{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T14:04:02Z","timestamp":1790172242486,"version":"4.1.0"},"reference-count":49,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T00:00:00Z","timestamp":1790121600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T00:00:00Z","timestamp":1790121600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Periodontal Research"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To examine whether periodontitis and its ultimate sequela (edentulism) are associated with accelerated epigenetic aging in older adults.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 1 926 adults aged \u2265\u200950\u2009years with DNA\u2010methylation (DNAm) and oral health data from the NHANES 1999\u20132002\u2009cycles were included. Periodontitis (stages\/grades) and edentulism were classified using the 2018 AAP\/EFP framework via the ACES system. Epigenetic age acceleration was estimated using genome\u2010wide DNAm for four clocks: HannumAge, HorvathAge, PhenoAge, and GrimAge2Mort. Survey\u2010weighted linear regression models, adjusted for relevant confounders, assessed the relationship between periodontal status and epigenetic age acceleration.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In fully adjusted models, Stage III\u2013IV periodontitis was associated with higher biological age acceleration compared with healthy\/gingivitis\/Stage I for three of the four clocks examined: PhenoAge +2.12\u2009years (95% CI 0.64\u20133.59), HannumAge +1.48\u2009years (0.34\u20132.62), and GrimAge2Mort +1.35\u2009years (0.52\u20132.63). Associations with edentulism were stronger in 3 of the clocks: HorvathAge +1.31\u2009years (0.00\u20132.62), HannumAge +1.92\u2009years (0.72\u20133.12), and GrimAge2Mort +1.77\u2009years (0.90\u20132.65). Accelerated aging was also observed in individuals with Grade B\/C periodontitis for HorvathAge (+1.04\u2009years; 0.35\u20131.72), HannumAge (+0.93\u2009years; 0.26\u20131.60), and GrimAge (+0.55\u2009years; 0.03\u2009=\u20091.07), when compared with health\/gingivitis\/Grade A. Associations were also observed between mean interproximal CAL and age acceleration in all four clocks.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Severe and higher\u2010grade periodontitis, as well as edentulism, are associated with higher epigenetic aging acceleration, suggesting that these oral conditions may reflect\u2014or potentially contribute to\u2014systemic biological aging.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jre.70163","type":"journal-article","created":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T13:20:16Z","timestamp":1790169616000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Periodontitis, Edentulism, and Accelerated Biological Aging: A Population\u2010Based Study of Epigenetic Clocks"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-6092-6021","authenticated-orcid":false,"given":"Yi\u2010Ning","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Public Health &amp; Community Medicine Tufts University School of Medicine  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Public Health &amp; Community Medicine Tufts University School of Medicine  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5646-083X","authenticated-orcid":false,"given":"Mario","family":"Romandini","sequence":"additional","affiliation":[{"name":"Shanghai Ninth People Hospital, Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8107-3011","authenticated-orcid":false,"given":"Dominique S.","family":"Michaud","sequence":"additional","affiliation":[{"name":"Department of Public Health &amp; Community Medicine Tufts University School of Medicine  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,23]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/jre.13337"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/jre.70003"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/jre.70046"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/jre.13424"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12732"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/jre.70104"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/jre.70096"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/jre.70099"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/00220345211037977"},{"issue":"11","key":"e_1_2_11_11_1","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1007\/s11912-020-00977-w","article-title":"Biological and Functional Biomarkers of Aging: Definition, Characteristics, and How They Can Impact Everyday Cancer Treatment","volume":"22","author":"Colloca G.","year":"2020","journal-title":"Current Oncology Reports"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.5051\/jpis.2303560178"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/jre.13345"},{"issue":"1","key":"e_1_2_11_14_1","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1186\/s13148-024-01732-9","article-title":"Biological Aging Mediates the Association Between Periodontitis and Cardiovascular Disease: Results From a National Population Study and Mendelian Randomization Analysis","volume":"16","author":"Zhang Z.","year":"2024","journal-title":"Clinical Epigenetics"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.14040"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034519861037"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12337"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/JPER.20\u20100269"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12920\u2010026\u201002323\u20108"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471\u20102164\u201015\u20101174"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1186\/gb\u20102013\u201014\u201010\u2010r115"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2012.10.016"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.18632\/aging.101414"},{"issue":"2","key":"e_1_2_11_24_1","doi-asserted-by":"crossref","first-page":"303","DOI":"10.18632\/aging.101684","article-title":"DNA Methylation GrimAge Strongly Predicts Lifespan and Healthspan","volume":"11","author":"Lu A. 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