{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T07:11:15Z","timestamp":1779347475550,"version":"3.51.4"},"reference-count":27,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T00:00:00Z","timestamp":1779235200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T00:00:00Z","timestamp":1779235200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Periodontal Research"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To determine whether myeloid\u2010specific deletion of A20 (TNFAIP3), a key negative regulator of NF\u2010\u03baB signaling, affects periodontal supporting tissues and temporomandibular joint integrity under baseline conditions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A20\n                      <jats:sup>\n                        <jats:italic>myel\u2010KO<\/jats:italic>\n                      <\/jats:sup>\n                      and wild\u2010type littermates were analyzed at 10\u201311\u2009weeks of age using high\u2010resolution micro\u2013computed tomography and histology. Alveolar bone architecture, periodontal ligament space, epithelial morphology, and temporomandibular joint (TMJ) compartments were evaluated through quantitative micro\u2010CT measurements and qualitative histological assessment.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A20\n                      <jats:sup>myel\u2010KO<\/jats:sup>\n                      mice exhibited a craniofacial structural phenotype characterized by reduced alveolar bone volume fraction, widening of the periodontal ligament space, and altered dentoalveolar morphology. Histological analysis revealed epithelial architectural changes. In the TMJ, micro\u2010CT demonstrated reduced bone volume fraction, accompanied by histological evidence of trabecular bone loss and altered condylar growth plate organization.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>A20\u2010mediated regulation in myeloid cells contributes to the maintenance of periodontal and craniofacial skeletal homeostasis. Loss of this regulatory pathway was associated with structural alterations involving alveolar bone loss, periodontal ligament architecture, and temporomandibular joint morphology, suggesting that dysregulated myeloid inflammatory signaling may influence multiple craniofacial skeletal compartments even in the absence of experimentally induced inflammation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jre.70119","type":"journal-article","created":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T06:48:17Z","timestamp":1779346097000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Myeloid\n                    <scp>A20<\/scp>\n                    Regulates Periodontal Tissue Integrity and Temporomandibular Joint Structure"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4565-5222","authenticated-orcid":false,"given":"Karol Al\u00ed","family":"Apaza Alccayhuaman","sequence":"first","affiliation":[{"name":"Department of Oral Biology, University Clinic of Dentistry Medical University of Vienna  Vienna Austria"},{"name":"Core Facility Hard Tissue and Biomaterial Research, Karl Donath Laboratory, University Clinic of Dentistry Medical University of Vienna  Vienna Austria"},{"name":"Biomaterials and Technology, Department of Research University Center for Dental Medicine Basel UZB, University of Basel  Basel Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick","family":"Heimel","sequence":"additional","affiliation":[{"name":"Core Facility Hard Tissue and Biomaterial Research, Karl Donath Laboratory, University Clinic of Dentistry Medical University of Vienna  Vienna Austria"},{"name":"Ludwig Boltzmann Institute for Experimental and Clinical Traumatology in the AUVA Trauma Research Center Austrian BioImaging\/CMI  Vienna Austria"},{"name":"Austrian Cluster for Tissue Regeneration  Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toni","family":"Dobsak","sequence":"additional","affiliation":[{"name":"Core Facility Hard Tissue and Biomaterial Research, Karl Donath Laboratory, University Clinic of Dentistry Medical University of Vienna  Vienna Austria"},{"name":"Austrian Cluster for Tissue Regeneration  Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan","family":"Tangl","sequence":"additional","affiliation":[{"name":"Core Facility Hard Tissue and Biomaterial Research, Karl Donath Laboratory, University Clinic of Dentistry Medical University of Vienna  Vienna Austria"},{"name":"Austrian Cluster for Tissue Regeneration  Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Geert van","family":"Loo","sequence":"additional","affiliation":[{"name":"VIB Inflammation Research Center Ghent University  Gent Belgium"},{"name":"Department of Biomedical Molecular Biology Ghent University  Gent Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dieter D.","family":"Bosshardt","sequence":"additional","affiliation":[{"name":"Department of Periodontology, School of Dental Medicine University of Bern  Bern Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5400-9009","authenticated-orcid":false,"given":"Reinhard","family":"Gruber","sequence":"additional","affiliation":[{"name":"Department of Oral Biology, University Clinic of Dentistry Medical University of Vienna  Vienna Austria"},{"name":"Austrian Cluster for Tissue Regeneration  Vienna Austria"},{"name":"Department of Periodontology, School of Dental Medicine University of Bern  Bern Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,5,20]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1111\/j.1600-0757.2005.00141.x","article-title":"Structure of Periodontal Tissues in Health and Disease","volume":"40","author":"Nanci A.","year":"2006","journal-title":"Periodontology 2000"},{"issue":"1","key":"e_1_2_9_3_1","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1177\/154405910508400102","article-title":"The Junctional Epithelium: From\u00a0Health to Disease","volume":"84","author":"Bosshardt D. 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