{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T18:37:35Z","timestamp":1792521455727,"version":"4.5.0"},"reference-count":119,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T00:00:00Z","timestamp":1767916800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Periodontal Research"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>Enamel matrix derivative (EMD) has been utilized in periodontology for over 30\u2009years to promote periodontal tissue regeneration by mimicking key biological processes of root development. Preclinical studies confirmed that EMD induces the formation of new cementum, periodontal ligament, and alveolar bone, especially when applied to dry, conditioned root surfaces with minimal\/no blood contamination. After reviewing the biological foundations for the functioning of EMD, this systematic review analyzed the efficacy of EMD across multiple clinical indications.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Randomized clinical trials (RCTs) fulfilling specific inclusion criteria were searched and included up to April 15th, 2025. Two review authors independently screened the titles and abstracts, carried out full\u2010text analysis, extracted the data from the published reports, and performed the risk of bias assessment through the RoB2 tool of the Cochrane Collaboration. Disagreements were solved by consensus. Studies were categorized for four clinical indications: (1) nonsurgical treatment of periodontitis; (2) regenerative surgery of intrabony defects; (3) regenerative surgery of furcation defects; and (4) root coverage procedures of gingival recessions. The study results were summarized using random effects meta\u2010analyses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 67 RCTs (9 nonsurgical, 41 intrabony, 4 furcation, and 13 recession), involving 2552 participants and 3521 defects, were included. In meta\u2010analyses, EMD demonstrated superior outcomes in intrabony defects, achieving an added gain of 1.00\u2009mm in probing pocket depth (PPD) reduction and 1.14\u2009mm in clinical attachment level (CAL) over open flap debridement alone. The addition of EMD with bone grafts did not yield any significant improvement in clinical outcomes, except for greater CAL gain (0.79) when combined with xenografts. Non\u2010resorbable membranes showed a more substantial reduction in PPD (1.08\u2009mm) than EMD. For root coverage procedures, EMD showed modest but non\u2010statistically significant improvements, with substantial heterogeneity across studies. A modest additional advantage in PPD reduction (0.30\u2009mm) was found with the adjunctive application of EMD compared to subgingival instrumentation alone, although no enhancements were noticed in CAL. Evidence supporting its use in furcation defects remains limited.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>EMD is one of the few biological agents with human histologic evidence supporting periodontal regeneration. This is reflected in improved clinical outcomes when used in regenerative surgery for intrabony defects. Despite its biological plausibility for broader therapeutic applications, further high\u2010quality randomized clinical trials are needed to better define its role in nonsurgical treatment of periodontitis, root coverage procedures, and regenerative surgery of furcation involvement. Future research should also focus on optimizing application protocols and exploring novel combinations with other regenerative biomaterials.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jre.70069","type":"journal-article","created":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T14:08:57Z","timestamp":1767967737000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["30\u2009Years of Enamel Matrix Derivative (\n                    <scp>EMD<\/scp>\n                    ): Biological Foundations and Systematic Review With Meta\u2010Analyses Across Multiple Clinical Indications"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3290-3418","authenticated-orcid":false,"given":"Richard J.","family":"Miron","sequence":"first","affiliation":[{"name":"Department of Periodontology University of Bern  Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2944-5305","authenticated-orcid":false,"given":"Nima","family":"Farshidfar","sequence":"additional","affiliation":[{"name":"Department of Periodontology University of Bern  Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu\u2010Kang","family":"Tu","sequence":"additional","affiliation":[{"name":"Institute of Health Data Analytics and Statistics, College of Public Health National Taiwan University  Taipei Taiwan"},{"name":"Department of Dentistry, National Taiwan University Hospital National Taiwan University  Taipei Taiwan"},{"name":"Health Data Research Center National Taiwan University  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chian\u2010Heng","family":"Su","sequence":"additional","affiliation":[{"name":"Health Data Research Center National Taiwan University  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7306-9795","authenticated-orcid":false,"given":"Paras","family":"Ahmad","sequence":"additional","affiliation":[{"name":"Department of Research Advanced PRF Education  Jupiter Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathan E.","family":"Estrin","sequence":"additional","affiliation":[{"name":"Lake Erie College of Osteopathic Medicine School of Dental Medicine  Bradenton Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5400-9009","authenticated-orcid":false,"given":"Reinhard","family":"Gruber","sequence":"additional","affiliation":[{"name":"Department of Oral Biology University of Vienna  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshinori","family":"Shirakata","sequence":"additional","affiliation":[{"name":"Department of Periodontology Kagoshima University Graduate School of Medical and Dental Sciences  Kagoshima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dieter D.","family":"Bosshardt","sequence":"additional","affiliation":[{"name":"Department of Periodontology University of Bern  Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5646-083X","authenticated-orcid":false,"given":"Mario","family":"Romandini","sequence":"additional","affiliation":[{"name":"Ninth People's Hospital Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2836-5477","authenticated-orcid":false,"given":"Anton","family":"Sculean","sequence":"additional","affiliation":[{"name":"Department of Periodontology University of Bern  Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,9]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1111\/jcpe.12546","article-title":"Twenty Years of Enamel Matrix Derivative: The Past, the Present and the Future","volume":"43","author":"Miron R. J.","year":"2016","journal-title":"Journal of Clinical Periodontology"},{"key":"e_1_2_11_3_1","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1902\/cap.2011.110047","article-title":"Enamel Matrix Proteins and Periodontal Wound Healing and Regeneration","volume":"1","author":"Sculean A.","year":"2011","journal-title":"Clinical Advances in Periodontics"},{"key":"e_1_2_11_4_1","article-title":"30\u2009Years of Enamel Matrix Derivative: Mimicking Tooth Development as a Clinical Concept","author":"Miron R. J.","year":"2025","journal-title":"Periodontology 2000"},{"key":"e_1_2_11_5_1","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1111\/jre.13328","article-title":"Characterization of Oral Biomarkers During Early Healing at Augmented Dental Implant Sites","volume":"60","author":"Tavelli L.","year":"2024","journal-title":"Journal of Periodontal Research"},{"key":"e_1_2_11_6_1","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1111\/prd.12522","article-title":"Twenty\u2010Five Years of Recombinant Human Growth Factors rhPDGF\u2010BB and rhBMP\u20102 in Oral Hard and Soft Tissue Regeneration","volume":"94","author":"Galarraga\u2010Vinueza M. E.","year":"2024","journal-title":"Periodontology 2000"},{"key":"e_1_2_11_7_1","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1111\/jre.13328","article-title":"Characterization of Oral Biomarkers During Early Healing at Augmented Dental Implant Sites","volume":"60","author":"Tavelli L.","year":"2025","journal-title":"Journal of Periodontal Research"},{"key":"e_1_2_11_8_1","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202308848","article-title":"From Basic Science to Clinical Practice: A Review of Current Periodontal\/Mucogingival Regenerative Biomaterials","volume":"11","author":"De Lauretis A.","year":"2024","journal-title":"Advanced Science"},{"key":"e_1_2_11_9_1","doi-asserted-by":"crossref","DOI":"10.3390\/ma14123319","article-title":"Biomaterials for Periodontal and Peri\u2010Implant Regeneration","volume":"14","author":"Mancini L.","year":"2021","journal-title":"Materials (Basel)"},{"key":"e_1_2_11_10_1","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1111\/jre.13331","article-title":"Local Application of 0.8% Hyaluronic Acid Gel as an Adjunct to Minimally Invasive Nonsurgical Treatment of Periodontal Intrabony Defects\u2014A Randomized Clinical Trial","volume":"60","author":"Gundogdu Ezer U.","year":"2025","journal-title":"Journal of Periodontal Research"},{"key":"e_1_2_11_11_1","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1111\/jre.13235","article-title":"A Photoresponsive Recombinant Human Amelogenin\u2010Loaded Hyaluronic Acid Hydrogel Promotes Bone Regeneration","volume":"59","author":"Hsia T. L.","year":"2024","journal-title":"Journal of Periodontal Research"},{"key":"e_1_2_11_12_1","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1111\/jre.13201","article-title":"Hyaluronic Acid Enhances Cell Migration, Viability, and Mineralized Tissue\u2010Specific Genes in Cementoblasts","volume":"59","author":"Hakki S. S.","year":"2024","journal-title":"Journal of Periodontal Research"},{"key":"e_1_2_11_13_1","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.1111\/jre.13310","article-title":"Recombinant Human Fibroblast Growth Factor and Autogenous Bone for Periodontal Regeneration: Alone or in Combination? A Randomized Clinical Trial","volume":"59","author":"Kojima K.","year":"2024","journal-title":"Journal of Periodontal Research"},{"key":"e_1_2_11_14_1","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1111\/j.1600-051X.1997.tb00247.x","article-title":"Enamel Matrix, Cementum Development and Regeneration","volume":"24","author":"Hammarstrom L.","year":"1997","journal-title":"Journal of Clinical Periodontology"},{"key":"e_1_2_11_15_1","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1111\/j.1600-051X.1997.tb00249.x","article-title":"Formulation of Enamel Matrix Derivative for Surface Coating. Kinetics and Cell Colonization","volume":"24","author":"Gestrelius S.","year":"1997","journal-title":"Journal of Clinical Periodontology"},{"key":"e_1_2_11_16_1","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1111\/j.1600-051X.1997.tb00250.x","article-title":"In Vitro Studies on Periodontal Ligament Cells and Enamel Matrix Derivative","volume":"24","author":"Gestrelius S.","year":"1997","journal-title":"Journal of Clinical Periodontology"},{"key":"e_1_2_11_17_1","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1111\/j.1600-051X.1997.tb00248.x","article-title":"Periodontal Regeneration in a Buccal Dehiscence Model in Monkeys After Application of Enamel Matrix Proteins","volume":"24","author":"Hammarstrom L.","year":"1997","journal-title":"Journal of Clinical Periodontology"},{"key":"e_1_2_11_18_1","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1111\/j.1600-051X.1997.tb00253.x","article-title":"Enamel Matrix Derivative (EMDOGAIN) in the Treatment of Intrabony Periodontal Defects","volume":"24","author":"Heijl L.","year":"1997","journal-title":"Journal of Clinical Periodontology"},{"key":"e_1_2_11_19_1","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1111\/j.1600-051X.1997.tb00252.x","article-title":"Clinical Safety of Enamel Matrix Derivative (EMDOGAIN) in the Treatment of Periodontal Defects","volume":"24","author":"Zetterstrom O.","year":"1997","journal-title":"Journal of Clinical Periodontology"},{"key":"e_1_2_11_20_1","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1111\/j.1601-6343.2009.01459.x","article-title":"Enamel Matrix Proteins; Old Molecules for New Applications","volume":"12","author":"Lyngstadaas S. P.","year":"2009","journal-title":"Orthodontics & Craniofacial Research"},{"key":"e_1_2_11_21_1","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1902\/jop.2011.110480","article-title":"Adsorption of Enamel Matrix Proteins to a Bovine\u2010Derived Bone Grafting Material and Its Regulation of Cell Adhesion, Proliferation, and Differentiation","volume":"83","author":"Miron R. J.","year":"2012","journal-title":"Journal of Periodontology"},{"key":"e_1_2_11_22_1","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1902\/jop.2011.110404","article-title":"Enamel Matrix Protein Adsorption to Root Surfaces in the Presence or Absence of Human Blood","volume":"83","author":"Miron R. J.","year":"2012","journal-title":"Journal of Periodontology"},{"key":"e_1_2_11_23_1","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1007\/s00784-002-0171-6","article-title":"Presence of an Enamel Matrix Protein Derivative on Human Teeth Following Periodontal Surgery","volume":"6","author":"Sculean A.","year":"2002","journal-title":"Clinical Oral Investigations"},{"key":"e_1_2_11_24_1","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1007\/s00784-003-0212-9","article-title":"Immunohistochemical Evaluation of Matrix Molecules Associated With Wound Healing Following Treatment With an Enamel Matrix Protein Derivative in Humans","volume":"7","author":"Sculean A.","year":"2003","journal-title":"Clinical Oral Investigations"},{"key":"e_1_2_11_25_1","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/S0003-9969(02)00164-4","article-title":"Immunohistochemical Investigation on the Pattern of Vimentin Expression in Regenerated and Intact Monkey and Human Periodontal Ligament","volume":"48","author":"Sculean A.","year":"2003","journal-title":"Archives of Oral Biology"},{"key":"e_1_2_11_26_1","doi-asserted-by":"crossref","DOI":"10.1136\/bmj.n71","article-title":"The PRISMA 2020 Statement: An Updated Guideline for Reporting Systematic Reviews","volume":"372","author":"Page M. J.","year":"2021","journal-title":"BMJ"},{"key":"e_1_2_11_27_1","doi-asserted-by":"crossref","DOI":"10.1136\/bmj.l4898","article-title":"RoB 2: A Revised Tool for Assessing Risk of Bias in Randomised Trials","volume":"366","author":"Sterne J. A.","year":"2019","journal-title":"BMJ"},{"key":"e_1_2_11_28_1","first-page":"1","article-title":"Estimating the Sample Mean and Standard Deviation From the Sample Size, Median, Range and\/or Interquartile Range","volume":"14","author":"Wan X.","year":"2014","journal-title":"BMC Medical Research Methodology"},{"key":"e_1_2_11_29_1","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1002\/jrsm.1304","article-title":"Statistical Approaches to Adjusting Weights for Dependent Arms in Network Meta\u2010Analysis","volume":"9","author":"Su Y. X.","year":"2018","journal-title":"Research Synthesis Methods"},{"key":"e_1_2_11_30_1","doi-asserted-by":"crossref","first-page":"3","DOI":"10.4103\/ds.DS-D-22-00154","article-title":"Using Grading of Recommendations Assessment, Development, and Evaluation (GRADE) to Rate the Certainty of Evidence of Study Outcomes From Systematic Reviews: A Quick Tutorial","volume":"41","author":"Shao S.\u2010C.","year":"2023","journal-title":"Dermatologica Sinica"},{"key":"e_1_2_11_31_1","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1034\/j.1600-051X.2003.00374.x","article-title":"Evaluation of Enamel Matrix Derivative as an Adjunct to Non\u2010Surgical Periodontal Therapy","volume":"30","author":"Gutierrez M. A.","year":"2003","journal-title":"Journal of Clinical Periodontology"},{"key":"e_1_2_11_32_1","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1111\/jcpe.13438","article-title":"Flapless Application of Enamel Matrix Derivative in Periodontal Retreatment: A Multicentre Randomized Feasibility Trial","volume":"48","author":"Jentsch H. F. R.","year":"2021","journal-title":"Journal of Clinical Periodontology"},{"key":"e_1_2_11_33_1","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1002\/JPER.19-0579","article-title":"Application of Enamel Matrix Derivative in Conjunction With Non\u2010Surgical Therapy for Treatment of Moderate to Severe Periodontitis: A 12\u2010Month, Randomized Prospective, Multicenter Study","volume":"92","author":"Schallhorn R. A.","year":"2021","journal-title":"Journal of Periodontology"},{"key":"e_1_2_11_34_1","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1111\/j.1600-051X.2005.00664.x","article-title":"Enamel Matrix Proteins and Systemic Antibiotics as Adjuncts to Non\u2010Surgical Periodontal Treatment: Clinical Effects","volume":"32","author":"Mombelli A.","year":"2005","journal-title":"Journal of Clinical Periodontology"},{"key":"e_1_2_11_35_1","first-page":"431","article-title":"The Evaluation of Enamel Matrix Derivative on Subgingival Microbial Environment in Non\u2010Surgical Periodontal Therapy","volume":"20","author":"Wyganowska\u2010Swiatkowska M.","year":"2013","journal-title":"Annals of Agricultural and Environmental Medicine"},{"key":"e_1_2_11_36_1","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1111\/jcpe.13567","article-title":"Enamel Matrix Derivative as an Adjunct to Minimally Invasive Non\u2010Surgical Treatment of Intrabony Defects: A Randomized Clinical Trial","volume":"49","author":"Anoixiadou S.","year":"2022","journal-title":"Journal of Clinical Periodontology"},{"key":"e_1_2_11_37_1","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1111\/jcpe.13074","article-title":"Enamel Matrix Derivative Stabilizes Blood Clot and Improves Clinical Healing in Deep Pockets After Flapless Periodontal Therapy: A Randomized Clinical Trial","volume":"46","author":"Graziani F.","year":"2019","journal-title":"Journal of Clinical Periodontology"},{"key":"e_1_2_11_38_1","doi-asserted-by":"crossref","first-page":"6493","DOI":"10.1007\/s00784-023-05254-1","article-title":"Effects of Enamel Matrix Derivative in Nonsurgical Periodontal Therapy on Pro\u2010Inflammatory Profiles, Microbial Environment and Clinical Outcome: A Randomized Clinical Trial","volume":"27","author":"Wehner C.","year":"2023","journal-title":"Clinical Oral Investigations"},{"key":"e_1_2_11_39_1","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.1111\/jcpe.14028","article-title":"The Flapless Approach With and Without Enamel Matrix Derivatives for the Treatment of Intrabony Defects: A Randomized Controlled Clinical Trial","volume":"51","author":"Aimetti M.","year":"2024","journal-title":"Journal of Clinical Periodontology"},{"key":"e_1_2_11_40_1","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1034\/j.1600-051X.1997.00833.x","article-title":"The Use of Barrier Membranes and Enamel Matrix Proteins in the Treatment of Angular Bone Defects. A Prospective Controlled Clinical Study","volume":"26","author":"Pontoriero R.","year":"1999","journal-title":"Journal of Clinical Periodontology"},{"key":"e_1_2_11_41_1","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1034\/j.1600-051x.2000.027008603.x","article-title":"Comparison of Treatments of Infrabony Defects With Enamel Matrix Derivative, Guided Tissue Regeneration With a Nonresorbable Membrane and Widman Modified Flap. A Pilot Study","volume":"27","author":"Silvestri M.","year":"2000","journal-title":"Journal of Clinical Periodontology"},{"key":"e_1_2_11_42_1","doi-asserted-by":"crossref","first-page":"1821","DOI":"10.1902\/jop.2000.71.12.1821","article-title":"Enamel Matrix Derivative in the Treatment of Human Intrabony Osseous Defects","volume":"71","author":"Okuda K.","year":"2000","journal-title":"Journal of Periodontology"},{"key":"e_1_2_11_43_1","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1902\/jop.2001.72.1.25","article-title":"A Comparative Study Utilizing Open Flap Debridement With and Without Enamel Matrix Derivative in the Treatment of Periodontal Intrabony Defects: A 12\u2010Month Re\u2010Entry Study","volume":"72","author":"Froum S. J.","year":"2001","journal-title":"Journal of Periodontology"},{"key":"e_1_2_11_44_1","doi-asserted-by":"crossref","first-page":"1695","DOI":"10.1902\/jop.2001.72.12.1695","article-title":"Treatment of Intrabony Defects With Enamel Matrix Proteins or Bioabsorbable Membranes. A 4\u2010Year Follow\u2010Up Split\u2010Mouth Study","volume":"72","author":"Sculean A.","year":"2001","journal-title":"Journal of Periodontology"},{"key":"e_1_2_11_45_1","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1034\/j.1600-051X.2002.290407.x","article-title":"Enamel Matrix Proteins in the Regenerative Therapy of Deep Intrabony Defects","volume":"29","author":"Tonetti M. S.","year":"2002","journal-title":"Journal of Clinical Periodontology"},{"key":"e_1_2_11_46_1","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1902\/jop.2002.73.1.3","article-title":"Enamel Matrix Proteins and Guided Tissue Regeneration With Titanium\u2010Reinforced Expanded Polytetrafluoroethylene Membranes in the Treatment of Infrabony Defects: A Comparative Controlled Clinical Trial","volume":"73","author":"Zucchelli G.","year":"2002","journal-title":"Journal of Periodontology"},{"key":"e_1_2_11_47_1","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1034\/j.1600-051X.2003.00013.x","article-title":"Microsurgical Access Flap and Enamel Matrix Derivative for the Treatment of Periodontal Intrabony Defects: A Controlled Clinical Study","volume":"30","author":"Wachtel H.","year":"2003","journal-title":"Journal of Clinical Periodontology"},{"key":"e_1_2_11_48_1","first-page":"461","article-title":"Evaluation of Efficacy of Enamel Matrix Derivative in the Treatment of Intrabony Defects: A 24\u2010Month Multicenter Study","volume":"25","author":"Francetti L.","year":"2005","journal-title":"International Journal of Periodontics and Restorative Dentistry"},{"key":"e_1_2_11_49_1","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1111\/j.1600-051X.2006.01010.x","article-title":"Primary Flap Closure Combined With Emdogain Alone or Emdogain and Cerasorb in the Treatment of Intra\u2010Bony Defects","volume":"33","author":"Bokan I.","year":"2006","journal-title":"Journal of Clinical Periodontology"},{"key":"e_1_2_11_50_1","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1111\/j.1600-051X.2009.01451.x","article-title":"Microsurgical Access Flap in Conjunction With Enamel Matrix Derivative for the Treatment of Intra\u2010Bony Defects: A Controlled Clinical Trial","volume":"36","author":"Fickl S.","year":"2009","journal-title":"Journal of Clinical Periodontology"},{"key":"e_1_2_11_51_1","first-page":"125","article-title":"Treatment of Infrabony Defects With or Without Enamel Matrix Proteins: A 24\u2010Month Follow\u2010Up Randomized Pilot Study","volume":"41","author":"Chambrone D.","year":"2010","journal-title":"Quintessence International"},{"key":"e_1_2_11_52_1","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1111\/j.1600-051X.2011.01705.x","article-title":"Clinical and Radiographic Outcomes of the Modified Minimally Invasive Surgical Technique With and Without Regenerative Materials: A Randomized\u2010Controlled Trial in Intra\u2010Bony Defects","volume":"38","author":"Cortellini P.","year":"2011","journal-title":"Journal of Clinical Periodontology"},{"key":"e_1_2_11_53_1","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1902\/jop.2012.110656","article-title":"Enamel Matrix Derivative, Alone or Associated With a Synthetic Bone Substitute, in the Treatment of 1\u2010To 2\u2010Wall Periodontal Defects","volume":"84","author":"De Leonardis D.","year":"2013","journal-title":"Journal of Periodontology"},{"key":"e_1_2_11_54_1","doi-asserted-by":"crossref","first-page":"764","DOI":"10.3109\/00016357.2012.728245","article-title":"Five Years Clinical Results Following Treatment of Human Intra\u2010Bony Defects With an Enamel Matrix Derivative: A Randomized Controlled Trial","volume":"71","author":"Bhutda G.","year":"2013","journal-title":"Acta Odontologica Scandinavica"},{"key":"e_1_2_11_55_1","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1007\/s00784-009-0369-y","article-title":"Comparative Study of DFDBA in Combination With Enamel Matrix Derivative Versus DFDBA Alone for Treatment of Periodontal Intrabony Defects at 12 Months Post\u2010Surgery","volume":"15","author":"Aspriello S. D.","year":"2011","journal-title":"Clinical Oral Investigations"},{"key":"e_1_2_11_56_1","first-page":"259","article-title":"Clinical Evaluation of an Enamel Matrix Protein Derivative (Emdogain) Combined With a Bovine\u2010Derived Xenograft (Bio\u2010Oss) for the Treatment of Intrabony Periodontal Defects in Humans","volume":"22","author":"Sculean A.","year":"2002","journal-title":"International Journal of Periodontics and Restorative Dentistry"},{"key":"e_1_2_11_57_1","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1002\/JPER.19-0432","article-title":"Adjunctive Use of Enamel Matrix Derivatives to Porcine\u2010Derived Xenograft for the Treatment of One\u2010Wall Intrabony Defects: Two\u2010Year Longitudinal Results of a Randomized Controlled Clinical Trial","volume":"91","author":"Lee J. H.","year":"2020","journal-title":"Journal of Periodontology"},{"key":"e_1_2_11_58_1","doi-asserted-by":"crossref","first-page":"322","DOI":"10.12701\/jyms.2022.00325","article-title":"Regenerative Potential of Biphasic Calcium Phosphate and Enamel Matrix Derivatives in the Treatment of Isolated Interproximal Intrabony Defects: A Randomized Controlled Trial","volume":"39","author":"Pal P. C.","year":"2022","journal-title":"Journal of Yeungnam Medical Science"},{"key":"e_1_2_11_59_1","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1902\/jop.2007.060142","article-title":"Effect of Autogenous Cortical Bone Particulate in Conjunction With Enamel Matrix Derivative in the Treatment of Periodontal Intraosseous Defects","volume":"78","author":"Guida L.","year":"2007","journal-title":"Journal of Periodontology"},{"key":"e_1_2_11_60_1","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1111\/j.1600-051X.2010.01567.x","article-title":"Healing of Two and Three Wall Intrabony Periodontal Defects Following Treatment With an Enamel Matrix Derivative Combined With Autogenous Bone","volume":"37","author":"Yilmaz S.","year":"2010","journal-title":"Journal of Clinical Periodontology"},{"key":"e_1_2_11_61_1","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1902\/jop.2014.130520","article-title":"Efficacy of Enamel Matrix Derivative With Freeze\u2010Dried Bone Allograft or Demineralized Freeze\u2010Dried Bone Allograft in Intrabony Defects: A Randomized Trial","volume":"85","author":"Ogihara S.","year":"2014","journal-title":"Journal of Periodontology"},{"key":"e_1_2_11_62_1","doi-asserted-by":"crossref","first-page":"1725","DOI":"10.1902\/jop.2003.74.12.1725","article-title":"Enamel Matrix Proteins and Bovine Porous Bone Mineral in the Treatment of Intrabony Defects: A Comparative Controlled Clinical Trial","volume":"74","author":"Zucchelli G.","year":"2003","journal-title":"Journal of Periodontology"},{"key":"e_1_2_11_63_1","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1111\/j.1600-051X.2004.00635.x","article-title":"Healing of Human Intrabony Defects Following Regenerative Periodontal Therapy With an Enamel Matrix Protein Derivative Alone or Combined With a Bioactive Glass: A Controlled Clinical Study","volume":"32","author":"Sculean A.","year":"2005","journal-title":"Journal of Clinical Periodontology"},{"key":"e_1_2_11_64_1","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1007\/s00784-011-0611-2","article-title":"Four\u2010Year Results Following Treatment of Intrabony Periodontal Defects With an Enamel Matrix Derivative Alone or Combined With a Biphasic Calcium Phosphate","volume":"16","author":"Pietruska M.","year":"2012","journal-title":"Clinical Oral Investigations"},{"key":"e_1_2_11_65_1","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1902\/jop.2016.160459","article-title":"Treatment of Non\u2010Contained Infrabony Defects With Enamel Matrix Derivative Alone or in Combination With Biphasic Calcium Phosphate Bone Graft: A 12\u2010Month Randomized Controlled Clinical Trial","volume":"88","author":"Losada M.","year":"2017","journal-title":"Journal of Periodontology"},{"key":"e_1_2_11_66_1","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1034\/j.1600-051x.2001.028005397.x","article-title":"Treatment of Intrabony Defects With Enamel Matrix Proteins and Guided Tissue Regeneration. A Prospective Controlled Clinical Study","volume":"28","author":"Sculean A.","year":"2001","journal-title":"Journal of Clinical Periodontology"},{"key":"e_1_2_11_67_1","first-page":"595","article-title":"A Comparative Study of Combined Treatment With a Collagen Membrane and Enamel Matrix Proteins for the Regeneration of Intraosseous Defects","volume":"22","author":"Minabe M.","year":"2002","journal-title":"International Journal of Periodontics and Restorative Dentistry"},{"key":"e_1_2_11_68_1","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1902\/jop.2004.75.5.726","article-title":"Treatment of Intrabony Defects With Enamel Matrix Proteins or Barrier Membranes: Results From a Multicenter Practice\u2010Based Clinical Trial","volume":"75","author":"Sanz M.","year":"2004","journal-title":"Journal of Periodontology"},{"key":"e_1_2_11_69_1","doi-asserted-by":"crossref","first-page":"2281","DOI":"10.1902\/jop.2008.080135","article-title":"Treatment of Intrabony Defects Using Guided Tissue Regeneration or Enamel Matrix Derivative: A 3\u2010Year Prospective Randomized Clinical Study","volume":"79","author":"Crea A.","year":"2008","journal-title":"Journal of Periodontology"},{"key":"e_1_2_11_70_1","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1902\/jop.2010.100144","article-title":"Clinical Outcomes After Treatment of Non\u2010Contained Intrabony Defects With Enamel Matrix Derivative or Guided Tissue Regeneration: A 12\u2010Month Randomized Controlled Clinical Trial","volume":"82","author":"Siciliano V. I.","year":"2011","journal-title":"Journal of Periodontology"},{"key":"e_1_2_11_71_1","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1111\/j.1600-051X.2005.00754.x","article-title":"The Combined Use of Enamel Matrix Proteins and a Tetracycline\u2010Coated Expanded Polytetrafluoroethylene Barrier Membrane in the Treatment of Intra\u2010Osseous Defects","volume":"32","author":"Sipos P. M.","year":"2005","journal-title":"Journal of Clinical Periodontology"},{"key":"e_1_2_11_72_1","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1111\/j.0303-6979.2004.00437.x","article-title":"Enamel Matrix Proteins in the Treatment of Intra\u2010Bony Defects: A Prospective 24\u2010Month Clinical Trial","volume":"31","author":"Francetti L.","year":"2004","journal-title":"Journal of Clinical Periodontology"},{"key":"e_1_2_11_73_1","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1902\/jop.2005.76.1.129","article-title":"Clinical and Radiographic Effects of Enamel Matrix Derivative in the Treatment of Intrabony Periodontal Defects: A 12\u2010Month Longitudinal Placebo\u2010Controlled Clinical Trial in Adult Periodontitis Patients","volume":"76","author":"Rosing C. K.","year":"2005","journal-title":"Journal of Periodontology"},{"key":"e_1_2_11_74_1","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1034\/j.1600-051X.2003.10146.x","article-title":"Comparison of Infrabony Defects Treated With Enamel Matrix Derivative Versus Guided Tissue Regeneration With a Nonresorbable Membrane: A Multicenter Controlled Clinical Trial","volume":"30","author":"Silvestri M.","year":"2003","journal-title":"Journal of Clinical Periodontology"},{"key":"e_1_2_11_75_1","first-page":"43","article-title":"The Efficacy of Enamel Matrix Derivative (Emdogain) for the Treatment of Deep Infrabony Periodontal Defects: A Placebo\u2010Controlled Randomised Clinical Trial","volume":"2","author":"Grusovin M. G.","year":"2009","journal-title":"European Journal of Oral Implantology"},{"key":"e_1_2_11_76_1","doi-asserted-by":"crossref","first-page":"1400","DOI":"10.1002\/JPER.19-0623","article-title":"Effects of Enamel Matrix Derivative on Clinical and Inflammatory Outcomes in Periodontal Maintenance Patients: Randomized Controlled Clinical Trial","volume":"91","author":"Jasa E. E.","year":"2020","journal-title":"Journal of Periodontology"},{"key":"e_1_2_11_77_1","doi-asserted-by":"crossref","first-page":"2793","DOI":"10.1007\/s00784-021-04256-1","article-title":"Apical Approach in Periodontal Reconstructive Surgery With Enamel Matrix Derivate and Enamel Matrix Derivate Plus Bone Substitutes: A Randomized, Controlled Clinical Trial","volume":"26","author":"Moreno Rodr\u00edguez J. A.","year":"2022","journal-title":"Clinical Oral Investigations"},{"key":"e_1_2_11_78_1","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1111\/j.1600-051X.2011.01726.x","article-title":"A Multi\u2010Centre Randomized Controlled Clinical Trial on the Treatment of Intra\u2010Bony Defects With Enamel Matrix Derivatives\/Synthetic Bone Graft or Enamel Matrix Derivatives Alone: Results After 12 Months","volume":"38","author":"Meyle J.","year":"2011","journal-title":"Journal of Clinical Periodontology"},{"key":"e_1_2_11_79_1","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1111\/j.1600-051X.2010.01614.x","article-title":"Enamel Matrix Derivative Proteins for the Treatment of Proximal Class II Furcation Involvements: A Prospective 24\u2010Month Randomized Clinical Trial","volume":"37","author":"Casarin R. C.","year":"2010","journal-title":"Journal of Clinical Periodontology"},{"key":"e_1_2_11_80_1","doi-asserted-by":"crossref","first-page":"1188","DOI":"10.1902\/jop.2004.75.9.1188","article-title":"A Randomized Clinical Trial Comparing Enamel Matrix Derivative and Membrane Treatment of Buccal Class II Furcation Involvement in Mandibular Molars. Part II: Secondary Outcomes","volume":"75","author":"Meyle J.","year":"2004","journal-title":"Journal of Periodontology"},{"key":"e_1_2_11_81_1","doi-asserted-by":"crossref","first-page":"1597","DOI":"10.1007\/s00784-015-1642-x","article-title":"Enamel Matrix Protein Derivative and\/or Synthetic Bone Substitute for the Treatment of Mandibular Class II Buccal Furcation Defects. A 12\u2010Month Randomized Clinical Trial","volume":"20","author":"Queiroz L. A.","year":"2016","journal-title":"Clinical Oral Investigations"},{"key":"e_1_2_11_82_1","doi-asserted-by":"crossref","first-page":"e58","DOI":"10.11607\/prd.1428","article-title":"Evaluation of the Effectiveness of Enamel Matrix Derivative, Bone Grafts, and Membrane in the Treatment of Mandibular Class II Furcation Defects","volume":"33","author":"Jaiswal R.","year":"2013","journal-title":"International Journal of Periodontics and Restorative Dentistry"},{"key":"e_1_2_11_83_1","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1034\/j.1600-051x.2002.290106.x","article-title":"Comparative Study of Emdogain and Coronally Advanced Flap Technique in the Treatment of Human Gingival Recessions. A Prospective Controlled Clinical Study","volume":"29","author":"Hagewald S.","year":"2002","journal-title":"Journal of Clinical Periodontology"},{"key":"e_1_2_11_84_1","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1111\/j.1600-051X.2005.00831.x","article-title":"Coronally Advanced Flap With or Without Enamel Matrix Derivative for Root Coverage: A 2\u2010Year Study","volume":"32","author":"Del Pizzo M.","year":"2005","journal-title":"Journal of Clinical Periodontology"},{"key":"e_1_2_11_85_1","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1902\/jop.2006.77.1.7","article-title":"Enamel Matrix Derivative and Coronal Flaps to Cover Marginal Tissue Recessions","volume":"77","author":"Castellanos A.","year":"2006","journal-title":"Journal of Periodontology"},{"key":"e_1_2_11_86_1","first-page":"E304","article-title":"A Comparative Study of the Long Term Results of Root Coverage With Connective Tissue Graft or Enamel Matrix Protein: 24\u2010Month Results","volume":"14","author":"Abolfazli N.","year":"2009","journal-title":"Medicina Oral, Patolog\u00eda Oral y Cirug\u00eda Bucal"},{"key":"e_1_2_11_87_1","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1111\/j.1600-0765.2011.01381.x","article-title":"EMD or Subepithelial Connective Tissue Graft for the Treatment of Single Gingival Recessions: A Pilot Study","volume":"46","author":"Alkan E.","year":"2011","journal-title":"Journal of Periodontal Research"},{"key":"e_1_2_11_88_1","doi-asserted-by":"crossref","first-page":"619","DOI":"10.11607\/prd.1337","article-title":"Enamel Matrix Derivative (Emdogain) or Subepithelial Connective Tissue Graft for the Treatment of Adjacent Multiple Gingival Recessions: A Pilot Study","volume":"33","author":"Alkan E. A.","year":"2013","journal-title":"International Journal of Periodontics and Restorative Dentistry"},{"key":"e_1_2_11_89_1","doi-asserted-by":"crossref","first-page":"463","DOI":"10.2334\/josnusd.52.463","article-title":"Application of Subepithelial Connective Tissue Graft With or Without Enamel Matrix Derivative for Root Coverage: A Split\u2010Mouth Randomized Study","volume":"52","author":"Henriques P. S.","year":"2010","journal-title":"Journal of Oral Science"},{"key":"e_1_2_11_90_1","doi-asserted-by":"crossref","DOI":"10.1590\/1807-3107bor-2019.vol33.0006","article-title":"The Effect of Enamel Matrix Derivatives on Root Coverage: A 12\u2010Month Follow\u2010Up of a Randomized Clinical Trial","volume":"33","author":"Aydinyurt H. S.","year":"2019","journal-title":"Brazilian Oral Research"},{"key":"e_1_2_11_91_1","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.1902\/jop.2003.74.8.1110","article-title":"Evaluation of Human Recession Defects Treated With Coronally Advanced Flaps and Either Enamel Matrix Derivative or Connective Tissue. Part 1: Comparison of Clinical Parameters","volume":"74","author":"McGuire M. K.","year":"2003","journal-title":"Journal of Periodontology"},{"key":"e_1_2_11_92_1","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1007\/s00784-018-2506-y","article-title":"Does Enamel Matrix Derivative Application Improve Clinical Outcomes After Semilunar Flap Surgery? A Randomized Clinical Trial","volume":"23","author":"Fran\u00e7a\u2010Grohmann I. L.","year":"2019","journal-title":"Clinical Oral Investigations"},{"key":"e_1_2_11_93_1","first-page":"133","article-title":"Subepithelial Connective Tissue Graft for Treatment of Gingival Recessions With and Without Enamel Matrix Derivative: A Multicenter, Randomized Controlled Clinical Trial","volume":"31","author":"Rasperini G.","year":"2011","journal-title":"International Journal of Periodontics and Restorative Dentistry"},{"key":"e_1_2_11_94_1","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1111\/jre.12039","article-title":"Subepithelial Connective Tissue Graft With or Without Enamel Matrix Derivative for the Treatment of Miller Class I and II Gingival Recessions: A Controlled Randomized Clinical Trial","volume":"48","author":"Roman A.","year":"2013","journal-title":"Journal of Periodontal Research"},{"key":"e_1_2_11_95_1","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1002\/JPER.19-0058","article-title":"Subepithelial Connective Tissue Graft With or Without Enamel Matrix Derivative for the Treatment of Multiple Class III\u2010IV Recessions in Lower Anterior Teeth: A 3\u2010Year Randomized Clinical Trial","volume":"91","author":"Mercado F.","year":"2020","journal-title":"Journal of Periodontology"},{"key":"e_1_2_11_96_1","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1902\/jop.2002.73.4.401","article-title":"Clinical Evaluation of an Enamel Matrix Protein Derivative Combined With a Bioactive Glass for the Treatment of Intrabony Periodontal Defects in Humans","volume":"73","author":"Sculean A.","year":"2002","journal-title":"Journal of Periodontology"},{"key":"e_1_2_11_97_1","article-title":"Use of Enamel Matrix Derivative in Minimally Invasive\/Flapless Approaches: A Systematic Review With Meta\u2010Analysis","volume":"20","author":"Estrin N. E.","year":"2022","journal-title":"Oral Health & Preventive Dentistry"},{"key":"e_1_2_11_98_1","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1902\/jop.2010.100454","article-title":"The Role of Enamel Matrix Derivative Protein in Minimally Invasive Surgery in Treating Intrabony Defects in Single\u2010Rooted Teeth: A Randomized Clinical Trial","volume":"82","author":"Ribeiro F. V.","year":"2011","journal-title":"Journal of Periodontology"},{"key":"e_1_2_11_99_1","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1111\/j.1600-051X.2004.00542.x","article-title":"Prognostic Factors for Alveolar Regeneration: Effect of a Space\u2010Providing Biomaterial on Guided Tissue Regeneration","volume":"31","author":"Polimeni G.","year":"2004","journal-title":"Journal of Clinical Periodontology"},{"key":"e_1_2_11_100_1","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1111\/jcpe.13270","article-title":"Local Application of Enamel Matrix Derivative Prevents Acute Systemic Inflammation After Periodontal Regenerative Surgery: A Randomized Controlled Clinical Trial","volume":"47","author":"Graziani F.","year":"2020","journal-title":"Journal of Clinical Periodontology"},{"key":"e_1_2_11_101_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/jre.13370","article-title":"Periodontology: The Past, the Present, the Future","volume":"60","author":"Lindhe J.","year":"2025","journal-title":"Journal of Periodontal Research"},{"key":"e_1_2_11_102_1","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1111\/j.1600-051X.2008.01352.x","article-title":"Improved Wound Stability With a Modified Minimally Invasive Surgical Technique in the Regenerative Treatment of Isolated Interdental Intrabony Defects","volume":"36","author":"Cortellini P.","year":"2009","journal-title":"Journal of Clinical Periodontology"},{"key":"e_1_2_11_103_1","doi-asserted-by":"crossref","first-page":"e79","DOI":"10.11607\/prd.1628","article-title":"The Soft Tissue Wall Technique for the Regenerative Treatment of Non\u2010Contained Infrabony Defects: A Case Series","volume":"33","author":"Rasperini G.","year":"2013","journal-title":"International Journal of Periodontics and Restorative Dentistry"},{"key":"e_1_2_11_104_1","doi-asserted-by":"crossref","first-page":"673","DOI":"10.11607\/prd.3083","article-title":"Connective Tissue Graft Wall Technique and Enamel Matrix Derivative for the Treatment of Infrabony Defects: Case Reports","volume":"37","author":"Zucchelli G.","year":"2017","journal-title":"International Journal of Periodontics and Restorative Dentistry"},{"key":"e_1_2_11_105_1","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1902\/jop.2009.080420","article-title":"Single\u2010Flap Approach With Buccal Access in Periodontal Reconstructive Procedures","volume":"80","author":"Trombelli L.","year":"2009","journal-title":"Journal of Periodontology"},{"key":"e_1_2_11_106_1","doi-asserted-by":"crossref","DOI":"10.1186\/s12903-019-0766-9","article-title":"Early Wound Healing Outcomes After Regenerative Periodontal Surgery With Enamel Matrix Derivatives or Guided Tissue Regeneration: A Systematic Review","volume":"19","author":"Rojas M. A.","year":"2019","journal-title":"BMC Oral Health"},{"key":"e_1_2_11_107_1","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1111\/j.1600-051X.2006.01020.x","article-title":"A Minimally Invasive Surgical Technique With an Enamel Matrix Derivative in the Regenerative Treatment of Intra\u2010Bony Defects: A Novel Approach to Limit Morbidity","volume":"34","author":"Cortellini P.","year":"2007","journal-title":"Journal of Clinical Periodontology"},{"key":"e_1_2_11_108_1","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1111\/j.1600-051X.2008.01242.x","article-title":"Single Minimally Invasive Surgical Technique With an Enamel Matrix Derivative to Treat Multiple Adjacent Intra\u2010Bony Defects: Clinical Outcomes and Patient Morbidity","volume":"35","author":"Cortellini P.","year":"2008","journal-title":"Journal of Clinical Periodontology"},{"key":"e_1_2_11_109_1","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1902\/jop.2009.090393","article-title":"Prospective Assessment of the Use of Enamel Matrix Derivative With Minimally Invasive Surgery: 6\u2010Year Results","volume":"81","author":"Harrel S. K.","year":"2010","journal-title":"Journal of Periodontology"},{"key":"e_1_2_11_110_1","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1111\/prd.12081","article-title":"Clinical Concepts for Regenerative Therapy in Furcations","volume":"68","author":"Sanz M.","year":"2015","journal-title":"Periodontology 2000"},{"key":"e_1_2_11_111_1","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1007\/s00784-007-0134-z","article-title":"Efficacy of Open Flap Debridement With and Without Enamel Matrix Derivatives in the Treatment of Mandibular Degree II Furcation Involvement","volume":"11","author":"Chitsazi M. T.","year":"2007","journal-title":"Clinical Oral Investigations"},{"key":"e_1_2_11_112_1","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.1902\/jop.2004.75.8.1150","article-title":"A Randomized Clinical Trial Comparing Enamel Matrix Derivative and Membrane Treatment of Buccal Class II Furcation Involvement in Mandibular Molars. Part I: Study Design and Results for Primary Outcomes","volume":"75","author":"Jepsen S.","year":"2004","journal-title":"Journal of Periodontology"},{"key":"e_1_2_11_113_1","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1111\/j.1600-051X.2006.00947.x","article-title":"A Randomized Clinical Multicentre Trial Comparing Enamel Matrix Derivative and Membrane Treatment of Buccal Class II Furcation Involvement in Mandibular Molars. Part III: Patient Factors and Treatment Outcome","volume":"33","author":"Hoffmann T.","year":"2006","journal-title":"Journal of Clinical Periodontology"},{"key":"e_1_2_11_114_1","doi-asserted-by":"crossref","DOI":"10.1111\/jre.70043","article-title":"Histological Outcomes of Root Coverage Procedures: A Systematic Review With Meta\u2010Analysis","author":"Shanbhag S.","year":"2025","journal-title":"Journal of Periodontal Research"},{"key":"e_1_2_11_115_1","doi-asserted-by":"crossref","first-page":"1871","DOI":"10.1902\/jop.2005.76.11.1871","article-title":"Coverage of Miller Class I and II Recession Defects Using Enamel Matrix Proteins Versus Coronally Advanced Flap Technique: A 2\u2010Year Report","volume":"76","author":"Spahr A.","year":"2005","journal-title":"Journal of Periodontology"},{"key":"e_1_2_11_116_1","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1902\/jop.2004.75.7.949","article-title":"A Comparative Study of Coronally Advanced Flaps With and Without the Addition of Enamel Matrix Derivative in the Treatment of Marginal Tissue Recession","volume":"75","author":"Cueva M. A.","year":"2004","journal-title":"Journal of Periodontology"},{"key":"e_1_2_11_117_1","doi-asserted-by":"crossref","first-page":"2031","DOI":"10.1902\/jop.2006.050390","article-title":"Root Coverage With a Coronally Positioned Flap Used in Combination With Enamel Matrix Derivative: 18\u2010Month Clinical Evaluation","volume":"77","author":"Pilloni A.","year":"2006","journal-title":"Journal of Periodontology"},{"key":"e_1_2_11_118_1","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1111\/j.1600-051X.2008.01267.x","article-title":"Treatment of Gingival Recession With Coronally Advanced Flap Procedures: A Systematic Review","volume":"35","author":"Cairo F.","year":"2008","journal-title":"Journal of Clinical Periodontology"},{"key":"e_1_2_11_119_1","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1902\/jop.2006.050008","article-title":"Comparative Study of Two Root Coverage Procedures: A 24\u2010Month Follow\u2010Up Multicenter Study","volume":"77","author":"Moses O.","year":"2006","journal-title":"Journal of Periodontology"},{"key":"e_1_2_11_120_1","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1902\/jop.2003.74.8.1126","article-title":"Evaluation of Human Recession Defects Treated With Coronally Advanced Flaps and Either Enamel Matrix Derivative or Connective Tissue. Part 2: Histological Evaluation","volume":"74","author":"McGuire M. K.","year":"2003","journal-title":"Journal of Periodontology"}],"container-title":["Journal of Periodontal Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jre.70069","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T14:09:11Z","timestamp":1767967751000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jre.70069"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,9]]},"references-count":119,"alternative-id":["10.1111\/jre.70069"],"URL":"https:\/\/doi.org\/10.1111\/jre.70069","archive":["Portico"],"relation":{},"ISSN":["0022-3484","1600-0765"],"issn-type":[{"value":"0022-3484","type":"print"},{"value":"1600-0765","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,9]]},"assertion":[{"value":"2025-08-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-03","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-09","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"jre.70069"}}