{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T14:47:35Z","timestamp":1786632455454,"version":"build-2736575974"},"reference-count":46,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,6,28]],"date-time":"2026-06-28T00:00:00Z","timestamp":1782604800000},"content-version":"vor","delay-in-days":27,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["552087827"],"award-info":[{"award-number":["552087827"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Periodontal Research"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>Antihypertensive medications are widely prescribed for hypertension, yet evidence regarding their oral health safety remains limited. We aimed to investigate whether genetically proxied pharmacological actions of antihypertensive drug classes influence the risk of periodontitis and dental caries using a two\u2010sample drug\u2010target Mendelian randomization framework.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Genetic instruments were obtained for 12 antihypertensive drug classes using variants within or near target genes associated with systolic blood pressure (SBP) in two genome\u2010wide association study (GWAS) meta\u2010analyses: one combining data from the International Consortium of Blood Pressure and UK Biobank, and another additionally including the Million Veteran Program (MVP) and Vanderbilt University's biorepository. Summary statistics for chronic periodontitis were obtained from the MVP GWAS, and for dental caries from the Gene\u2010Lifestyle Interactions in Dental Endpoints consortium using the decayed, missing, and filled surfaces index. Causal effects were estimated using the inverse\u2010variance weighted method with Benjamini\u2013Hochberg correction for multiple testing. Colocalization analyses assessed whether drug targets and outcomes shared causal variants.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Genetically proxied diazoxide acting through the KCNJ11 locus was associated with chronic periodontitis after multiple\u2010testing correction (odds ratio [OR] per 1\u2009mmHg lower SBP: 1.06, 95% confidence interval [CI]: 1.02\u20131.09), with consistent estimates after excluding variants associated with type 2 diabetes. No other associations were observed. Colocalization analyses provided no evidence of shared causal variants.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>We found little evidence that genetically proxied on\u2010target pharmacological actions of antihypertensive drug classes were associated with periodontitis or dental caries. The diazoxide\u2013periodontitis association should be interpreted with caution, given possible residual pleiotropy at the KCNJ11 locus and the absence of colocalization.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jre.70143","type":"journal-article","created":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T05:54:52Z","timestamp":1782712492000},"page":"695-704","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Genomic Evidence on Antihypertensive Drug Targets and Oral Disease Outcomes"],"prefix":"10.1111","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-7904-8738","authenticated-orcid":false,"given":"Aiswarya","family":"Puzhakkara Chennas","sequence":"first","affiliation":[{"name":"Institute of Health Services Research in Dentistry University of M\u00fcnster  M\u00fcnster 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Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6541-3127","authenticated-orcid":false,"given":"Birte","family":"Holtfreter","sequence":"additional","affiliation":[{"name":"Department of Restorative Dentistry, Periodontology and Endodontology University Medicine Greifswald  Greifswald Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9605-2822","authenticated-orcid":false,"given":"Thomas","family":"Kocher","sequence":"additional","affiliation":[{"name":"Department of Restorative Dentistry, Periodontology and Endodontology University Medicine Greifswald  Greifswald Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9391-6602","authenticated-orcid":false,"given":"Sebastian\u2010Edgar","family":"Baumeister","sequence":"additional","affiliation":[{"name":"Institute of Health Services Research in Dentistry University of 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