{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T13:01:03Z","timestamp":1791378063071,"version":"4.3.2"},"reference-count":9,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:00:00Z","timestamp":1791331200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:00:00Z","timestamp":1791331200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Periodontal Research"],"DOI":"10.1111\/jre.70179","type":"journal-article","created":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T12:09:36Z","timestamp":1791374976000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Periodontitis\n                    <scp>GWAS<\/scp>\n                    Reveal Immune\u2010Biased Heritability Without Gingival Cell\u2010Type Resolution"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2349-6427","authenticated-orcid":false,"given":"Chengze","family":"Wang","sequence":"first","affiliation":[{"name":"Stomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Clinical Research Center for Oral Diseases of Zhejiang Province, Key Laboratory of Oral Biomedical Research of Zhejiang Province Cancer Center of Zhejiang University  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenyue","family":"An","sequence":"additional","affiliation":[{"name":"Stomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Clinical Research Center for Oral Diseases of Zhejiang Province, Key Laboratory of Oral Biomedical Research of Zhejiang Province Cancer Center of Zhejiang University  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengna","family":"Lin","sequence":"additional","affiliation":[{"name":"Stomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Clinical Research Center for Oral Diseases of Zhejiang Province, Key Laboratory of Oral Biomedical Research of Zhejiang Province Cancer Center of Zhejiang University  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Wang","sequence":"additional","affiliation":[{"name":"Stomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Clinical Research Center for Oral Diseases of Zhejiang Province, Key Laboratory of Oral Biomedical Research of Zhejiang Province Cancer Center of Zhejiang University  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1780-8757","authenticated-orcid":false,"given":"Guoli","family":"Yang","sequence":"additional","affiliation":[{"name":"Stomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Clinical Research Center for Oral Diseases of Zhejiang Province, Key Laboratory of Oral Biomedical Research of Zhejiang Province Cancer Center of Zhejiang University  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,7]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1038\/s41586-023-06592-6","article-title":"Plasma Proteomic Associations With Genetics and Health in the UK Biobank","volume":"622","author":"Sun B. B.","year":"2023","journal-title":"Nature"},{"key":"e_1_2_9_3_1","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1038\/s41586-022-05473-8","article-title":"FinnGen Provides Genetic Insights From a Well\u2010Phenotyped Isolated Population","volume":"613","author":"Kurki M. I.","year":"2023","journal-title":"Nature"},{"key":"e_1_2_9_4_1","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1111\/jcpe.70032","article-title":"Proteome\u2010Guided Drug Target Discovery for Periodontitis","volume":"53","author":"Alayash Z.","year":"2026","journal-title":"Journal of Clinical Periodontology"},{"key":"e_1_2_9_5_1","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-024-49037-y","article-title":"Single\u2010Cell and Spatially Resolved Interactomics of Tooth\u2010Associated Keratinocytes in Periodontitis","volume":"15","author":"Easter Q. T.","year":"2024","journal-title":"Nature Communications"},{"key":"e_1_2_9_6_1","doi-asserted-by":"crossref","first-page":"2773","DOI":"10.1038\/s41467-019-10630-1","article-title":"Genome\u2010Wide Analysis of Dental Caries and Periodontitis Combining Clinical and Self\u2010Reported Data","volume":"10","author":"Shungin D.","year":"2019","journal-title":"Nature Communications"},{"key":"e_1_2_9_7_1","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1038\/s41577-020-00488-6","article-title":"Local and Systemic Mechanisms Linking Periodontal Disease and Inflammatory Comorbidities","volume":"21","author":"Hajishengallis G.","year":"2021","journal-title":"Nature Reviews Immunology"},{"key":"e_1_2_9_8_1","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1111\/jcpe.13922","article-title":"A Genome\u2010Wide Association Study Meta\u2010Analysis in a European Sample of Stage III\/IV Grade C Periodontitis Patients \u226435\u2009Years of Age Identifies New Risk Loci","volume":"51","author":"Diz De Almeida S.","year":"2024","journal-title":"Journal of Clinical Periodontology"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41368\u2010026\u201000450\u20107"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010026\u201072452\u20102"}],"container-title":["Journal of Periodontal Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jre.70179","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jre.70179","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jre.70179","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T12:09:38Z","timestamp":1791374978000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jre.70179"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,7]]},"references-count":9,"alternative-id":["10.1111\/jre.70179"],"URL":"https:\/\/doi.org\/10.1111\/jre.70179","archive":["Portico"],"relation":{},"ISSN":["0022-3484","1600-0765"],"issn-type":[{"value":"0022-3484","type":"print"},{"value":"1600-0765","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,7]]},"assertion":[{"value":"2026-07-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-08","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-07","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"jre.70179"}}