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After 6\u2009days, the sites were harvested and evaluated using histology, immunohistochemistry, multiplex cytokine assay and untargeted proteomics of the gels, which were examined, informing an integrated multiomics approach analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Both peptide formulations improved the composite histological score compared to HA alone, and HA\u2009+\u2009P6 matched EMD in suppressing oedema, TNF\u2010\u03b1 staining and CD80\n                      <jats:sup>+<\/jats:sup>\n                      macrophages while increasing mannose\u2010receptor labelling. Proteomics revealed that P2 upregulated actin (Q6QAQ1) and histone H2A (F2Z5L5), consistent with active remodelling, whereas EMD reduced trypsin and trypsinogen, indicating a more stabilised wound milieu; HA\u2009+\u2009P6 showed an intermediate yet favourable profile. IL\u20106 levels were lower in both peptide groups and EMD than in HA, and all gels proved noncytotoxic, with HA\u2009+\u2009P6 enhancing cell viability.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>HA\u2009+\u2009P6 suppressed TNF\u2010\u03b1 and trypsin signalling while boosting M2\u2010linked markers and proresolution proteins to the same extent as EMD, whereas plain HA did not. Thus, adding a short proline\u2010rich peptide confers EMD\u2010like early immunomodulation on a fully synthetic HA carrier. These observations, although limited to 6\u2010day soft tissue healing, warrant longer studies in true periodontal regeneration models.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jre.70032","type":"journal-article","created":{"date-parts":[[2025,9,10]],"date-time":"2025-09-10T12:07:39Z","timestamp":1757506059000},"page":"1018-1038","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Multiomics Comparison of Proline\u2010Rich Peptide\u2010Enhanced Hyaluronic Acid Gels Versus Conventional Regenerative Materials: An Early Wound\u2010Healing Model"],"prefix":"10.1111","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9170-0202","authenticated-orcid":false,"given":"\u00d8ystein","family":"\u00d8vreb\u00f8","sequence":"first","affiliation":[{"name":"Department of Biomaterials, Institute of Clinical Dentistry University of Oslo  Oslo Norway"},{"name":"Department of Chemistry, Materials and 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