{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,8]],"date-time":"2026-08-08T08:43:04Z","timestamp":1786178584776,"version":"build-2736575974"},"reference-count":41,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,8,8]],"date-time":"2026-08-08T00:00:00Z","timestamp":1786147200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,8]],"date-time":"2026-08-08T00:00:00Z","timestamp":1786147200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Periodontal Research"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>This study aimed to assess the antimicrobial performance and biocompatibility of our drug delivery platform, based on layer\u2010by\u2010layer (LbL) coating incorporating tetracycline (TC) complexed with anionic \u03b2\u2010cyclodextrin (TC\u03b2CD) and a pH\u2010responsive poly(methacrylic acid) (PMAA) film, applied to titanium (Ti) surfaces representing abutment components.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A rat subcutaneous implant\u2010related infection model was established using a polymicrobial biofilm derived from peri\u2010implantitis patient saliva. Contaminated Ti controls and coated discs were implanted and analyzed after 1 and 7\u2009days through clinical, microbiological, confocal, and histological assessments. In parallel, in\u00a0vitro experiments using fibroblast cultures were conducted to evaluate the expression of genes associated with collagen synthesis and extracellular matrix remodeling.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Coated implants exhibited minimal inflammatory response, whereas control specimens presented with purulent exudate. Microbiological analysis demonstrated sustained antimicrobial activity, with &gt;\u20093 log\n                      <jats:sub>10<\/jats:sub>\n                      reduction in viable bacteria at both time points. Confocal microscopy confirmed strong microbicidal effects, particularly in the PMAA group. Coatings also modulated host responses, decreasing pro\u2010inflammatory cytokines and increasing anti\u2010inflammatory mediators and matrix remodeling markers. Histology revealed enhanced collagen deposition and accelerated connective tissue maturation, especially with LbL\/TC\u03b2CD\/PMAA, consistent with upregulated collagen\u2010related gene expression observed in\u00a0vitro.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The multifunctional coating provides sustained antimicrobial activity alongside immunomodulatory and pro\u2010regenerative effects, supporting its potential to treat implant\u2010related infections while enhancing peri\u2010implant soft tissue remodeling.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jre.70156","type":"journal-article","created":{"date-parts":[[2026,8,8]],"date-time":"2026-08-08T08:20:08Z","timestamp":1786177208000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Smart Coatings Integrating Antimicrobial and Tissue\u2010Remodeling Functions for Implant Interfaces"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-2364-9839","authenticated-orcid":false,"given":"Mariana Martins","family":"Guerreiro","sequence":"first","affiliation":[{"name":"Department of Dental Materials and Prosthodontics, School of Dentistry at Ara\u00e7atuba S\u00e3o Paulo State University (UNESP)  Ara\u00e7atuba S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3356-414X","authenticated-orcid":false,"given":"Amanda Paino","family":"Santana","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Surgery, School of Dentistry at Ara\u00e7atuba S\u00e3o Paulo State University (UNESP)  Ara\u00e7atuba S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-8651-1312","authenticated-orcid":false,"given":"Daniela Moreira","family":"Cunha","sequence":"additional","affiliation":[{"name":"Department of Dental Materials and Prosthodontics, School of Dentistry at Ara\u00e7atuba S\u00e3o Paulo State University (UNESP)  Ara\u00e7atuba S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4489-6868","authenticated-orcid":false,"given":"Gabriel","family":"Mulinari\u2010Santos","sequence":"additional","affiliation":[{"name":"Department of Basic Sciences, School of Dentistry at Ara\u00e7atuba S\u00e3o Paulo State University (UNESP)  Ara\u00e7atuba S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7916-1557","authenticated-orcid":false,"given":"Marlise In\u00eaz","family":"Klein","sequence":"additional","affiliation":[{"name":"Department of Oral Diagnosis, Piracicaba Dental School State University of Campinas (UNICAMP)  Piracicaba S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4859-0583","authenticated-orcid":false,"given":"Edilson","family":"Ervolino","sequence":"additional","affiliation":[{"name":"Department of Basic Sciences, School of Dentistry at Ara\u00e7atuba S\u00e3o Paulo State University (UNESP)  Ara\u00e7atuba S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4673-3176","authenticated-orcid":false,"given":"Ludovica","family":"Parisi","sequence":"additional","affiliation":[{"name":"Laboratory for Oral Molecular Biology, Department of Orthodontics and Dentofacial Orthopedics University of Bern  Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4356-3714","authenticated-orcid":false,"given":"Martin","family":"Degen","sequence":"additional","affiliation":[{"name":"Laboratory for Oral Molecular Biology, Department of Orthodontics and Dentofacial Orthopedics University of Bern  Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-2798-9984","authenticated-orcid":false,"given":"Maria Eduarda Fiorentino Ferreira","family":"de Andrade","sequence":"additional","affiliation":[{"name":"Department of Dental Materials and Prosthodontics, School of Dentistry at Ara\u00e7atuba S\u00e3o Paulo State University (UNESP)  Ara\u00e7atuba S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6365-8852","authenticated-orcid":false,"given":"Marta Maria Alves","family":"Pereira","sequence":"additional","affiliation":[{"name":"Department of Dental Materials and Prosthodontics, School of Dentistry at Araraquara S\u00e3o Paulo State University (UNESP)  Araraquara S\u00e3o Paulo Brazil"},{"name":"Graduate Program in Dentistry, Federal University of Piau\u00ed  Teresina Piau\u00ed Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefany Barbosa Alves","family":"da Cruz","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Surgery, School of Dentistry at Ara\u00e7atuba S\u00e3o Paulo State University (UNESP)  Ara\u00e7atuba S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2249-3048","authenticated-orcid":false,"given":"Leonardo P.","family":"Faverani","sequence":"additional","affiliation":[{"name":"Division of Oral and Maxillofacial Surgery, Department of Oral Diagnosis, Piracicaba Dental School State University of Campinas (UNICAMP)  Piracicaba S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0078-1172","authenticated-orcid":false,"given":"Paula Aboud","family":"Barbugli","sequence":"additional","affiliation":[{"name":"Department of Dental Materials and Prosthodontics, School of Dentistry at Araraquara S\u00e3o Paulo State University (UNESP)  Araraquara S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5837-0851","authenticated-orcid":false,"given":"Rodolfo Debone","family":"Piazza","sequence":"additional","affiliation":[{"name":"Department of Physical Chemistry, Institute of Chemistry S\u00e3o Paulo State University (UNESP)  Araraquara S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4739-2075","authenticated-orcid":false,"given":"Vit\u00f3ria Marega","family":"Marchetti","sequence":"additional","affiliation":[{"name":"Department of Dental Materials and Prosthodontics, School of Dentistry at Ara\u00e7atuba S\u00e3o Paulo State University (UNESP)  Ara\u00e7atuba S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodrigo Isaias 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