{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T16:40:55Z","timestamp":1782232855800,"version":"3.54.5"},"reference-count":25,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,2,1]],"date-time":"2013-02-01T00:00:00Z","timestamp":1359676800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Small Animal Practice"],"published-print":{"date-parts":[[2013,2]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p><jats:bold>To evaluate the efficacy of hypofractionated radiotherapy for canine nasal tumours, including the improvement in clinical signs, rate of complications and assessment of prognostic factors.<\/jats:bold><\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p><jats:bold>Medical records of 38 dogs with malignant nasal tumours were reviewed, and those treated with a weekly schedule of hypofractionated radiotherapy were included in the study. Acute and late side effects were defined as complications noted either within 1\u2009month or after 6\u2009months of irradiation, respectively. Progression\u2010free interval and overall survival were calculated using the Kaplan\u2013Meier method. Log\u2010rank test and Cox proportional hazard model were also performed.<\/jats:bold><\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:bold>Clinical signs improved in 30 of 36 dogs. Acute complications were seen in 28 of 36 dogs and were considered manageable. Late complications were observed in 17 of 30 dogs that survived 6\u2009months or longer, but severe side effects were not observed. The median progression\u2010free interval and overall survival was 245\u2009days (95%<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 127\u2013512\u2009days) and 512\u2009days (95%<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 203\u2013820\u2009days), respectively. Age, breed and presence of dyspnoea were negatively correlated with overall survival.<\/jats:bold><\/jats:p><\/jats:sec><jats:sec><jats:title>Clinical Significance<\/jats:title><jats:p><jats:bold>These results suggest that hypofractionated radiotherapy could be a viable option for the treatment of nasal tumours in dogs that are not candidates for conventional multi\u2010fractionated radiotherapy.<\/jats:bold><\/jats:p><\/jats:sec>","DOI":"10.1111\/jsap.12024","type":"journal-article","created":{"date-parts":[[2013,2,1]],"date-time":"2013-02-01T18:02:58Z","timestamp":1359741778000},"page":"80-86","source":"Crossref","is-referenced-by-count":20,"title":["Efficacy of hypofractionated radiotherapy for nasal tumours in 38 dogs (2005\u20132008)"],"prefix":"10.1111","volume":"54","author":[{"given":"A.","family":"Fujiwara","sequence":"first","affiliation":[{"name":"Department of Veterinary Radiology Nippon Veterinary and Life Science University Musashino Tokyo Japan"},{"name":"Department of Veterinary Internal Medicine, the University of Tokyo Bunkyo\u2010ku Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"Japan Small Animal Cancer Center Tokorozawa Saitama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Kazato","sequence":"additional","affiliation":[{"name":"Department of Veterinary Radiology Nippon Veterinary and Life Science University Musashino Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Yayoshi","sequence":"additional","affiliation":[{"name":"Department of Veterinary Radiology Nippon Veterinary and Life Science University Musashino Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Fujita","sequence":"additional","affiliation":[{"name":"Department of Veterinary Radiology Nippon Veterinary and Life Science University Musashino Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,2]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.2005.227.936"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1740-8261.1998.tb01637.x"},{"key":"e_1_2_5_4_1","first-page":"311","article-title":"Radiotherapy of malignant nasal tumors in 67 dogs","volume":"191","author":"Adams W. 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