{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T15:48:01Z","timestamp":1790092081855,"version":"4.0.1"},"reference-count":183,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,5,9]],"date-time":"2025-05-09T00:00:00Z","timestamp":1746748800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Periodontal Research"],"published-print":{"date-parts":[[2025,10]]},"abstract":"ABSTRACT<\/jats:title>\n \n Aim<\/jats:title>\n The objective of this systematic review and meta\u2010analysis was to evaluate the influence of non\u2010surgical periodontal therapy (NSPT) on subgingival microbiota in systemically healthy patients with periodontitis.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n A systematic literature search was conducted in Medline, Embase, LILACS, and the Cochrane Library, supplemented by a manual search for studies investigating the effect of NSPT on subgingival microbiota in systemically healthy patients.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n In this review, 115 studies were included, of which 41 used checkerboard DNA\u2013DNA hybridisation technology, 30 real\u2010time quantitative PCR, 36 bacterial culture, and 8 16S ribosomal ribonucleic acid (rRNA) gene sequencing technology. Meta\u2010analyses showed a significant decrease in mean counts of\n \n Aggregatibacter actinomycetemcomitans<\/jats:italic>\n <\/jats:styled-content>\n (\n \n A. actinomycetemcomitans<\/jats:italic>\n <\/jats:styled-content>\n ),\n \n Treponema denticola<\/jats:italic>\n <\/jats:styled-content>\n (\n \n T. denticola<\/jats:italic>\n <\/jats:styled-content>\n ),\n \n Porphyromonas gingivalis<\/jats:italic>\n <\/jats:styled-content>\n (\n \n P. gingivalis<\/jats:italic>\n <\/jats:styled-content>\n ),\n \n Tannerella forsythia<\/jats:italic>\n <\/jats:styled-content>\n (\n \n T. forsythia<\/jats:italic>\n <\/jats:styled-content>\n ),\n \n Eubacterium nodatum<\/jats:italic>\n <\/jats:styled-content>\n (\n \n E. nodatum<\/jats:italic>\n <\/jats:styled-content>\n ),\n \n Prevotella intermedia<\/jats:italic>\n <\/jats:styled-content>\n (\n \n P. intermedia<\/jats:italic>\n <\/jats:styled-content>\n ), and\n \n Campylobacter rectus<\/jats:italic>\n <\/jats:styled-content>\n (\n \n C. rectus<\/jats:italic>\n <\/jats:styled-content>\n ) after NSPT. Supportive periodontal care provided a further decrease in mean counts of\n \n P. gingivalis<\/jats:italic>\n <\/jats:styled-content>\n and\n \n T. denticola<\/jats:italic>\n <\/jats:styled-content>\n at 6\u2009months after NSPT. Qualitative analysis of 16S rRNA gene sequencing studies indicated significant effects of NSPT on the relative abundance of selected disease\u2010and health\u2010associated species and genera, whereas findings on changes in alpha and beta diversity in the subgingival microbiome were heterogeneous.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n This systematic review showed that NSPT leads to significant reduction of mean abundance of disease\u2010associated microbial species. However, 16S rRNA gene sequencing studies reported heterogeneous findings, which may be associated with methodological aspects. To deepen the understanding of the effect of NSPT on subgingival microbiota, further studies, powered for microbiome changes and with clustered analysis of site\u2010specific samples, are needed.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/jre.13409","type":"journal-article","created":{"date-parts":[[2025,5,9]],"date-time":"2025-05-09T08:49:21Z","timestamp":1746780561000},"page":"963-993","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["The Effect of Non\u2010Surgical Periodontal Therapy on Subgingival Microbiota: A Systematic Review and Meta\u2010Analysis"],"prefix":"10.1111","volume":"60","author":[{"given":"Anna","family":"Krajewski","sequence":"first","affiliation":[{"name":"Centre for Oral Clinical Research, Institute of Dentistry, Faculty of Medicine and Dentistry Queen Mary University of London London 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