{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T15:34:21Z","timestamp":1791819261574,"version":"4.3.4"},"reference-count":139,"publisher":"Wiley","license":[{"start":{"date-parts":[[2025,8,4]],"date-time":"2025-08-04T00:00:00Z","timestamp":1754265600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,8,4]],"date-time":"2025-08-04T00:00:00Z","timestamp":1754265600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Periodontal Research"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Nearly three decades have now passed since autologous platelet concentrates (APCs) were introduced into clinical practice. Harnessing the body's innate intrinsic capacity for healing, the concepts of platelet\u2010rich plasma (PRP) and platelet\u2010rich fibrin (PRF) emerged to concentrate growth factors and cells at supra\u2010physiological levels. Nearly three decades ago, Professor Robert Marx demonstrated that PRP\u2014obtained via centrifugation of whole blood with anti\u2010coagulants\u2014could accelerate healing across a wide range of indications in both dentistry and medicine. Subsequent research showed that eliminating anti\u2010coagulants, leading to the development of PRF, resulted in an even more natural and faster healing process. In dentistry, APCs have been consistently shown to accelerate healing of both soft and hard tissues, either as standalone treatments or in combination with other biomaterials. PRF, in particular, has demonstrated benefits within several dental applications, spanning from root coverage, periodontal regeneration of intra\u2010bony and furcation defects, ridge preservation, third molar extraction healing, sinus grafting, guided bone regeneration (GBR), and peri\u2010implant soft tissue healing. Beyond dentistry, PRF has also proven effective in various medical indications\u2014improving outcomes in the treatment of diabetic ulcers, managing joint pain and cartilage degradation in sports medicine, and enhancing outcomes in esthetic medicine. This review highlights the evolution of APCs, with a focus on their clinical applications and recent technological advancements. These include horizontal centrifugation techniques for PRF and more refined protocols for producing concentrated PRF (C\u2010PRF). Lastly, the article introduces extended\u2010PRF (e\u2010PRF) membranes, created through heat\u2010induced albumin denaturation, which prolong membrane degradation from the typical 2\u20133\u2009weeks to up to 4\u2009months. These innovative e\u2010PRF membranes, composed of albumin gel and liquid PRF (Alb\u2010PRF), are now being used as alternatives to collagen membranes in routine dental procedures.<\/jats:p>","DOI":"10.1111\/jre.70013","type":"journal-article","created":{"date-parts":[[2025,8,4]],"date-time":"2025-08-04T13:56:41Z","timestamp":1754315801000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Thirty\u2009Years of Autologous Platelet Concentrates: From Platelet\u2010Rich Plasma to Platelet\u2010Rich Fibrin"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3290-3418","authenticated-orcid":false,"given":"Richard J.","family":"Miron","sequence":"first","affiliation":[{"name":"Department of Periodontology University of Bern  Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5780-3777","authenticated-orcid":false,"given":"Nathan E.","family":"Estrin","sequence":"additional","affiliation":[{"name":"Lake Erie College of Osteopathic Medicine School of Dental Medicine  Bradenton Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7306-9795","authenticated-orcid":false,"given":"Paras","family":"Ahmad","sequence":"additional","affiliation":[{"name":"Department of Research Advanced PRF Education  Jupiter Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2944-5305","authenticated-orcid":false,"given":"Nima","family":"Farshidfar","sequence":"additional","affiliation":[{"name":"Department of Periodontology University of Bern  Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1511-9085","authenticated-orcid":false,"given":"Masako","family":"Fujioka\u2010Kobayashi","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery Shimane University Faculty of Medicine  Izumo Shimane Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8702-5291","authenticated-orcid":false,"given":"Yufeng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Oral Implantology University of Wuhan  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5646-083X","authenticated-orcid":false,"given":"Mario","family":"Romandini","sequence":"additional","affiliation":[{"name":"Perio\u2010Implant Innovation Center, Institute for Integrated Oral, Craniofacial and Sensory Research\u2014National Clinical Research Center of Stomatology, Ninth People's Hospital Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5400-9009","authenticated-orcid":false,"given":"Reinhard","family":"Gruber","sequence":"additional","affiliation":[{"name":"Department of Oral Biology University of Vienna  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,8,4]]},"reference":[{"key":"e_1_2_15_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0952-3278(89)90154-3"},{"key":"e_1_2_15_3_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.1990.30790385523.x"},{"key":"e_1_2_15_4_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/783983"},{"key":"e_1_2_15_5_1","volume-title":"Understanding Platelet Rich Fibrin: Quintessence","author":"Miron R. J.","year":"2021"},{"key":"e_1_2_15_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12521"},{"key":"e_1_2_15_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12903-021-01497-0"},{"key":"e_1_2_15_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2007.01.037"},{"key":"e_1_2_15_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-016-1719-1"},{"key":"e_1_2_15_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12538"},{"key":"e_1_2_15_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12582"},{"key":"e_1_2_15_12_1","doi-asserted-by":"publisher","DOI":"10.4103\/GFSC.GFSC_23_18"},{"key":"e_1_2_15_13_1","doi-asserted-by":"publisher","DOI":"10.1177\/00220345610400010601"},{"key":"e_1_2_15_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/JPER.18-0553"},{"key":"e_1_2_15_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12550"},{"key":"e_1_2_15_16_1","doi-asserted-by":"publisher","DOI":"10.1563\/aaid-joi-D-14-00138"},{"key":"e_1_2_15_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-017-2063-9"},{"key":"e_1_2_15_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12626"},{"key":"e_1_2_15_19_1","doi-asserted-by":"publisher","DOI":"10.1080\/09537104.2017.1401058"},{"key":"e_1_2_15_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2019.04.002"},{"key":"e_1_2_15_21_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20246243"},{"key":"e_1_2_15_22_1","doi-asserted-by":"publisher","DOI":"10.4103\/jisp.jisp_201_17"},{"key":"e_1_2_15_23_1","doi-asserted-by":"publisher","DOI":"10.4103\/ccd.ccd_367_18"},{"key":"e_1_2_15_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/php.13628"},{"key":"e_1_2_15_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/wrr.13083"},{"key":"e_1_2_15_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.12955"},{"key":"e_1_2_15_27_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18020331"},{"key":"e_1_2_15_28_1","doi-asserted-by":"publisher","DOI":"10.1080\/09537104.2017.1293807"},{"key":"e_1_2_15_29_1","doi-asserted-by":"publisher","DOI":"10.14715\/cmb\/2024.70.4.25"},{"key":"e_1_2_15_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/odi.13501"},{"key":"e_1_2_15_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ortho.2022.100715"},{"key":"e_1_2_15_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-024-67704-4"},{"key":"e_1_2_15_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.a.36734"},{"key":"e_1_2_15_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12625"},{"key":"e_1_2_15_35_1","doi-asserted-by":"publisher","DOI":"10.1080\/09537104.2020.1754382"},{"key":"e_1_2_15_36_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12903-020-01299-w"},{"key":"e_1_2_15_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-019-03147-w"},{"key":"e_1_2_15_38_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-020-03303-7"},{"key":"e_1_2_15_39_1","doi-asserted-by":"publisher","DOI":"10.1080\/09537104.2024.2316745"},{"key":"e_1_2_15_40_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-021-04268-x"},{"key":"e_1_2_15_41_1","first-page":"45","article-title":"Evidence for Contamination of Silica Microparticles in Advanced Platelet\u2010Rich Fibrin Matrices Prepared Using Silica\u2010Coated Plastic Tubes","volume":"7","author":"Tsujino T.","year":"2019","journal-title":"Biomedicine"},{"key":"e_1_2_15_42_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-020-03400-7"},{"key":"e_1_2_15_43_1","doi-asserted-by":"publisher","DOI":"10.1089\/ten.teb.2016.0233"},{"key":"e_1_2_15_44_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-017-2133-z"},{"key":"e_1_2_15_45_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12598"},{"key":"e_1_2_15_46_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202308848"},{"key":"e_1_2_15_47_1","doi-asserted-by":"publisher","DOI":"10.3390\/ma14123319"},{"key":"e_1_2_15_48_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12583"},{"key":"e_1_2_15_49_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12609"},{"key":"e_1_2_15_50_1","doi-asserted-by":"publisher","DOI":"10.1002\/JPER.17-0466"},{"key":"e_1_2_15_51_1","doi-asserted-by":"publisher","DOI":"10.1155\/2024\/8850664"},{"key":"e_1_2_15_52_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12600"},{"key":"e_1_2_15_53_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12554"},{"key":"e_1_2_15_54_1","first-page":"285","article-title":"Efficacy of Platelet\u2010Rich Fibrin on Bone Formation, Part 2: Guided Bone Regeneration, Sinus Elevation and Implant Therapy","volume":"14","author":"Fujioka\u2010Kobayashi M.","year":"2021","journal-title":"International Journal of Oral Implantology"},{"key":"e_1_2_15_55_1","doi-asserted-by":"publisher","DOI":"10.1563\/AAID-JOI-D-13-00129"},{"key":"e_1_2_15_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tripleo.2005.07.012"},{"key":"e_1_2_15_57_1","doi-asserted-by":"publisher","DOI":"10.1111\/cid.12522"},{"key":"e_1_2_15_58_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.13044"},{"key":"e_1_2_15_59_1","doi-asserted-by":"publisher","DOI":"10.1111\/cid.12713"},{"key":"e_1_2_15_60_1","doi-asserted-by":"publisher","DOI":"10.7150\/ijms.5119"},{"key":"e_1_2_15_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcms.2011.04.020"},{"key":"e_1_2_15_62_1","doi-asserted-by":"publisher","DOI":"10.11607\/prd.1419"},{"key":"e_1_2_15_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcms.2012.10.015"},{"key":"e_1_2_15_64_1","first-page":"207","article-title":"Effects of Leukocyte\u2010Platelet Rich Fibrin on Postoperative Complications of Direct Sinus Lifting","volume":"65","author":"Gurler G.","year":"2016","journal-title":"Minerva Stomatologica"},{"key":"e_1_2_15_65_1","first-page":"e984","article-title":"Sinus Floor Elevation With Platelet\u2010Rich Fibrin Alone: A Clinical Retrospective Study of 1\u20137\u2009Years","volume":"10","author":"Aoki N.","year":"2018","journal-title":"Journal of Clinical and Experimental Dentistry"},{"key":"e_1_2_15_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tripleo.2007.08.021"},{"key":"e_1_2_15_67_1","first-page":"1075","article-title":"Trial With Platelet\u2010Rich Fibrin and Bio\u2010Oss Used as Grafting Materials in the Treatment of the Severe Maxillar Bone Atrophy: Clinical and Radiological Evaluations","volume":"14","author":"Inchingolo F.","year":"2010","journal-title":"European Review for Medical and Pharmacological Sciences"},{"key":"e_1_2_15_68_1","doi-asserted-by":"publisher","DOI":"10.1097\/ID.0000000000000327"},{"key":"e_1_2_15_69_1","doi-asserted-by":"publisher","DOI":"10.4103\/ams.ams_168_18"},{"key":"e_1_2_15_70_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2009.090252"},{"key":"e_1_2_15_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stomax.2008.10.006"},{"key":"e_1_2_15_72_1","doi-asserted-by":"publisher","DOI":"10.11607\/jomi.7371"},{"key":"e_1_2_15_73_1","doi-asserted-by":"publisher","DOI":"10.1097\/ID.0b013e3181faa8af"},{"key":"e_1_2_15_74_1","doi-asserted-by":"publisher","DOI":"10.11607\/jomi.2613"},{"key":"e_1_2_15_75_1","doi-asserted-by":"publisher","DOI":"10.1097\/ID.0b013e3181f57288"},{"key":"e_1_2_15_76_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2013.130260"},{"key":"e_1_2_15_77_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40729-020-00266-y"},{"key":"e_1_2_15_78_1","doi-asserted-by":"publisher","DOI":"10.1111\/cid.13121"},{"key":"e_1_2_15_79_1","doi-asserted-by":"publisher","DOI":"10.3390\/jfb13040194"},{"key":"e_1_2_15_80_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12604"},{"key":"e_1_2_15_81_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tice.2019.101326"},{"key":"e_1_2_15_82_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-019-03018-4"},{"key":"e_1_2_15_83_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.13503"},{"key":"e_1_2_15_84_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2012.09.018"},{"key":"e_1_2_15_85_1","doi-asserted-by":"publisher","DOI":"10.1111\/cid.12146"},{"key":"e_1_2_15_86_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcms.2019.01.023"},{"key":"e_1_2_15_87_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep46452"},{"key":"e_1_2_15_88_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcms.2014.01.034"},{"key":"e_1_2_15_89_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-32936-8"},{"key":"e_1_2_15_90_1","doi-asserted-by":"publisher","DOI":"10.1002\/9781119406792.ch11"},{"key":"e_1_2_15_91_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12563"},{"key":"e_1_2_15_92_1","first-page":"ZC18","article-title":"Effect of Platelet Rich Fibrin (PRF) on Peri\u2010Implant Soft Tissue and Crestal Bone in One\u2010Stage Implant Placement: A Randomized Controlled Trial","volume":"9","author":"Boora P.","year":"2015","journal-title":"Journal of Clinical and Diagnostic Research: JCDR"},{"key":"e_1_2_15_93_1","doi-asserted-by":"publisher","DOI":"10.11607\/jomi.3897"},{"key":"e_1_2_15_94_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijom.2017.07.025"},{"key":"e_1_2_15_95_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijom.2018.01.001"},{"key":"e_1_2_15_96_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40729-016-0044-4"},{"key":"e_1_2_15_97_1","doi-asserted-by":"publisher","DOI":"10.1002\/cap.10259"},{"key":"e_1_2_15_98_1","doi-asserted-by":"publisher","DOI":"10.11607\/prd.1861"},{"key":"e_1_2_15_99_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12546"},{"key":"e_1_2_15_100_1","doi-asserted-by":"publisher","DOI":"10.1590\/abd1806-4841.20164741"},{"key":"e_1_2_15_101_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10787-023-01318-6"},{"key":"e_1_2_15_102_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1524-475X.1994.20305.x"},{"key":"e_1_2_15_103_1","first-page":"333","article-title":"Platelet Gel: A New Therapeutic Tool With Great Potential","volume":"15","author":"Piccin A.","year":"2016","journal-title":"Blood Transfusion"},{"key":"e_1_2_15_104_1","unstructured":"Control CfD Department of Health and Human Services \u201cNational Diabetes Statistics Report 2020 Estimates of Diabetes and Its Burden in the United States [Internet] \u201d(2021)."},{"key":"e_1_2_15_105_1","doi-asserted-by":"publisher","DOI":"10.2522\/ptj.20080020"},{"key":"e_1_2_15_106_1","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.2248"},{"key":"e_1_2_15_107_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.293.2.217"},{"key":"e_1_2_15_108_1","first-page":"32","article-title":"The Impact of Diabetic Foot Ulcer Pain on Patient Quality of Life","volume":"7","author":"Thomas M.","year":"2011","journal-title":"Wounds"},{"key":"e_1_2_15_109_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-5491.1990.tb01300.x"},{"key":"e_1_2_15_110_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12605"},{"key":"e_1_2_15_111_1","doi-asserted-by":"publisher","DOI":"10.14260\/jemds\/2016\/1689"},{"key":"e_1_2_15_112_1","first-page":"172","article-title":"Efficacy of Autologous Platelet\u2010Rich Fibrin in Chronic Cutaneous Ulcer: A Randomized Controlled Trial","volume":"3","author":"Shreyas N. S.","year":"2017","journal-title":"IP Indian Journal of Clinical and Experimental Dermatology"},{"key":"e_1_2_15_113_1","article-title":"The Efficacy of Platelet\u2010Rich Fibrin in the Management of Chronic Nonhealing Ulcers of the Lower Limb","volume":"14","author":"Singampalli Z.","year":"2022","journal-title":"Cureus"},{"key":"e_1_2_15_114_1","doi-asserted-by":"publisher","DOI":"10.30574\/wjarr.2023.18.1.0508"},{"key":"e_1_2_15_115_1","first-page":"91","article-title":"Leukocytes and Platelets Rich Fibrin in the Treatment of Skin Lesions","volume":"17","author":"Rescigno E.","year":"2016","journal-title":"Acta Phlebologica"},{"key":"e_1_2_15_116_1","doi-asserted-by":"publisher","DOI":"10.1080\/09537104.2017.1327654"},{"key":"e_1_2_15_117_1","doi-asserted-by":"publisher","DOI":"10.4103\/JCAS.JCAS_130_19"},{"key":"e_1_2_15_118_1","doi-asserted-by":"publisher","DOI":"10.21608\/ejhm.2021.205096"},{"key":"e_1_2_15_119_1","doi-asserted-by":"publisher","DOI":"10.4103\/ijd.ijd_204_22"},{"key":"e_1_2_15_120_1","doi-asserted-by":"publisher","DOI":"10.1186\/s41038-019-0149-0"},{"key":"e_1_2_15_121_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtv.2021.04.009"},{"key":"e_1_2_15_122_1","doi-asserted-by":"publisher","DOI":"10.4103\/JCAS.JCAS_116_22"},{"key":"e_1_2_15_123_1","doi-asserted-by":"publisher","DOI":"10.1177\/1947603520931170"},{"key":"e_1_2_15_124_1","first-page":"135","article-title":"Stromal Vascular Fraction With Platelet\u2010Rich Fibrin for Osteoarthritis Management in Knee and Hip Osteoarthritis: A Retrospective 2\u2010Year Follow\u2010Up Study","volume":"6","author":"Og\u00e9us T.","year":"2024","journal-title":"Journal of Orthopedics and Sports Medicine"},{"key":"e_1_2_15_125_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jormas.2024.101998"},{"key":"e_1_2_15_126_1","doi-asserted-by":"publisher","DOI":"10.4103\/njms.njms_498_21"},{"key":"e_1_2_15_127_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcms.2023.01.017"},{"key":"e_1_2_15_128_1","doi-asserted-by":"publisher","DOI":"10.1080\/09537104.2020.1717455"},{"key":"e_1_2_15_129_1","doi-asserted-by":"publisher","DOI":"10.1080\/09537104.2020.1775188"},{"key":"e_1_2_15_130_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12537"},{"key":"e_1_2_15_131_1","first-page":"537","article-title":"Histological Evaluation of Gingival and Intrabony Periodontal Defects Treated With Platelet\u2010Rich Fibrin Using Different Protocols: A Canine Study","volume":"19","author":"Shirakata Y.","year":"2021","journal-title":"Oral Health & Preventive Dentistry"},{"key":"e_1_2_15_132_1","doi-asserted-by":"publisher","DOI":"10.1111\/cid.13427"},{"key":"e_1_2_15_133_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12546"},{"key":"e_1_2_15_134_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12522"},{"key":"e_1_2_15_135_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12561"},{"key":"e_1_2_15_136_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12557"},{"key":"e_1_2_15_137_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12551"},{"key":"e_1_2_15_138_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12520"},{"key":"e_1_2_15_139_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.11607\/prd.7567","article-title":"Exosome\u2010Mediated Alveolar Ridge Augmentation: A First Human Case Report With Histology","author":"Estrin N.","year":"2025","journal-title":"International Journal of Periodontics & Restorative Dentistry"},{"key":"e_1_2_15_140_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2018.05.021"}],"container-title":["Journal of Periodontal Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jre.70013","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jre.70013","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jre.70013","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T10:56:56Z","timestamp":1788260216000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jre.70013"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,4]]},"references-count":139,"alternative-id":["10.1111\/jre.70013"],"URL":"https:\/\/doi.org\/10.1111\/jre.70013","archive":["Portico"],"relation":{},"ISSN":["0022-3484","1600-0765"],"issn-type":[{"value":"0022-3484","type":"print"},{"value":"1600-0765","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,4]]},"assertion":[{"value":"2025-04-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-06-27","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-04","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"jre.70013"}}