{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T14:47:39Z","timestamp":1786632459516,"version":"build-2736575974"},"reference-count":50,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T00:00:00Z","timestamp":1775865600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T00:00:00Z","timestamp":1775865600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Periodontal Research"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>\n                      This study aimed to investigate the anti\u2010proliferative effects of resveratrol on gingival fibroblasts derived from amlodipine\u2010induced gingival overgrowths and its impact on the levels of transforming growth factor\u2010\n                      <jats:italic>\u03b2<\/jats:italic>\n                      1 (TGF\u2010\n                      <jats:italic>\u03b2<\/jats:italic>\n                      1), connective tissue growth factor (CTGF), collagen type I (COL\u20101), interleukin\u20106 (IL\u20106), transglutaminase\u20102 (TGM\u20102), and superoxide dismutase (SOD), which play critical roles in collagen and extracellular matrix metabolism in gingival enlargement.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Primary gingival fibroblasts were isolated from patients with amlodipine\u2010induced gingival overgrowth (GO group) and from healthy gingival tissues (H group). Each group was divided into untreated and resveratrol\u2010treated subgroups. Cell proliferation and viability at 24 and 48\u2009h were assessed by MTT assay. The levels of TGF\u2010\n                      <jats:italic>\u03b2<\/jats:italic>\n                      1, CTGF, COL\u20101, IL\u20106, TGM\u20102, and SOD were quantified using ELISA.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      MTT values were significantly higher in the GO group than in the H group at both 24 and 48\u2009h (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.01). Resveratrol treatment significantly decreased proliferation in the GO group at both time points (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). In the GO group, resveratrol reduced TGF\u2010\n                      <jats:italic>\u03b2<\/jats:italic>\n                      1 (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.0090), CTGF (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.0090), TGM\u20102 (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.0088), COL\u20101 (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.0139), and IL\u20106 (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.050) levels at 24\u2009h and significantly increased SOD levels (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.0143).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Resveratrol suppressed cellular proliferation without exerting cytotoxic effects in amlodipine\u2010induced GO, while downregulating fibrosis markers (TGF\u2010\n                      <jats:italic>\u03b2<\/jats:italic>\n                      1, CTGF, COL\u20101, IL\u20106, and TGM\u20102) and restoring diminished SOD synthesis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registiration<\/jats:title>\n                    <jats:p>This study did not involve a clinical trial and therefore registration was not required<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jre.70112","type":"journal-article","created":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T07:37:17Z","timestamp":1775893037000},"page":"716-729","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Anti\u2010Proliferative Effects of Resveratrol on Gingival Fibroblasts Derived From Amlodipine\u2010Induced Gingival Overgrowth"],"prefix":"10.1111","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-9694-364X","authenticated-orcid":false,"given":"Bilkan","family":"Kara","sequence":"first","affiliation":[{"name":"Department of Periodontology, Faculty of Dentistry University of Health Sciences  Ankara Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0657-6177","authenticated-orcid":false,"given":"Nuriye I\u015f\u0131l","family":"Saygun","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Faculty of Dentistry University of Health Sciences  Ankara Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4340-7279","authenticated-orcid":false,"given":"Cansel","family":"K\u00f6se \u00d6zkan","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Technology, Faculty of Pharmacy University of Health Sciences  Ankara Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9894-4891","authenticated-orcid":false,"given":"Melis","family":"\u00d6zg\u00fcl Slezovic","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Faculty of Dentistry Lokman Hekim University  Ankara Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3014-748X","authenticated-orcid":false,"given":"Muhittin Abdulkadir","family":"Serdar","sequence":"additional","affiliation":[{"name":"Department of Medical Biochemistry Ac\u0131badem Mehmet Ali Ayd\u0131nlar University  Ankara Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1007-9456","authenticated-orcid":false,"given":"Mualla P\u0131nar","family":"El\u00e7i","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Institute of Stem Cell Lab University of Health Sciences  Ankara Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2679-9100","authenticated-orcid":false,"given":"Alpdo\u011fan","family":"Kantarci","sequence":"additional","affiliation":[{"name":"Department of Developmental and Surgical Science, School of Dental Medicine University of Minnesota  Minneapolis Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,11]]},"reference":[{"key":"e_1_2_13_2_1","first-page":"268","volume-title":"Newman and Carranza's Cl\u0131inical Periodontology and Implantology","author":"Kantarci A.","year":"2024"},{"issue":"6","key":"e_1_2_13_3_1","first-page":"339","article-title":"Gingival Overgrowth With Calcium\u2010Channel Blockers","volume":"54","author":"Palattella A.","year":"2005","journal-title":"Minerva Stomatologica"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/PH17081075"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.33314\/JNHRC.V20I4.4363"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/J.1600\u2010051X.1996.TB02072.X"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/154411130401500305"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/J.1600\u20100757.2005.00145.X"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/154405910608500607"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1902\/JOP.2001.72.7.921"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304\u2010419X(90)90013\u2010Q"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.3389\/FCELL.2020.593269\/FULL"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/S10103\u2010024\u201004122\u2010Y"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/S00784\u2010024\u201005771\u20107"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.3390\/CELLS10071842"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1101\/CSHPERSPECT.A016295"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.3390\/IJMS24065448"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1055\/S\u20100030\u20101253228\/ID\/24\/BIB"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.BIOCEL.2011.04.005"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1089\/ARS.2007.1908"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1993.64.11.1098"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.18388\/ABP.2018_2749"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.CYTO.2012.06.004"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.1902\/JOP.2013.120746"},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.3390\/MOLECULES26226860"},{"key":"e_1_2_13_26_1","doi-asserted-by":"publisher","DOI":"10.1142\/S0192415X23500313"},{"key":"e_1_2_13_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.BCP.2014.09.002"},{"key":"e_1_2_13_28_1","doi-asserted-by":"publisher","DOI":"10.31083\/J.FBL2809198"},{"key":"e_1_2_13_29_1","doi-asserted-by":"publisher","DOI":"10.3892\/MMR.2017.7960"},{"key":"e_1_2_13_30_1","doi-asserted-by":"publisher","DOI":"10.3390\/IJMS20082047"},{"key":"e_1_2_13_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/J.1600\u20100714.1995.TB01141.X"},{"key":"e_1_2_13_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/J.1600\u2010051X.1994.TB00318.X"},{"key":"e_1_2_13_33_1","doi-asserted-by":"publisher","DOI":"10.1902\/JOP.1991.62.1.30"},{"issue":"2","key":"e_1_2_13_34_1","first-page":"218","article-title":"Phenytoin Sensitivity of Fibroblasts as the Basis for Susceptibility to Gingival Enlargement","volume":"112","author":"Hassell T. M.","year":"1983","journal-title":"American Journal of Pathology"},{"key":"e_1_2_13_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021\u20109258(17)35666\u20101"},{"key":"e_1_2_13_36_1","doi-asserted-by":"publisher","DOI":"10.1186\/S12967\u2010024\u201005228\u20101"},{"key":"e_1_2_13_37_1","doi-asserted-by":"publisher","DOI":"10.1186\/S12872\u2010015\u20100169\u2010Z"},{"key":"e_1_2_13_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/PTR.7499"},{"key":"e_1_2_13_39_1","doi-asserted-by":"publisher","DOI":"10.1007\/S10142\u2010023\u201001173\u20102\/TABLES\/1"},{"key":"e_1_2_13_40_1","doi-asserted-by":"publisher","DOI":"10.1097\/00002281\u2010200211000\u201000009"},{"key":"e_1_2_13_41_1","doi-asserted-by":"publisher","DOI":"10.1186\/1755\u20101536\u20105\u2010S1\u2010S24"},{"key":"e_1_2_13_42_1","doi-asserted-by":"publisher","DOI":"10.1111\/DTH.14357"},{"key":"e_1_2_13_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/ODI.13724"},{"key":"e_1_2_13_44_1","doi-asserted-by":"publisher","DOI":"10.1111\/JCMM.16178"},{"key":"e_1_2_13_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.JSPS.2022.07.006"},{"key":"e_1_2_13_46_1","doi-asserted-by":"publisher","DOI":"10.1080\/07853890.2025.2458201"},{"key":"e_1_2_13_47_1","doi-asserted-by":"publisher","DOI":"10.1248\/BPB.B24\u201000534"},{"key":"e_1_2_13_48_1","doi-asserted-by":"publisher","DOI":"10.1902\/JOP.2012.120554"},{"key":"e_1_2_13_49_1","doi-asserted-by":"publisher","DOI":"10.1902\/JOP.2016.160031"},{"key":"e_1_2_13_50_1","doi-asserted-by":"publisher","DOI":"10.1111\/J.1478\u20103231.2008.01749.X"},{"key":"e_1_2_13_51_1","doi-asserted-by":"publisher","DOI":"10.1002\/CBIN.11695"}],"container-title":["Journal of Periodontal Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jre.70112","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jre.70112","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jre.70112","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T13:59:09Z","timestamp":1786629549000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jre.70112"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,11]]},"references-count":50,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["10.1111\/jre.70112"],"URL":"https:\/\/doi.org\/10.1111\/jre.70112","archive":["Portico"],"relation":{},"ISSN":["0022-3484","1600-0765"],"issn-type":[{"value":"0022-3484","type":"print"},{"value":"1600-0765","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,11]]},"assertion":[{"value":"2025-11-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-20","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-11","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}