{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T08:29:41Z","timestamp":1786696181132,"version":"build-2736575974"},"reference-count":99,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T00:00:00Z","timestamp":1786665600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T00:00:00Z","timestamp":1786665600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Periodontal Research"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Fusobacterium<\/jats:italic>\n                    is a genus of anaerobic Gram\u2010negative bacteria that has been increasingly implicated in a range of diseases, including periodontitis and cancer. This review critically evaluates the reported role of\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Fusobacterium nucleatum<\/jats:italic>\n                    <\/jats:styled-content>\n                    in cancer, highlighting new findings that suggest a more nuanced cross\u2010talk with the disease. We contextualise current evidence on the interactions with the wider tumour micro\u2010environment, including the roles of polymicrobial communities, microbial metabolites and taxonomic heterogeneity. Collectively, the evidence suggests that\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Fusobacterium nucleatum<\/jats:italic>\n                    <\/jats:styled-content>\n                    should not be regarded as universally pathogenic or oncogenic. Rather, its behaviour is likely context\u2010dependent and shaped by its surrounding microenvironment. Notably, opposing pro\u2010 and anti\u2010tumoural mechanisms can coexist within the same cancer type. For example, in colorectal cancer,\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>F. nucleatum<\/jats:italic>\n                    <\/jats:styled-content>\n                    is predominantly associated with poorer outcomes by promoting immune evasion (e.g., suppression of cytotoxic T cell responses) and oncogenic signalling (e.g., via the E\u2010cadherin\/\u03b2\u2010catenin pathway), yet it also displays oncosuppressive activity through promotion of neutrophil\u2010mediated anti\u2010tumoural cytotoxicity and butyrate\u2010driven cytotoxic T cell activation and potentiation of immunotherapy. In head and neck cancer, by contrast,\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>F. nucleatum<\/jats:italic>\n                    <\/jats:styled-content>\n                    detection is associated with improved survival across independent cohorts, potentially reflecting a different balance of these same competing mechanisms. We suggest implications for its proposed use as a biomarker and as a target in cancer therapy. Lingering questions are also laid out to help investigators shape future research to better capture the complexity of the TME and elucidate the overall impact of\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Fusobacterium nucleatum<\/jats:italic>\n                    <\/jats:styled-content>\n                    in cancer.\n                  <\/jats:p>","DOI":"10.1111\/jre.70165","type":"journal-article","created":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T08:01:10Z","timestamp":1786694470000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Dual Face of\n                    <scp>\n                      <i>Fusobacterium nucleatum<\/i>\n                    <\/scp>\n                    in Cancer: Foe, Friend or Both?"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-4906-0088","authenticated-orcid":false,"given":"Anjali","family":"Chander","sequence":"first","affiliation":[{"name":"King's College London  London UK"},{"name":"Guy\u2019s and St Thomas\u2019 NHS Foundation Trust  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-3636-1519","authenticated-orcid":false,"given":"Huile","family":"Lim","sequence":"additional","affiliation":[{"name":"King's College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1350-2280","authenticated-orcid":false,"given":"Gilad","family":"Bachrach","sequence":"additional","affiliation":[{"name":"The Hebrew University\u2010Hadassah School of Dental Medicine  Jerusalem Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8288-5815","authenticated-orcid":false,"given":"Miguel Reis","family":"Ferreira","sequence":"additional","affiliation":[{"name":"King's College London  London UK"},{"name":"Guy\u2019s and St Thomas\u2019 NHS Foundation Trust  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,14]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010019\u20101238\u20108"},{"key":"e_1_2_13_3_1","doi-asserted-by":"crossref","first-page":"3247","DOI":"10.1128\/jb.175.11.3247-3252.1993","article-title":"Adhere Today, Here Tomorrow: Oral Bacterial Adherence","volume":"175","author":"Kolenbrander P. 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