\n                      enriched in PD\u2010S3gC compared to PD\u2010S3gB. The PD\u2010S3gC group also exhibited a more complex microbial network with increased interspecies connectivity. An 11\u2010species diagnostic model effectively distinguished PH, PD\u2010S3gB, and PD\u2010S3gC. Furthermore, pathways related to motility, chemotaxis, and methane metabolism were significantly enriched in periodontitis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Distinct structural and functional differences in the subgingival microbiome characterize periodontal health and periodontitis. Periodontitis with a rapid rate of progression is marked by specific pathogen overgrowth and enhanced microbial interactions, supporting the development of microbiome\u2010based diagnostics and personalized therapies.<\/jats:p>\n                    <jats:p>\n                      <jats:bold>Trial Registration:<\/jats:bold>\n                      Chinese Clinical Trial Registration: ChiCTR2000039426\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jre.13408","type":"journal-article","created":{"date-parts":[[2025,5,9]],"date-time":"2025-05-09T08:39:37Z","timestamp":1746779977000},"page":"788-798","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Metagenomic Insights Into the Subgingival Microbiome in Periodontal Health and Different Grades of Periodontitis"],"prefix":"10.1111","volume":"60","author":[{"given":"Yan","family":"Zhao","sequence":"first","affiliation":[{"name":"Stomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Zhejiang Provincial Clinical Research Center for Oral Diseases, Key Laboratory of Oral Biomedical Research of Zhejiang Province Cancer Center of Zhejiang University, Engineering Research Center of Oral Biomaterials and Devices of Zhejiang Province  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Song","sequence":"additional","affiliation":[{"name":"Stomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Zhejiang Provincial Clinical Research Center for Oral Diseases, Key Laboratory of Oral Biomedical Research of Zhejiang Province Cancer Center of Zhejiang University, Engineering Research Center of Oral Biomaterials and Devices of Zhejiang Province  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao\u2010Yu","family":"Li","sequence":"additional","affiliation":[{"name":"Stomatology Hospital, School of 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