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The data were drawn from the Kentucky Cancer Registry.<\/jats:p><\/jats:sec><jats:sec><jats:title>Findings<\/jats:title><jats:p>Findings from the multivariable logistic regression revealed no significant differences in the odds of ES between patients who resided in Appalachian versus non\u2010Appalachian Kentucky. Being female and undergoing surgery only as the first course of treatment were associated with higher odds of ES. Increasing age, unspecified histology, having poorly differentiated or undifferentiated carcinomas, and receiving radiation therapy only as the first course of treatment were associated with decreased odds of ES.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Differences in the odds of ES among stage IV NSCLC patients were not related to residence in Appalachian versus non\u2010Appalachian Kentucky. ES was associated with other nongenetic and treatment factors that warrant further investigations.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jrh.12537","type":"journal-article","created":{"date-parts":[[2020,11,19]],"date-time":"2020-11-19T02:54:43Z","timestamp":1605754483000},"page":"14-27","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Exceptional Survival Among Kentucky Stage IV Non\u2010small Cell Lung Cancer Patients: Appalachian Versus Non\u2010Appalachian Populations"],"prefix":"10.1111","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5762-6632","authenticated-orcid":false,"given":"Vira","family":"Pravosud","sequence":"first","affiliation":[{"name":"Department of Epidemiology, College of Public Health University of Kentucky  Lexington Kentucky"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nathan L.","family":"Vanderford","sequence":"additional","affiliation":[{"name":"Department of Toxicology and Cancer Biology, College of Medicine University of Kentucky  Lexington Kentucky"},{"name":"Markey Cancer Center, a National Cancer Institute Designated Cancer Center University of Kentucky  Lexington Kentucky"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bin","family":"Huang","sequence":"additional","affiliation":[{"name":"Division of Cancer Biostatistics, Department of Internal Medicine, College of Medicine University of Kentucky  Lexington Kentucky"},{"name":"Markey Cancer Center, a National Cancer Institute Designated Cancer Center University of Kentucky  Lexington Kentucky"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas C.","family":"Tucker","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, College of Public Health University of Kentucky  Lexington Kentucky"},{"name":"Markey Cancer Center, a National Cancer Institute Designated Cancer Center University of Kentucky  Lexington Kentucky"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susanne M.","family":"Arnold","sequence":"additional","affiliation":[{"name":"Division of Medical Oncology, Department of Internal Medicine, College of Medicine University of Kentucky  Lexington Kentucky"},{"name":"Markey Cancer Center, a National Cancer Institute Designated Cancer Center University of Kentucky  Lexington Kentucky"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,11,18]]},"reference":[{"key":"e_1_2_6_2_1","article-title":"Basic information about lung cancer","volume":"1","author":"Centers for Disease Control and Prevention","journal-title":"Lung Cancer"},{"volume-title":"SEER Cancer Statistics Review, 1975\u20132016","year":"2019","author":"Howlader N","key":"e_1_2_6_3_1"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.2147\/CLEP.S17191"},{"key":"e_1_2_6_5_1","article-title":"Annual Report to the Nation 2018: Part I. 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