{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T22:28:31Z","timestamp":1790548111021,"version":"4.1.0"},"reference-count":92,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T00:00:00Z","timestamp":1778716800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T00:00:00Z","timestamp":1778716800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Periodontal Research"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>Tooth loss and edentulism are common consequences of oral diseases and may compromise quality of life, yet population\u2010level evidence remains heterogeneous. This systematic review and meta\u2010analysis evaluated the association between tooth loss, edentulism, and quality of life outcomes in adults using population\u2010based epidemiological studies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>MEDLINE, Embase, Scopus, and CENTRAL were searched for observational studies of representative adult populations assessing associations between tooth loss or edentulism and oral health\u2013related quality of life (OHRQoL) or general quality of life (QoL), measured using validated instruments. Risk of bias was assessed using the Newcastle\u2013Ottawa Scale (including adaptations for cross\u2010sectional studies), and certainty of evidence was evaluated using GRADE. Random\u2010effects meta\u2010analyses were conducted for comparable adjusted effect estimates, stratified by estimand and exposure definition. For binary OHRQoL outcomes, pooling was based on study\u2010specific dichotomizations reported by the original studies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Fifty articles comprising 55 population\u2010based cohorts (287\u2009750 participants from 37 countries) were included. Among these, four were prospective cohort studies, and the remaining had cross\u2010sectional designs. Thirteen articles contributed to the quantitative synthesis. Individuals with nonfunctional dentition had approximately twice the odds of impaired OHRQoL compared with those with functional dentition [pooled adjusted odds ratio (OR)\u2009=\u20092.08; 95% CI 1.72\u20132.52;\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u200970.6%]. This association remained robust in analyses restricted to studies using the OHIP\u201014 instrument (OR\u2009=\u20092.03; 95% CI 1.65\u20132.50;\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u200965.9%). Overall associations between edentulism and impaired OHRQoL were heterogeneous; however, when restricted to OHIP\u201014\u2013based studies, edentulism was associated with impaired OHRQoL (OR\u2009=\u20093.99; 95% CI 2.62\u20136.10;\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u20090.0%). Reduced posterior occlusal support was also associated with worse OHRQoL, although the supporting evidence remains limited. Certainty of evidence for OHRQoL outcomes was rated as moderate.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In population\u2010based adult samples, tooth loss, particularly when resulting in nonfunctional dentition or reduced occlusal support, is consistently associated with poorer OHRQoL. Associations with general QoL are less consistent, reflecting broader determinants and instrument sensitivity. Preserving functional dentition and access to effective prosthetic rehabilitation may yield meaningful quality\u2010of\u2010life benefits at the population level.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jre.70121","type":"journal-article","created":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T09:10:32Z","timestamp":1778749832000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Tooth Loss and Edentulism Are Associated With Poorer Quality of Life: A Systematic Review and Meta\u2010Analyses"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8053-4517","authenticated-orcid":false,"given":"Fabio R. M.","family":"Leite","sequence":"first","affiliation":[{"name":"School of Dentistry University of Utah  Salt Lake City Utah USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3042-3103","authenticated-orcid":false,"given":"John Rong Hao","family":"Tay","sequence":"additional","affiliation":[{"name":"Health Services Research and Population Health Programme Duke\u2010NUS Medical School  Singapore Singapore"},{"name":"Department of Restorative Dentistry National Dental Centre Singapore  Singapore Singapore"},{"name":"National Dental Research Institute Singapore National Dental Centre Singapore  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-1664-9979","authenticated-orcid":false,"given":"Dian Yi","family":"Chow","sequence":"additional","affiliation":[{"name":"Department of Restorative Dentistry National Dental Centre Singapore  Singapore Singapore"},{"name":"National Dental Research Institute Singapore National Dental Centre Singapore  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7538-7866","authenticated-orcid":false,"given":"Ethan","family":"Ng","sequence":"additional","affiliation":[{"name":"Department of Restorative Dentistry National Dental Centre Singapore  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4288-6300","authenticated-orcid":false,"given":"Gustavo G.","family":"Nascimento","sequence":"additional","affiliation":[{"name":"School of Dentistry University of Utah  Salt Lake City Utah USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8329-2808","authenticated-orcid":false,"given":"Marco A.","family":"Peres","sequence":"additional","affiliation":[{"name":"Health Services Research and Population Health Programme Duke\u2010NUS Medical School  Singapore Singapore"},{"name":"National Dental Research Institute Singapore National Dental Centre Singapore  Singapore Singapore"},{"name":"Oral Health Academic Clinical Programme Duke\u2010NUS Medical School  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,14]]},"reference":[{"issue":"10482","key":"e_1_2_11_2_1","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1016\/S0140-6736(24)02811-3","article-title":"Trends in the Global, Regional, and National Burden of Oral Conditions From 1990 to 2021: A Systematic Analysis for the Global Burden of Disease Study 2021","volume":"405","author":"Collaborators GBDOD","year":"2025","journal-title":"Lancet"},{"issue":"5","key":"e_1_2_11_3_1","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1111\/jre.13337","article-title":"Burden of Severe Periodontitis and Edentulism in 2021, With Projections up to 2050: The Global Burden of Disease 2021 Study","volume":"59","author":"Nascimento G. 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