{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T06:32:44Z","timestamp":1782973964238,"version":"3.54.5"},"reference-count":167,"publisher":"Wiley","license":[{"start":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T00:00:00Z","timestamp":1759104000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Periodontal Research"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Periodontitis is a multifactorial inflammatory disease, traditionally attributed to a bacterial biofilm. Increasing evidence indicates that viruses, especially members of the\n                    <jats:italic>Herpesviridae<\/jats:italic>\n                    family, are frequently detected in periodontal lesions and may influence disease onset and progression. This review provides an overview of viruses present in the oral cavity, including\n                    <jats:italic>Herpesviridae<\/jats:italic>\n                    ,\n                    <jats:italic>Papillomaviridae<\/jats:italic>\n                    ,\n                    <jats:italic>Retroviridae<\/jats:italic>\n                    , SARS\u2010CoV\u20102, and emerging viral taxa such as\n                    <jats:italic>Redondoviridae<\/jats:italic>\n                    and bacteriophages, and summarizes their reported associations with periodontitis. Proposed mechanisms of viral contribution include modulation of local immune responses, facilitation of bacterial overgrowth, direct cytopathic effects on periodontal tissues, and synergistic interactions with classical periodontal pathobionts. Clinical correlations link viral load and co\u2010infections with increased disease severity. Identification of direct causal relationships and therapeutic aspects, such as antiviral and combined antimicrobial approaches, is the subject of current research; however, clinical evidence remains limited. Overall, specific viruses show direct influence on periodontal bacterial pathogens and affect the host immune response, warranting further longitudinal and functional studies to clarify their exact role in periodontitis onset, progression, and treatment.\n                  <\/jats:p>","DOI":"10.1111\/jre.70039","type":"journal-article","created":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T04:15:47Z","timestamp":1759205747000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["The Role of Viruses in the Pathogenesis of Periodontitis"],"prefix":"10.1111","author":[{"given":"Kim Natalie","family":"Stolte","sequence":"first","affiliation":[{"name":"Department of Periodontology Oral Medicine and Oral Surgery, Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin, Humboldt\u2010Universit\u00e4t Zu Berlin, and Berlin Institute of Health  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00f8rgen","family":"Slots","sequence":"additional","affiliation":[{"name":"Division of Periodontology and Diagnostic Sciences, School of Dentistry University of Southern California  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1043-2651","authenticated-orcid":false,"given":"Henrik","family":"Dommisch","sequence":"additional","affiliation":[{"name":"Department of Periodontology Oral Medicine and Oral Surgery, Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin, Humboldt\u2010Universit\u00e4t Zu Berlin, and Berlin Institute of Health  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,9,29]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1128\/JB.00542-10"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12553"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12435"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0757.2008.00279.x"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.2005.00770.x"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.0902-0055.2002.00118.x"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0765.2000.035001017.x"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1999.70.5.478"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1128\/br.35.3.235-241.1971"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01723-14"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.72.3.2010-2021.1998"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-67-9-1759"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2018.00211"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2020.02104"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00705-008-0278-4"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1515\/hsz-2017-0113"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.01885-23"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(13)70109-9"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2019.04.001"},{"issue":"9","key":"e_1_2_12_21_1","article-title":"Coxsackie B Virus\u2010Induced Cardiac Tamponade and Adrenal Insufficiency","volume":"15","author":"Jeong S. 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