{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T19:13:39Z","timestamp":1784402019008,"version":"3.55.0"},"reference-count":31,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T00:00:00Z","timestamp":1761609600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T00:00:00Z","timestamp":1761609600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Periodontal Research"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To analyze the rate, timeline, and risk factors for furcation involvement (FI) progression using a large, multi\u2010center electronic health record database.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective cohort study analyzed 3924 patients with periodontitis and at least 1\u2009year of follow\u2010up from the BigMouth Dental Data Repository. Furcation progression (increase in the maximum recorded furcation grade for a given tooth during the follow\u2010up period) was assessed at both the patient and tooth level. Time\u2010to\u2010event analysis at the patient level was performed using Kaplan\u2013Meier curves and a multivariate Cox Proportional Hazards model to identify predictive factors. At the tooth level, the primary analysis was a multilevel Cox model, with a Fine\u2010Gray competing risks model performed as a secondary analysis to assess the impact of tooth loss.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Over a mean follow\u2010up of 4.7\u2009years, 57.1% of patients experienced furcation progression, with a median time to the first event of 3.6\u2009years. A Cox proportional hazards model identified smoking as the factor most strongly correlated with progression, increasing the risk by 51% (Hazard Ratio [HR]: 1.51), followed by high blood pressure (HR: 1.25) and diabetes (HR: 1.24). At the tooth level, the initial furcation grade showed the strongest association with progression, increasing the hazard by 3.05 times for each unit increase.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Furcation involvement is a progressive event for a majority of patients diagnosed with periodontitis. The risk of progression is correlated with a combination of systemic factors and the patient's overall periodontal status, but the factor most strongly correlated with a tooth's future deterioration is its own initial furcation grade.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jre.70049","type":"journal-article","created":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T14:42:59Z","timestamp":1761662579000},"page":"273-282","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Progression of Furcation Involvement: A Multi\u2010Center Cohort Study of Incidence, Timing, and Risk Factors"],"prefix":"10.1111","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6951-8794","authenticated-orcid":false,"given":"Georgios S.","family":"Chatzopoulos","sequence":"first","affiliation":[{"name":"Division of Periodontology School of Dentistry, University of Minnesota  Minneapolis Minnesota USA"},{"name":"Faculty of Dentistry, Health Sciences Aristotle University of Thessaloniki  Thessaloniki Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Larry F.","family":"Wolff","sequence":"additional","affiliation":[{"name":"Division of Periodontology School of Dentistry, University of Minnesota  Minneapolis Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,10,28]]},"reference":[{"key":"e_1_2_13_2_1","first-page":"211","article-title":"Subgingival Host\u2010Microbiome Metatranscriptomic Changes Following Scaling and Root Planing in Grade II\/III Periodontitis","volume":"50","author":"Duran\u2010Pinedo A. 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